2015
DOI: 10.1161/atvbaha.114.304447
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Critical Role of Platelet Glycoprotein Ibα in Arterial Remodeling

Abstract: Objective— Arteriogenesis is strongly dependent on the recruitment of leukocytes, especially monocytes, into the perivascular space of growing collateral vessels. On the basis of previous findings that platelets are central players in inflammatory processes and mediate the recruitment of leukocytes, the aim of this study was to assess the role of platelets in a model of arterial remodeling. Approach and Results— C57Bl6 wild-type mice, … Show more

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Cited by 28 publications
(28 citation statements)
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“…Previous data demonstrated a proportional relationship between perfusion recovery and the arteriogenic response of the collateral vessels (Scholz et al, 2002). Moreover, LDI measurements correlate well with collateral diameter as analyzed by visual inspection as well as immunohistochemistry and vascular casting (Chandraratne et al, 2015;Heuslein et al, 2015;Teunissen et al, 2015).…”
Section: Discussionsupporting
confidence: 56%
“…Previous data demonstrated a proportional relationship between perfusion recovery and the arteriogenic response of the collateral vessels (Scholz et al, 2002). Moreover, LDI measurements correlate well with collateral diameter as analyzed by visual inspection as well as immunohistochemistry and vascular casting (Chandraratne et al, 2015;Heuslein et al, 2015;Teunissen et al, 2015).…”
Section: Discussionsupporting
confidence: 56%
“…27 These findings underline the role of GPIba in arterial remodeling and arteriogenesis. In addition, inhibition or loss of function of GPIba jeopardizes reperfusion recovery.…”
Section: Angiogenesis Arteriogenesismentioning
confidence: 81%
“…The observation that platelet count is reduced in 2B mice suggests that the presence of mutant vWF inside MKs might reduce their platelet production. An indicator of platelet production in vivo is platelet recovery following antibody-mediated depletion (18). Depletion of circulating platelets by administration of anti-mouse GPIbα antibodies resulted in a similar thrombocytopenia for both WT and 2B mice 48 hours after injection (33 ± 4 × 10 3 platelets/μl vs. 50 ± 12 × 10 3 platelets/μl, respectively).…”
Section: Resultsmentioning
confidence: 99%