Critical Role of Val/Gly86 Hla-DRB Dimorphism in the Neonatal Resistance or Susceptibility to Maternal Hepatitis C Virus Infection

Martinetti, Miryam; Pacati, Ilaria; Daielli, C.; Salvaneschi, L.; Maccabruni, Anna

doi:10.1097/00006454-199710000-00019

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…The difference in association related to sub allelic differences could to be due to glycine/valine dimorphism at position 86 of the antigen binding sites of the DR B1* molecule. HLA DRB1*86GG was associated with HCV infected children while DRB1*86VV homozygotes were seroconverts [79] . HLA-DQB1*06, -G*0105N, -Cw*0602, DRB1*1104 and -DRB1*1302 alleles are protective while HLA-Cw*07, -G*010401, -DRB1*0701, -DRB1*1401 and homozygosity for HLA-G 14bp deletion are risk factors for HCV vertical transmission in Italian children [16] .…”

Section: Hla Associations With Vertical Transmission Of Hepatitis B Amentioning

confidence: 93%

“…HLA DR13 is protective for vertical transmission in infants bor n to HCV+ ve Italian mothers [16,17] . In infants born to infected mothers HLA DRB1*1104 is associated with seroreversion and DRB1*1101 with viral persistence [79] for HCV infection. In Japanese and the DRB1*0901-DQB1*0303 haplotype is related to protection from cirrhosis in hepatitis C [70] and HLA B44-DRB1*1302-DQB1*0604 and DRB1*1302-DRB1*0604 with asymptomatic carrier phenotype [68] .…”

Section: Viral Persistence and Viral Clearancementioning

confidence: 99%

“…Liu et al [15] reported HLA DR3 carriers to be at risk of vertical transmission of HBV and DR13 carriers to be resistant in Chinese populations. In Italian subjects, HLA DR13 (DRB1*1302) and DRB1*1104 were reported to be protective in neonates for vertical transmission [16,17,79] . HLA DRB1*1104 is associated with seroreversion in infants born to infected mothers but DRB1*1101 is associated with viral persistence in such infants.…”

Section: Hla Associations With Vertical Transmission Of Hepatitis B Amentioning

confidence: 99%

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A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Singh

Kaul

et al. 2007

WJG

204

175

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Hepatitis B (HBV) and hepatitis C (HCV) viral infection or co-infection leads to risk of development of chronic infection, cirrhosis and hepatocellular carcinoma (HCC).Immigration and globalization have added to the challenges of public health concerns regarding chronic HBV and HCV infections worldwide. The aim of this study is to review existing global literature across ethnic populations on HBV and HCV related human leukocyte antigen (HLA) associations in relation to susceptibility, viral persistence and treatment. Extensive literature search was conducted to explore the HLA associations in HBV and HCV infections reported across global populations over the past decade to understand the knowledge status, weaknesses and strengths of this information in different ethnic populations. HLA DR13 is consistently associated with HBV clearance globally. HLADRB1*11/*12 alleles and DQB1*0301 are associated with HBV persistence but with HCV clearance worldwide. Consistent association of DRB1*03 and *07 is observed with HCV susceptibility and non-responsiveness to HBV vaccination across the population. HLA DR13 is protective for vertical HBV and HCV transmission in Chinese and Italian neonates, but different alleles are associated with their susceptibility in these populations. HLA class Ⅰmolecule interactions with Killer cell immunoglobulin like receptors (KIR) of natural killer (NK) cells modulate HCV infection outcome via regulating immune regulatory cells and molecules. HLA associations with HBV vaccination, interferon therapy in HBV and HCV, and with extra hepatic manifestations of viral hepatitis are also discussed. Systematic studies in compliance with global regulatory standards are required to identify the HLA specific viral epitope, stage specific T cell populations interacting with different HLA alleles during disease progression and viral clearance of chronic HBV or HCV infections among different ethnic populations. These studies would facilitate stage specific therapeutic strategies for clearance of HBV and HCV infections or co-infections across global populations and aid in identification of HBV-HCV combined vaccine. HLA associations of chronic HBV or HCV development with confounding host factors including alcohol, drug abuse, insulin resistance, age and gender are lacking and warrant detailed investigation across global populations.

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Section: Hla Associations With Vertical Transmission Of Hepatitis B Amentioning

confidence: 93%

Section: Viral Persistence and Viral Clearancementioning

confidence: 99%

Section: Hla Associations With Vertical Transmission Of Hepatitis B Amentioning

confidence: 99%

See 1 more Smart Citation

A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Singh

Kaul

et al. 2007

WJG

204

175

View full text Add to dashboard Cite

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“…The DRB1*1101 allele was also correlated with susceptibility to vertically transmitted HCV infection. 33 To examine the associations between DQB1*0301 and the DRB1*1101 alleles and self-limiting HCV more closely, a meta-analysis employing data from the published literature was conducted. 55 To ensure that similar studies were pooled, only studies examining DQB1*0301 that employed molecular genotyping techniques and compared those with self-limiting infections (HCV antibody positive, but PCR negative) to those with chronic infections (HCV antibody positive and HCV-RNA PCR positive) were employed.…”

Section: Susceptibility To Persistent Hcv Infectionmentioning

confidence: 99%

Host genetic determinants in hepatitis C virus infection

2004

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In addition to viral and environmental/behavioural factors, host genetic diversity is believed to contribute to the spectrum of clinical outcomes in hepatitis C virus (HCV) infection. This paper reviews the literature with respect to studies of host genetic determinants of HCV outcome and attempts to highlight trends and synthesise findings. With respect to the susceptibility to HCV infection, several studies have replicated associations of the HLA class II alleles DQB1*0301 and DRB1*11 with selflimiting infection predominantly in Caucasian populations. Meta-analyses yielded summary estimates of 3.0 (95% CI: 1.8-4.8) and 2.5 (95% CI: 1.7-3.7) for the effects of DQB1*0301 and DRB1*11 on self-limiting HCV, respectively. Studies of genetics and the response to interferon-based therapies have largely concerned single-nucleotide polymorphisms and have been inconsistent. Regarding studies of genetics and the progression of HCV-related disease, there is a trend with DRB1*11 alleles and less severe disease. Studies of extrahepatic manifestations of chronic HCV have shown an association between DQB1*11 and DR3 with the formation of cryoglobulins. Some important initial observations have been made with respect to genetic determinants of HCV outcome. Replication studies are needed for many of these associations, as well as biological data on the function of many of these polymorphisms.

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“…Moreover some investigators suggested the critical role of fetal immunogenetic profile in the neonatal resistance or susceptibility to maternal HCV infection. 10 HLA class II DR, DQA, and DQB typing was performed and the children's haplotype results were identical: HLA DRB1* 1101, 0401; DQA1* 0501, 0301; DQB1*0301,0302.…”

Section: Amniocentesis As a Possible Risk Factor For Mother-to-infantmentioning

confidence: 94%

Amniocentesis As A Possible Risk Factor for Mother–To–Infant Transmission of Hepatitis C Virus

et al. 2001

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Critical Role of Val/Gly86 Hla-DRB Dimorphism in the Neonatal Resistance or Susceptibility to Maternal Hepatitis C Virus Infection

Cited by 7 publications

References 4 publications

A comparative review of HLA associations with hepatitis B and C viral infections across global populations

A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Host genetic determinants in hepatitis C virus infection

Amniocentesis As A Possible Risk Factor for Mother–To–Infant Transmission of Hepatitis C Virus

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