Critical transporters of methionine and methionine hydroxy analogue supplements across the intestine: What we know so far and what can be learned to advance animal nutrition

To, Van Pham Thi Ha; Masagounder, Karthik; Loewen, Matthew E.

doi:10.1016/j.cbpa.2021.110908

Cited by 12 publications

(14 citation statements)

References 182 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Not only are the metabolism and use mechanisms different for these Met sources; they also differ in their absorption mechanisms [ 85 ]. For instance, as HMTBa is a precursor without an amino group, it is not absorbed by AA transporters, but rather by sodium-dependent and sodium-independent monocarboxylate transporters such as MCT1 [ 85 , 86 , 87 ]. As it is a racemic mixture with D- and L- enantiomers, differences in uptake mechanisms are not unexpected.…”

Section: Trace Minerals In Animal Nutritionmentioning

confidence: 99%

Relative Bioavailability of Trace Minerals in Production Animal Nutrition: A Review

Byrne

Murphy

2022

Animals

View full text Add to dashboard Cite

The importance of dietary supplementation of animal feeds with trace minerals is irrefutable, with various forms of both organic and inorganic products commercially available. With advances in research techniques, and data obtained from both in-vitro and in-vivo studies in recent years, differences between inorganic and organic trace minerals have become more apparent. Furthermore, differences between specific organic mineral types can now be identified. Adhering to PRISMA guidelines for systematic reviews, we carried out an extensive literature search on previously published studies detailing performance responses to trace minerals, in addition to their corresponding relative bioavailability values. This review covers four of the main trace minerals included in feed: copper, iron, manganese and zinc, and encompasses the different types of organic and inorganic products commercially available. Their impact from environmental, economic, and nutritional perspectives are discussed, along with the biological availability of various mineral forms in production animals. Species-specific sections cover ruminants, poultry, and swine. Extensive relative bioavailability tables cover values for all trace mineral products commercially available, including those not previously reviewed in earlier studies, thereby providing a comprehensive industry reference guide. Additionally, we examine reasons for variance in reported relative bioavailability values, with an emphasis on accounting for data misinterpretation.

show abstract

Section: Trace Minerals In Animal Nutritionmentioning

confidence: 99%

Relative Bioavailability of Trace Minerals in Production Animal Nutrition: A Review

Byrne

Murphy

2022

Animals

View full text Add to dashboard Cite

show abstract

“…As an organic acid salt rather than an amino acid, MHA exhibits lower water solubility when compared to crystalline methionine, although it cannot be utilized by animals until it is converted into L-methionine after a series of metabolic transformations. In addition, there are distinguished differences between crystalline methionine and MHA in absorption, transport and metabolism in vivo as the result of their different chemical properties ( Maenz and Engele-Schaan, 1996 ; Pham Thi Ha To et al, 2020 ; To et al, 2021 ). Recent research has shown that the transport of L-methionine relies on multiple apical sodium-dependent/independent high/low-affinity transporters, while the transport of MHA is mediated by proton-dependent monocarboxylate transporters of the SLC16 family and apical sodium monocarboxylate transporters of the SLC5 family ( To et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, there are distinguished differences between crystalline methionine and MHA in absorption, transport and metabolism in vivo as the result of their different chemical properties ( Maenz and Engele-Schaan, 1996 ; Pham Thi Ha To et al, 2020 ; To et al, 2021 ). Recent research has shown that the transport of L-methionine relies on multiple apical sodium-dependent/independent high/low-affinity transporters, while the transport of MHA is mediated by proton-dependent monocarboxylate transporters of the SLC16 family and apical sodium monocarboxylate transporters of the SLC5 family ( To et al, 2021 ). The application effects of crystalline methionine and analogue products are still controversial in aquaculture.…”

Section: Introductionmentioning

confidence: 99%

Comparative study on the effects of crystalline L-methionine and methionine hydroxy analogue calcium supplementations in the diet of juvenile Pacific white shrimp (Litopenaeus vannamei)

et al. 2023

View full text Add to dashboard Cite

An 8-week feeding trial was conducted to evaluate the effects of L-methionine and methionine hydroxy analogue calcium (MHA-Ca) supplements in low-fishmeal diet on growth performance, hepatopancreas morphology, protein metabolism, anti-oxidative capacity, and immunity of Pacific white shrimp (Litopenaeus vannamei). Four isonitrogenous and isoenergetic diets were designed: PC (203.3 g/kg fishmeal), NC (100 g/kg fishmeal), MET (100 g/kg fishmeal +3 g/kg L-methionine) and MHA-Ca (100 g/kg fishmeal +3 g/kg MHA-Ca). White shrimp (initial body weight 0.23 ± 0.00 g, 50 shrimp per tank) were allocated to 12 tanks and divided among 4 treatments in triplicates. In response to L-methionine and MHA-Ca supplementations, the shrimp exhibited higher weight gain rate (WGR), specific growth rate (SGR), condition factor (CF), and lower hepatosomatic index (HSI) compared to those fed the NC diet (p < 0.05). The WGR and SGR of shrimp fed L-methionine and MHA-Ca showed no difference with those in the PC diet (p > 0.05). Both of L-methionine and MHA-Ca supplementary diets significantly decreased the malondialdehyde (MDA) levels of shrimp when compared with the NC diet (p < 0.05). L-methionine supplementation improved the lysozyme (LZM) activity and total antioxidant capacity (T-AOC) of shrimp, while the MHA-Ca addition elevated the reduced glutathione (GSH) levels in comparison with those fed the NC diet (p < 0.05). Hypertrophied blister cells in hepatocytes were observed in shrimp fed the NC diet, and alleviated with L-methionine and MHA-Ca supplementations. Shrimp fed the MET and MHA-Ca diets had higher mRNA expression levels of target of rapamycin (tor) than those fed the NC diet (p < 0.05). Compared to the NC group, dietary MHA-Ca supplementation upregulated the expression level of cysteine dioxygenase (cdo) (p < 0.05), while L-methionine supplementation had no significant impact (p > 0.05). The expression levels of superoxide dismutase (sod) and glutathione peroxidase (gpx) were significantly upregulated by L-methionine supplemented diet in comparison with those in the NC group (p < 0.05). Overall, the addition of both L-methionine and MHA-Ca elevated the growth performance, facilitated protein synthesis, and ameliorated hepatopancreatic damage induced by plant-protein enriched diet in L. vannamei. L-methionine and MHA-Ca supplements enhanced anti-oxidants differently.

show abstract

“…Both MHA and MPA are monoacids with low pK a (pK a of MHA is 3.86, pK a of MPA is 4.34). 17,18 And the complexes they formed with Au dissolve completely only under alkaline conditions (Au(I)-MHA complexes dissolve from pH 9, Au(I)-MPA complexes dissolve from pH 8). When pH increased to 8 or 9, MHA and MPA have been nearly fully deprotonated.…”

mentioning

confidence: 99%

“…As shown in Fig.S10 and S11, (ESI †) the fluorescence intensities of Au(I)-MHA@PDDA and Au(I)-MPA@PDDA decreased with the increase of the pH value. Both MHA and MPA are monoacids with low pK a (pK a of MHA is 3.86, pK a of MPA is 4.34)17,18 and the complexes they form with Au dissolve completely only under alkaline conditions (Au(I)-MHA and Au(I)-MPA complexes respectively dissolve from pH 9 and 8). When pH increases to 8 or 9, MHA and MPA are nearly fully deprotonated.…”

mentioning

confidence: 99%

Cation polymer-induced aggregation of water-soluble Au(i)–thiolate complexes and their photoluminescence properties

Hao

Cao

et al. 2022

Chem. Commun.

View full text Add to dashboard Cite

show abstract

Critical transporters of methionine and methionine hydroxy analogue supplements across the intestine: What we know so far and what can be learned to advance animal nutrition

Cited by 12 publications

References 182 publications

Relative Bioavailability of Trace Minerals in Production Animal Nutrition: A Review

Relative Bioavailability of Trace Minerals in Production Animal Nutrition: A Review

Comparative study on the effects of crystalline L-methionine and methionine hydroxy analogue calcium supplementations in the diet of juvenile Pacific white shrimp (Litopenaeus vannamei)

Cation polymer-induced aggregation of water-soluble Au(i)–thiolate complexes and their photoluminescence properties

Contact Info

Product

Resources

About