The World Health Organization has revealed that Thailand ranks first in Asia with regard to the region’s road traffic death rate. Due to the growth in the domestic economy and demands in logistics, traffic congestion regularly occurs and brings higher risks to transportation, resulting in a constant increase in the accident rate involving heavy-duty vehicles (HDVs), with a tendency to escalate in the future. To prevent its occurrence and solve the problem, this research aims to present a “Safety HDV Model” based on four dimensions, namely, driver behaviors, unsafe roadway environment, types of vehicles and near-miss events, which are all considered as causes of accidents. In this study, the researchers use the Delphi method to obtain a consensus from experts in logistics and safety from both public and private organizations, and then they define indicators and assess the complex dimensions. Based on the consensus, the researchers find 4 dimensions, 15 factors and 55 indicators with a high level of consensus at the Kendall’s coefficient of concordance (W) of 0.402 and P less than 0.001 to be relevant to safety in logistics. To estimate the influences among dimensions, the researchers apply a structural equation model and find that both absolute fit indices and incremental fit indices demonstrate good fit, with a CMIN/DF of 1.90, RMSEA of 0.048, GFI of 0.95, AGFI of 0.92 and RMR of 0.032 for the absolute fit indices and NFI of 0.97, CFI of 0.98, TLI of 0.98 and IFI of 0.98 for the incremental fit indices. As the model is consistent with data and variables, it is considered to be valid to be adopted by responsible authorities to improve unsafe roadway environments and behaviors of HDV drivers. As the data in the model can be altered by location, the model can be utilized as a tool in strategic planning and management to prevent accidents in each area of the country in the future.