Critically ill newborns with multiple organ dysfunction: assessment by NEOMOD score in a tertiary NICU

Janota, Jan; Šimák, Jan; Straňák, Z; Matthews, Tom; Clarke, T. A.; Corcoran, David

doi:10.1007/s11845-008-0115-5

Cited by 19 publications

(20 citation statements)

References 33 publications

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“…При отсутствии нарушений со стороны одной системы орга-нов присваивается 0 баллов, при умеренной дисфунк-ции -1 балл, при выраженной дисфункции -2 балла (табл. 1) [10,11].…”

Section: дизайн исследованияunclassified

The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study

Серебрякова¹,

Беляева²,

Волосников³

2017

Pediatr. farmakol.

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Предполагается, что тяжесть синдрома полиорганной недостаточности (СПОН) у детей, перенесших критиче-ские состояния в неонатальном периоде, является фактором высокого риска развития острых респираторных инфекций (ОРИ 0,8 (0,6-0,8) (р=0,003); 4-5 лет -0,6 (0,6-0,7) и 0,4 (0,4-0,5) (р=0,001); 5-6 лет -0,5 (0,3-0,5) и 0,3 (0,2-0,3) (р=0,001); 6-7 лет -0,3 (0,3-0,3) и 0,1 (0,1-0,3) (р=0,025

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Section: дизайн исследованияunclassified

The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study

Серебрякова¹,

Беляева²,

Волосников³

2017

Pediatr. farmakol.

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“…Критерии ис-хода: благоприятный исход (выжили, переведены в профильное отделение) отмечен у 85,7 % ново-рожденных (66 человек), летальный исход за-регистрирован у 14,3 % (11 новорожденных). Для динамической оценки тяжести полиорганной недостаточности использовали шкалу The Neonatal Multiple Organ Dysfunction (NEOMOD) [14] с кри-тическим порогом ≥ 9 баллов.…”

Section: м атери а лы и ме тодыunclassified

“…Более высо-кую прогностическую точку демонстрирует работа, в которой уровни лактата выше 10 ммоль/л и насы-щение кислорода в венозной крови (SvO 2 , %) меньше 50 % связаны с развитием полиорганной недостаточ-ности [18]. В исследовательских работах показано наличие корреляции лактата с оценками по шкалам тяжести состояния и исхода [1, 4,6,[11][12][13][14][15]. Таким образом, место и значимость маркера лактата как в диагностическом, так и в прогностическом аспек-тах окончательно не определено.…”

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Evaluation Of The Lactate significance In The Neonatal Intensive Care

et al. 2017

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Background. Blood lactate level is often considered as a marker of complex metabolic disorders. Reducing the lactate’s level is a good indicator of therapy adequacy. The purpose: to show the significance of the determination of lactate for predicting the course of the postoperative period in newborns. Materials and methods. 77 infants with abdominal surgical pathology were included in an observational study. Lactate level was measured on admission to the intensive care unit and three times in the first seven days of the postoperative period. Results. ROC-analysis model showed a high predictive value of the indicator at the end of the first postoperative day and on the seventh day. Favorable outсome was connected with lactate ratio below 2.5 mmmol/L on admission, lower than 2.0 mmol/l in the third and seventh days. Point elevation to 3 mmol/l was marked at the end of the first postoperative day. Conclusion. It is advisable to manage a dynamic assessment of lactatemia at the end of the first day and to the end of the third day of the postoperative period.

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“…16 It has been proven to be an accurate predictor of mortality. 17 Several authors have previously evaluated the relationship between SVC blood flow measurements and mean blood pressure in a cohort of VLBW infants with various results. [18][19][20] In this prospective study our objectives were to evaluate the relationship between serum cortisol values and markers of cardiovascular status (SVC flow and blood pressure) as well as between cortisol values and the three aforementioned illness severity scores in VLBW infants during the first 24 h.…”

Section: Introductionmentioning

confidence: 99%

Serum cortisol values, superior vena cava flow and illness severity scores in very low birth weight infants

et al. 2010

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Objective: Recent evidence suggests that high cortisol concentrations are associated with increased morbidity and mortality in very low birth weight (VLBW) infants. Neonatal illness severity and mortality risk scores are reliable in predicting morbidity and mortality. The objectives were (i) to assess the correlation between serum cortisol levels and clinical assessment of multi-organ dysfunction/illness severity scores (CRIB II, SNAPPE-II and neonatal multiple organ dysfunction score (NEOMOD)) in first 24 h in VLBW infants and (ii) to assess the relationship between surrogates of end organ blood flow and serum cortisol levels.Study Design: A prospective observational cohort study. Neonates with birth weight <1500 g were eligible for enrollment. Echocardiography evaluation of superior vena cava (SVC) flow was carried out in the first 24 h life. Cortisol levels were measured simultaneously and appropriate clinical scores were calculated.Result: A total of 54 VLBW neonates were enrolled following parental consent. Two patients were excluded because of congenital malformations. In 14 babies the cortisol value was not simultaneously obtained. The mean birth weight was 1.08 kg, mean gestational age was 27.8 weeks. There was a significant correlation between cortisol and NEOMOD score (P ¼ 0.006). There was no correlation between cortisol and CRIB II score (P ¼ 0.34), SVC flow (P ¼ 0.49) and mean arterial blood pressure respectively (P ¼ 0.35). Conclusion:There was no correlation between SVC flow and cortisol values or between cortisol and mean blood pressure values. There was a significant correlation between cortisol levels and neonatal organ dysfunction score evaluated suggesting that stressed VLBW infants do mount a cortisol response. Keywords: VLBW; neonate; cortisol; superior vena cava; blood pressure; illness severity score IntroductionThe immediate postnatal period in very low birth weight (VLBW) infants is frequently complicated by hypotension and low end-organ flow. Superior vena cava (SVC) flow has proven to be a useful marker of systemic blood flow, 1 but is not easily obtained at the bedside. Blood pressure values are readily available at the bedside and hypotension has been associated with adverse short-term and long-term outcome.2,3 A number recent studies have focused on evaluating the role of hydrocortisone therapy in hypotension and suspected adrenocortical insufficiency in the sick preterm infants during the early course of life.

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Critically ill newborns with multiple organ dysfunction: assessment by NEOMOD score in a tertiary NICU

Abstract: The NEOMOD evaluates daily the severity of the multiple organ dysfunction syndrome (MODS) and is an accurate predictor of mortality.

Cited by 19 publications

References 33 publications

The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study

The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study

Evaluation Of The Lactate significance In The Neonatal Intensive Care

Serum cortisol values, superior vena cava flow and illness severity scores in very low birth weight infants

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