Synchronicity in the Human–Space–Time Theory of Nursing undergirds the innovative process of nursing engagement expressed as interpersonal relating, technological knowing, rhythmical connecting, and transformational engaging. The philosophical and theoretical perspectives declare the evolutionary design in affirming the meaningful human caring experiences within nursing practice. Moreover, theory-based practice sustains the human science view of wholeness of persons while focusing on the inclusion of the coexistence between technology and caring in nursing. The practice of nursing approaches human caring beyond the customary, fragmented, and routinary healthcare commitment.