Critique of ‘Odontogenic myxoma presenting as a spontaneous oro‐nasal fistula’

What Is the Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor?

“…This behaves more like COdF (non-aggressive [4,13,15,19]) than CEOT (locally aggressive [2,4,[19][20][21]). COdF frequently involves the anterior-premolar region (77% of all cases and 91% of maxillary cases [4,13,[22][23][24][25]) [3,14,21,26]. This is in contrast to CEOT, which arises most often in the mandible (59% [2]-74% [27]), particularly the posterior area (82% [19,20,26]) [1].…”

“…Most COdFs reside in a peri-or interradicular location [3, 4, 13-15, 22-26, 28], and the NCLC variant has been defined as "root-associated" [1,2,[4][5][6]. Root resorption is common in COdF (29% [13,25] to 76% [4]) [15,21,23,26], but uncommon in CEOT (4% [19,27] to 13% [2]). About 70% of cases of the NCLC variant have exhibited this radiographic characteristic [4].…”

“…About 70% of cases of the NCLC variant have exhibited this radiographic characteristic [4]. The presence of a palatal perforation of maxillary lesions anterior to the first molar (25% [24] to 80% [28]) is highly suggestive of COdF [4,15,22,23,26]. This unique COdF-associated clinical sign has been recorded in more than half of cases of the NCLC variant [4,6].…”