Crocin ameliorated skin tissue inflammation in atopic dermatitis in mice

Abstract

<p class="abstract"><strong>Background:</strong> Atopic dermatitis (AD) is considered a chronic recurrent inflammatory skin disease. In addition, crocin is the major carotenoid compound found in Gardenia jasminoides. It is previously proved to produce anti-inflammatory actions. Therefore, we conducted this research to investigate the therapeutic effects of crocin on a mice model of AD.</p><p class="abstract"><strong>Methods:</strong> Mice were investigated for the number of scratches and dermatitis score. Skin was isolated and used for measurements of gene and protein expression of β-catenin, NFκB, TNF-α and IL-1β.<strong></strong></p><p class="abstract"><strong>Results:</strong> Authors found that crocin significantly reduced the number of scratches, ear thickness and dermatitis score. In addition, crocin ameliorated AD-induced elevation in the expression of β-catenin, NFκB, TNF-α and IL-1β.</p><p class="abstract"><strong>Conclusions:</strong> Crocin ameliorated DNCB-induced AD in mice via blockage of β-catenin with subsequent reduction in inflammatory pathway.</p><p class="abstract"> </p>