Crocin prevention of anemia-induced changes in structural and functional parameters of mice testes

Kalantari-Hesari, Ali; Shahrooz, Rasoul; Ahmadi, Abbas; Hasan, Mohd Shahnaz; Saboory, Ehsan

doi:10.1016/j.jab.2015.02.001

Cited by 17 publications

(13 citation statements)

References 34 publications

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“…In this study, spermatogenesis and spermatogenesis indices, including TDI, SI and RI, showed a significant decrease due to lead induced oxidative stress, compared to control group. Induction of oxidative stress causes significant decrease in TDI, RI and SI indices in seminiferous tubules of testes in mice; as seen in the current study [30,43]. In the current study, prescribing lead acetate resulted in insignificantly decreased body weight, volume and weight of rat testes, compared to control group.…”

Section: Discussionsupporting

confidence: 68%

“…Epithelium height and seminiferous tubule diameter decreased following reduced metabolic activity of germinal cells and cell number. This caused increased interstitial space and consequently tissue edema [30]. Damaged DNA or increased apoptosis in germinal cells of seminiferous tubules are thought to be one of the effect mechanisms of lead [34,39].…”

Section: Discussionmentioning

confidence: 99%

“…Weight of genital organs, especially testes, decreases in oxidative stress; therefore, weighing testes is one of the most important parameters in toxicological studies. In similar studies, it has been reported that oxidative stress induced by lead causes decreased body weight, and net and relative weight and volume of testes in rats [7,9,30,38]. However, Asadpour et al (2013) reported that lead included no effects on body and testis weight in rats [5].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, histometrical structures of testes were analyzed, including thickness of capsule, height of germinal epithelium of seminiferous tubules, number of Sertoli cells, size of Leydig cells, number of Leydig cells in a marked scale and diameter of seminiferous tubules. Spermatogenesis and spermiogenesis were studied using analysis of TDI, RI and SI indices [30]. To analyze TDI index, ratio of seminiferous tubules with four lines or more of differentiated cells from the Type A spermatogonia was calculated.…”

Section: Histomorphometrical and Histochemical Studiesmentioning

confidence: 99%

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Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Adibmoradi¹,

Malekinejad²

2015

Reprod Syst Sex Disord

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Objective: Negative effects of lead on the male reproductive system and sperm fertility parameters have been shown broadly. In recent years, use of medicinal herbs in reducing heavy metal toxicities has increased worldwide. One of these herbals, wheat sprout, contains high amount of vitamins (especially vitamin E), antioxidants and phytoestrogen compounds. This study investigated the effects of wheat sprout extract (WSE) and vitamin E on testicular oxidative stress in rats exposed to lead acetate.Methods: Thirty-five rats were divided randomly into seven groups: G1 (control group) received 1 ml/kg/day of normal saline, G2 received 20 mg/kg/day of lead acetate, G3 and G4 received 100 mg/kg/day and 200 mg/kg/day of WSE respectively, G5 and G6 received 100 mg/kg/day and 200 mg/kg/day of WSE respectively with 20 mg/kg/day of lead acetate, and G7 received 100 mg/kg/day of vitamin E with 20 mg/kg/day of lead acetate. After 35 days, rats were sacrificed and blood, sperm, liver and testicle tissue samples were collected for histomorphological and histochemical studies.Results: Results showed that count, motility and viability of sperms decreased following the administration of lead acetate (P<0.01). Histomorphological studies showed a significant decrease in tubular differentiation index (TDI), spermiogenesis index (SI), repopulation index (RI), number of Leydig and Sertoli cells, and epithelium height and diameter of seminiferous tubules in groups receiving lead acetate (P<0.05). Conclusion:Summary, results of the current study show that dose dependent WSE significantly prevents testicular toxicity and oxidative stress effects of lead acetate.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Histomorphometrical and Histochemical Studiesmentioning

confidence: 99%

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Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Adibmoradi¹,

Malekinejad²

2015

Reprod Syst Sex Disord

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show abstract

“…Decreased ET and ST diameter are a result of reduced metabolic activity of the germinal cells as well as cell numbers with the consequence that interstitial spaces widen with oedematous appearance (46). Several studies that have examined HAART effects on semen parameters and other morphometric features of the testis (9,47), have supported our overall result indicating HAART-induced distortions do occur by changes in morphology and morphometric indices of the testis.…”

Section: Discussionmentioning

confidence: 99%

Coconut Oil Extract Mitigates Testicular Injury Following Adjuvant Treatment with Antiretroviral Drugs

et al. 2016

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Increased access to highly active antiretroviral therapy (HAART) has made the management of drug toxicities an increasingly crucial component of HIV. This study investigated the effects of adjuvant use of coconut oil and HAART on testicular morphology and seminal parameters in Sprague- Dawley rats. Twelve adult male Sprague-Dawley rats, weighing 153~169 g were distributed into four groups (A–D) and treated as follows: A served as control (distilled water); B (HAART cocktail- Zidovudine, Lamivudine and Nevirapine); C (HAART + Virgin coconut oil 10 mL/kg) and D (Virgin coconut oil 10 mL/kg). After 56 days of treatment, animals were killed and laparotomy to exercise the epididymis for seminal fluid analyses done whilst testicular tissues were processed for histomorphometric studies. Result showed a significant decline in sperm motility (P < 0.05) and count (P < 0.0001) in HAART-treated animals while there was insignificant changes in other parameters in groups C and D except count that was reduced (P < 0.0001) when compared with controls. Histomorphological studies showed HAART caused disorders in seminiferous tubular architecture with significant (P < 0.01) decline in epithelial height closely mirrored by extensive reticulin framework and positive PAS cells. Adjuvant Virgin coconut oil + HAART resulted in significant decrease in seminiferous tubular diameter (P < 0.05), but other morphometric and histological parameters were similar to control or Virgin coconut oil alone (which showed normal histoarchitecture levels). While derangements in testicular and seminal fluid parameters occurred following HAART, adjuvant treatment with Virgin coconut oil restored the distortions emanating thereof.

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Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats

Yaribeygi

Atkin

Barreto

et al. 2021

Advances in Experimental Medicine and Biology

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Crocin prevention of anemia-induced changes in structural and functional parameters of mice testes

Cited by 17 publications

References 34 publications

Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Coconut Oil Extract Mitigates Testicular Injury Following Adjuvant Treatment with Antiretroviral Drugs

Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats

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