Crocin Prevents Patulin‐Induced Acute Toxicity in Cardiac Tissues via the Regulation of Oxidative Damage and Apoptosis

Boussabbeh, Manel; Salem, Intidhar Ben; Neffati, Fadoua; Najjar, Mohamed Fadhel; Bacha, Hassen; Abid‐Essefi, Salwa

doi:10.1002/jbt.21718

Cited by 30 publications

(11 citation statements)

References 39 publications

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“…Previous studies have shown that patulin induced oxidative stress 13 14 15 16 and p53 activation 17 18 19 . We first confirmed these findings in the cell line used in the present study.…”

Section: Resultsmentioning

confidence: 92%

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p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation

Huan

Yin

Song

et al. 2016

Sci Rep

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Patulin is a major mycotoxin found in fungal contaminated fruits and their derivative products. Previous studies showed that patulin was able to induce increase of reactive oxygen species (ROS) generation and oxidative stress was suggested to play a pivotal role in patulin-induced multiple toxic signaling. The objective of the present study was to investigate the functional role of p53 in patulin-induced oxidative stress. Our study demonstrated that higher levels of ROS generation and DNA damage were induced in wild-type p53 cell lines than that found in either knockdown or knockout p53 cell lines in response to patulin exposure, suggesting p53 activation contributed to patulin-induced ROS generation. Mechanistically, we revealed that the pro-oxidant role of p53 in response to patulin was attributed to its ability to suppress catalase activity through up-regulation of PIG3. Moreover, these in vitro findings were further validated in the p53 wild-type/knockout mouse model. To the best of our knowledge, this is the first report addressing the functional role of p53 in patulin-induced oxidative stress. The findings of the present study provided novel insights into understanding mechanisms behind oxidative stress in response to patulin exposure.

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“…Previous studies have shown that patulin induced oxidative stress 13 14 15 16 and p53 activation 17 18 19 . We first confirmed these findings in the cell line used in the present study.…”

Section: Resultsmentioning

confidence: 92%

“…Oxidative stress was suggested to play a pivotal role in patulin-induced multiple toxic signaling 14 15 16 . Consistent with DNA damage, p53 was activated in response to patulin exposure both in vitro and in vivo 17 18 19 . However, the functional role of p53 in the regulation of ROS generation by patulin has not been addressed.…”

mentioning

confidence: 88%

p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation

Huan

Yin

Song

et al. 2016

Sci Rep

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“…This study indicated that crocins potentiated antioxidant capacity as it increased SOD and catalase (CAT) levels, and decreased MDA level, similar to vitamin E (Dianat et al ., ). In addition, it was indicated that crocin could inhibit patulin (PAT)‐induced acute toxicity in cardiac tissues through amelioration of oxidative damage in mice (Boussabbeh et al ., ). PAT increased CPK level, induced lipoperoxydation and protein oxidation, and triggered the activities of antioxidant enzymes such as SOD and CAT.…”

Section: Methodsmentioning

confidence: 97%

“…The effect of α‐crocin on PAT‐induced toxicity in human colon carcinoma (HCT116) and embryonic kidney cells (HEK293) was also examined. It was observed that antioxidant activity of crocins decreased endoplasmic reticulum stress activation and lipid peroxidation production (Boussabbeh et al ., 2015).…”

Section: Methodsmentioning

confidence: 99%

Antiinflammatory, Antioxidant, and Immunomodulatory Effects ofCrocus sativusL. and its Main Constituents

2016

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Crocus sativus L. (C. sativus), commonly known as saffron, is used as a food additive, preservative, and medicinal herb. Traditionally, it has been used as an alternative treatment for different diseases. C. sativus' medicinal effects are related to its major constituents like crocins, crocetin, and safranal. According to the literature, C. sativus and its constituents could be considered as an effective treatment for neurodegenerative disorders, coronary artery diseases, asthma, bronchitis, colds, fever, diabetes, and so on. Recently, numerous studies have reported such medicinal properties and found that the underlying mechanisms of action may be mediated by antioxidant, inflammatory, and immunomodulatory effects. C. sativus enhances the antioxidant capacity and acts as a free radical scavenger. As an antiinflammatory and immunomodulatory agent, it modulates inflammatory mediators, humoral immunity, and cell-mediated immunity responses. This review highlights in vitro and animal findings regarding antiinflammatory, antioxidant, and immunomodulatory effects of C. sativus and its constituents. Present review found that the C. sativus and its main constituents such as safranal, crocins, and crocetin could be effective against various diseases because of their antioxidant, anti-inflammation, and immunomodulatory effects. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Patulin cardiotoxicity is sustained by a study on mice [25], which showed that patulin induced oxidative stress and cell apoptosis. These effects can also lead to alterations of cardiac functions.…”

Section: Resultsmentioning

confidence: 99%

Effects of Patulin Treatment on Zebrafish (Danio rerio) Internal Organs

Mandalian¹,

Dragomir²,

Pasca³

2020

Rev. Chim.

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Patulin is a common contaminant of many food products which are part of humans or animals daily nutrition: fruits and fruit products, cereals, diary products and sausages. In the present study, adult zebrafish were divided in 2 groups: Control and patulin-treated group which was exposed to patulin (70 �g/L) for 7 days. Histological alterations of the control and patulin-treated group were examined and compared, with emphasis on liver, kidney, pancreas, intestine, brain and myocardium. While the Control group had no histological alterations, the patulin-exposed zebrafish show severe hepatocyte alteration, medium to severe degeneration of urinary epithelium, enterocytes hyalinosis, partial coagulation necrosis of the Langerhans islets and myocardial edema.

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Crocin Prevents Patulin‐Induced Acute Toxicity in Cardiac Tissues via the Regulation of Oxidative Damage and Apoptosis

Cited by 30 publications

References 39 publications

p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation

p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation

Antiinflammatory, Antioxidant, and Immunomodulatory Effects ofCrocus sativusL. and its Main Constituents

Effects of Patulin Treatment on Zebrafish (Danio rerio) Internal Organs

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