Crocus sativus restores dopaminergic and noradrenergic damages induced by lead in Meriones shawi: A possible link with Parkinson’s disease

Tamegart, Lahcen; Abbaoui, Abdellatif; Makbal, Rachida; Zroudi, Mohamed; Bouizgarne, Brahim; Bouyatas, My Mustapha; Gamrani, Halima

doi:10.1016/j.acthis.2018.12.003

Cited by 39 publications

(9 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Saffron and its constituents crocin and crocetin were also shown to exert neuroprotective effects by inhibiting the aggregation and accumulation of a-synuclein (Inoue et al, 2018). In a study conducted by Tamegart et al, saffron reversed dopaminergic and noradrenergic damage induced by lead (Tamegart et al, 2019). As well as in animal and cell models, neuroprotective effects of saffron and crocin were also confirmed by Rao et al in a drosophila model of parkinsonism (Rao et al, 2016).…”

Section: Parkinson's Diseasementioning

confidence: 83%

Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside

2020

View full text Add to dashboard Cite

The increasing morbidity rates of brain disorders and conditions such as anxiety, depression, Alzheimer's disease, and Parkinson's disease have become a severe problem in recent years. Although researchers have spent considerable time studying these diseases and reported many positive outcomes, there still are limited drugs available for their treatment. As a common traditional Chinese medicine (TCM), saffron was employed to treat depression and some other inflammatory diseases in ancient China due to its antioxidant, anti-inflammatory, and antidepressant properties. In modern times, saffron and its constituents have been utilized, alone and in TCM formulas, to treat neuropsychiatric and neurodegenerative diseases. In this review, we mainly focus on recent clinical and preclinical trials of brain disorders in which saffron was applied, and summarize the neuroprotective properties of saffron and its constituents from chemical, pharmacokinetic, and pharmacological perspectives. We discuss the properties of saffron and its constituents, as well as their applications for treating brain disorders; we hope that this review will serve as a comprehensive reference for studies aimed at developing therapeutic drugs based on saffron.

show abstract

Section: Parkinson's Diseasementioning

confidence: 83%

Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside

2020

View full text Add to dashboard Cite

show abstract

“…According to some studies, saffron can regulate the homeostasis of metal ions and can restore tyrosine hydroxylase levels. This enzyme helps convert the protein building block tyrosine to catecholamines and, therefore, Pb‐induced dopamine and noradrenergic injuries can be restored (Tamegart et al, 2019).…”

Section: Improvement Of Cognitionmentioning

confidence: 99%

Therapeutic potential of saffron in brain disorders: From bench to bedside

Bej,

Volpe,

Cesare

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

Saffron is a spice derived from the flower of Crocus sativus L., which has been used for centuries as a coloring and flavoring agent, as well as a source of medicinal compounds. Saffron contains various bioactive constituents, such as crocin, crocetin, safranal, picrocrocin, and kaempferol, that have shown potential benefits for human health. Among them, crocin is the most abundant and characteristic constituent of saffron, responsible for its bright red color and antioxidant properties. One of the most promising applications of saffron and its constituents is in the prevention and treatment of neurological disorders, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, and other brain disorders. Saffron and its constituents have been reported to exert neuroprotective effects through various mechanisms, such as modulating neurotransmitters, enhancing neurogenesis, reducing neuroinflammation, regulating oxidative stress, activating the Nrf2 signaling pathway, and modulating epigenetic factors. Several clinical and preclinical studies have demonstrated the efficacy and safety of saffron and its constituents in improving cognitive function, mood, and other neurological outcomes. In this review, we summarize the current evidence on the therapeutic potential of saffron and its constituents in neurological disorders, from bench to bedside. We also discuss the challenges and future directions for the development of saffron‐based therapies for brain health.

show abstract

“…Experiments have demonstrated that Pb exposure may cause PD, resulting in memory and cognitive impairment, symptoms similar to dementia in AD ( 102 , 103 ). Saffron extract was able to improve Pb-induced dopamine and noradrenergic injuries by restoring tyrosine hydroxylase levels within the substantia nigra compacta, ventral tegmental area, locus coeruleus, dorsal striatum and medial forebrain bundle ( 104 , 105 ). Patients with MS usually suffer from cognitive impairment ( 106 ), with memory impairment and spatial perception disorders being the most common cognitive deficits ( 107 , 108 ).…”

Section: Improvement Of Cognition and Learning Abilitymentioning

confidence: 99%

Active constituents of saffron (Crocus sativus L.) and their prospects in treating neurodegenerative diseases (Review)

Yang¹,

Qiu²,

Wu³

et al. 2023

Exp Ther Med

View full text Add to dashboard Cite

Crocus sativus L. (saffron) is widely used as a traditional spice for flavoring, coloring and medicinal purposes. As a traditional Chinese herb, saffron promotes blood circulation, removes blood stasis, cools and detoxifies the blood, relieves depression and calms the mind. According to modern pharmacological studies, the active constituents of saffron, including crocetin, safranal and crocus aldehyde, exhibit antioxidant, anti-inflammatory, mitochondrial function-improving and antidepressant effects. Thus, saffron has the potential to treat neurodegenerative diseases (NDs) associated with oxidative stress, inflammation and impaired mitochondrial function, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and cerebral ischemia. The present article provides a review of the pharmacological effects of saffron and its constituents in terms of neuroprotective effects, including antioxidant and anti-inflammatory effects and the improvement of mitochondrial dysfunction, as well as their clinical application in treating NDs. Contents1. Introduction 2. Methods 3. Antioxidant effect of saffron and its active constituents 4. Anti-inflammatory capacity of saffron and its active constituents 5. Improvement of mitochondrial dysfunction 6. Improvement of cognition and learning ability 7. Other effects of saffron and its active constituents 8. Conclusions and prospects

show abstract

Crocus sativus restores dopaminergic and noradrenergic damages induced by lead in Meriones shawi: A possible link with Parkinson’s disease

Cited by 39 publications

References 68 publications

Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside

Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside

Therapeutic potential of saffron in brain disorders: From bench to bedside

Active constituents of saffron (Crocus sativus L.) and their prospects in treating neurodegenerative diseases (Review)

Contact Info

Product

Resources

About