1968
DOI: 10.1136/bmj.2.5603.466
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Crohn's disease and carcinoma of colon.

Abstract: [WITH SPECIAL PLATE BETWEEN PAGES 466 AND 467] Brit. med. J., 1968, 2, 466-468 In a recent survey of Crohn's disease undertaken at the Radcliffe Infirmary three cases were encountered in which both carcinoma of the colon and Crohn's disease were present. As it is generally held that there is no association between these two diseases it seems important to report these cases and to discuss the possibility that a genuine association exists. Investigations.-Haemoglobin 7.2 g./100 ml. Blood filmmarked iron-de… Show more

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Cited by 68 publications
(10 citation statements)
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“…However, Perrett, Truelove, and Massarella (1968) have reported three cases of carcinoma of the colon associated with Crohn's disease of that organ and reviewed other cases in the literature. Their cases differed from these in that the granulomatous lesion was an incidental finding on operating to remove the carcinoma, quite the reverse of the present series, and none of their patients had a prolonged history of bowel disease before diagnosis of the carcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…However, Perrett, Truelove, and Massarella (1968) have reported three cases of carcinoma of the colon associated with Crohn's disease of that organ and reviewed other cases in the literature. Their cases differed from these in that the granulomatous lesion was an incidental finding on operating to remove the carcinoma, quite the reverse of the present series, and none of their patients had a prolonged history of bowel disease before diagnosis of the carcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…The only other local complication which was confined to the new cases was carcinoma of the colon, which occurred in four patients. Three of these patients have already been reported in detail (Perrett et al, 1968). The fourth patient was a man who, in 1958, when aged 69, developed anaemia, bleeding, and a right-sided abdominal mass.…”
Section: Local Complicationsmentioning
confidence: 94%
“…Abnormal proportions of T to B lymphocytes might also explain the humoral defects in this condition. The development of malignancy in coeliac disease (32) and pos sibly in Crohn's disease (25) may be linked to the continued loss of immunologically competent lymphocytes.…”
Section: Discussionmentioning
confidence: 99%