Crohnʼs disease in a southern European country: Montreal classification and clinical activity

Magro, Fernando; Portela, Francisco; Lago, Paula; Vieira, Ana Isabel; Peixe, Paula; Cremers, Isabelle; Cotter, José; Cravo, Marília; Tavares, L.; Reis, Jorge dos; Gonçalves, Raquel; Lopes, Horácio; Caldeira, Paulo; Ministro, Paula; Carvalho, Laís de; Azevedo, Luís Filipe; Costa-Pereira, A

doi:10.1002/ibd.20901

Cited by 26 publications

(23 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, the involvement of the upper gastrointestinal (GIT) tract occurred in six patients (4.8%), 4% concurrent to other locations. This data are similar to the published by Thin et al, in that only 1% of the study population had an isolated upper GIT condition and 3.3% had concomitant involvement, L1, L2 or L3 7 . It has also been reported that the risk of recurrence is higher when the disease occurs in the terminal ileum and ileocolic regions 8.9 .…”

Section: Results Results Results Resultssupporting

confidence: 91%

Montreal classification of patient operated for Crohn's disease and identification of surgical recurrence predictors

Bechara

Filho

Ferrari

et al. 2015

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

Section: Results Results Results Resultssupporting

confidence: 91%

Montreal classification of patient operated for Crohn's disease and identification of surgical recurrence predictors

Bechara

Filho

Ferrari

et al. 2015

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

“…The MC represents, thus, an important attempt to relate clinical practice to research progress (26) . Considering baseline characteristics of CD patients enrolled in the present study, there were not significant differences about female to male ratio, or mean age of each group according to age at diagnosis, in comparison to larger studies (3,7,17) . In addition, no significant differences were identified comparing race to other variables; in this sense, a large multicentric study comparing white with black CD patients did not find differences with respect to age of onset, disease presentation and course, and rates of hospitalization and surgeries (28) ; this enables to question how important is to consider the variable race in CD.…”

Section: Discussioncontrasting

confidence: 76%

“…Such predominance can be explained by the fact of considering perianal disease in group of penetrating behavior. Studies applying MC show predominant B1 behavior (3,17) . The relatively short mean follow-up of 5.5 years in the present study, likewise, might have contributed to these findings, inasmuch as the disease behavior seems to change over time (15,16) , as will be further discussed below.…”

Section: Discussionmentioning

confidence: 99%

“…These findings are partly similar to a large Portuguese multicentric study recently published. Researchers applied MC for CD to 1692 patients; results showed that most of patients had ileocolonic manifestations (45%), followed by exclusive ileal onset (34%), and exclusive colonic involvement (15%); only 1% had upper gastrointestinal onset (17) . Considering disease behavior, the findings of the present study show that the majority of patients had nonstricturing, nonpenetrating behavior; this differs from some studies using VC, which show a predominant B3 behavior (4,6,15) .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Montreal classification for Crohn's disease: clinical application to a Brazilian single-center cohort of 90 consecutive patients

Torres

Rodrigues

Junqueira

et al. 2010

Arq. Gastroenterol.

View full text Add to dashboard Cite

CONTEXT: Crohn's disease presents very heterogeneous features from a clinical point of view, and classifying Crohn's disease patients in homogeneous subgroups in the light of genetic, molecular and clinical aspects is challenging. The Montreal Classification for Crohn's disease was proposed in 2005 as an effort to characterize Crohn's disease patients according to recent clinical and research advances in the field of inflammatory bowel disease. Since its proposition, the Montreal Classification needs an ample validation and application among different populations around the world. To date, there are no known studies applying the Montreal Classification to a Brazilian cohort of Crohn's disease patients. OBJECTIVES: To apply the Montreal Classification to a Brazilian cohort of Crohn's disease patients at a referral center for inflammatory bowel disease in Northwestern São Paulo State, Brazil. METHODS: We selected 90 consecutive well-characterized Crohn's disease patients assisted at Inflammatory Bowel Disease Outpatient Clinic between January 1992 and January 2007, with a minimum follow-up of 2 years; data concerning demographic characteristics, clinical onset of disease, age at diagnosis, time of disease, location and behavior of disease, presence of extraintestinal manifestations, familial occurrence, perianal involvement, treatment with biological drugs, and history of surgical treatment were evaluated. RESULTS: Male patients were predominant (54%), with a mean age at diagnosis of 33 ± 14 years old, and a median followup of 5.5 years. Most of the patients were diagnosed between 17 and 40 years old (59%), and had disease located in terminal ileum 46%), with a nonstricturing, nonpenetrating behavior (71%). Time of disease was correlated with necessity of biological treatment, disease behavior, and surgical treatment (P<0.05). CONCLUSIONS: These study findings are consistent with results from other studies conducted among different populations, although a further multicentric study with a larger number of patients would be necessary to validate the Montreal Classification among Brazilian population.

show abstract

“…Indeed, only 12% of patients with isolated ileal disease develop perianal fistulas, compared with 92% of patients with rectal involvement [2]. These results were recently corroborated by a large cross-sectional study carried out in our country [5].…”

Section: Introductionsupporting

confidence: 65%

CARD15 Mutations and Perianal Fistulating Crohn’s Disease: Correlation and Predictive Value of Antibiotic Response

et al. 2010

Self Cite

View full text Add to dashboard Cite

Background CARD15 mutations alter bowel immunity and increase susceptibility to Crohn 0 s disease (CD). However, the relation between these mutations and Crohn 0 s perianal fistulas has not been fully clarified. Aims To assess whether CARD15 mutations are associated with risk of developing Crohn's perianal fistulas and whether these mutations are predictors of the response of perianal fistulas to antibiotics. Methods CARD15 mutations were investigated in 203 consecutive CD patients. Presence/absence of history of perianal fistula was recorded. Patients with history of perianal fistula were divided into two groups (with/without CARD15 mutations), and response to antibiotics was evaluated in both groups. Results Of the 203 patients, 60 (29.6%) showed at least one CARD15 mutation and 55 (27.1%) had history of perianal fistula. History of perianal fistula was identified in 13 (21.7%) patients with mutations and in 42 (29.4%) patients without mutations (P = 0.260). Mean age at diagnosis of first perianal fistula was similar in patients with/without CARD15 mutations (28.7 ± 9.8 versus 29.7 ± 10.1 years, P = 0.758). Average time between disease onset and diagnosis of first perianal fistula was also similar in the two groups (4.6 ± 5.1 versus 5.0 ± 5.9 years, P = 0.816). Response of perianal fistulas to antibiotics (metronidazole alone or combined with ciprofloxacin) was significantly higher in patients without CARD15 mutations (7.7% versus 40.5%, P = 0.041). Conclusions In CD, CARD15 mutations are not associated with risk of developing perianal fistulas or with time of their outbreak. Nevertheless, patients with perianal fistulas and CARD15 mutations showed worse response to antibiotics.

show abstract

Crohnʼs disease in a southern European country: Montreal classification and clinical activity

Cited by 26 publications

References 20 publications

Montreal classification of patient operated for Crohn's disease and identification of surgical recurrence predictors

Montreal classification of patient operated for Crohn's disease and identification of surgical recurrence predictors

The Montreal classification for Crohn's disease: clinical application to a Brazilian single-center cohort of 90 consecutive patients

CARD15 Mutations and Perianal Fistulating Crohn’s Disease: Correlation and Predictive Value of Antibiotic Response

Contact Info

Product

Resources

About