1986
DOI: 10.1001/archinte.146.4.753
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Crohn's disease in the elderly. A statistical comparison with younger patients matched for sex and duration of disease

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Cited by 50 publications
(41 citation statements)
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“…[14][15][16][17][18] Patients with Crohn's disease or DD can have similar signs and symptoms, making clinical distinction between the two diseases difficult. 12,[19][20][21] One histologic pattern of Crohn's colitis has patchy inflammation with minimal or no crypt architectural distortion. A distinction between DDrelated inflammation and Crohn's disease may not be possible if only one biopsy tissue fragment is obtained.…”
Section: Discussionmentioning
confidence: 99%
“…[14][15][16][17][18] Patients with Crohn's disease or DD can have similar signs and symptoms, making clinical distinction between the two diseases difficult. 12,[19][20][21] One histologic pattern of Crohn's colitis has patchy inflammation with minimal or no crypt architectural distortion. A distinction between DDrelated inflammation and Crohn's disease may not be possible if only one biopsy tissue fragment is obtained.…”
Section: Discussionmentioning
confidence: 99%
“…Early historical studies have suggested that the phenotypic clinical expression of Crohn's disease differs substantially, depending on the age of initial diagnosis [16][17][18][19][20] . This agedependent phenotypic clinical expression probably reflects the dynamic nature of the disorder [21] .…”
Section: Age-related Phenotypic Expressionmentioning
confidence: 99%
“…In one study, the interval between onset of symptoms and the diagnosis of CD was 6.4 years in the elderly as compared with 2.4 years in younger people [11]. The prevalence of extraintestinal manifestations of CD is unaffected by the age of onset [11].…”
Section: Opinion Statementmentioning
confidence: 98%
“…Up to 25% of patients with newly diagnosed CD are elderly; most studies have noted a female predominance of almost 2:1 when the disease presents later in life as compared with the relatively equal incidence of CD in both sexes when the disease has its onset in younger subjects [2]. CD limited to the colon (Crohn's colitis) occurs more commonly in the elderly than in the young, and there is a trend towards involvement of more distal sites in the colon just as with UC [6,[10][11][12][13]. The clinical presentation of CD in the elderly generally is similar to that in younger populations, with diarrhea and abdominal pain being the most frequent symptoms [3].…”
Section: Opinion Statementmentioning
confidence: 99%
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