Crohn's disease of the mouth: an indicator of intestinal involvement.

Orofacial Granulomatosis Associated with Crohn's Disease

“…OFG may precede gastrointestinal disease by several years and may be the only obvious focus of disease 6,7 . In this regard, Scully et al 8 found that 37% of patients, having no intestinal symptoms but with clinical evidence of oral CD, had demonstrable intestinal disease. Sanderson et al 5 also found that endoscopic and histologic intestinal abnormalities were common in patients with OFG and without gastrointestinal symptoms.…”

Asymptomatic Inflammatory Bowel Disease Presenting With Mucocutaneous Findings

“…Many patients with orofacial granulomatosis do eventually develop gastrointestinal disease consistent with Crohn's disease. 20,21 "Cobblestoning" refers to nodular granulomatous swellings that result in a cobblestone appearance of the oral mucosa, particularly on the labial and buccal mucosa. Along with mucosal tags, cobblestoning is highly suggestive of Crohn's disease.…”

The differential diagnosis of cheilitis

“…A Melkersson-Rosenthal szindróma esetenként a Crohn-betegség (16,27,43,65,78), sarcoidosis (3) vagy az orofaciális granulomatózis orális manifesztációja képé-ben jelentkezhet.…”

“…Kialakulása évekkel megelôzheti az ún. inflammatory bowel disease (IBD) tünetegyüttest (27,43,65,72).…”