Crohn's disease: orofacial considerations and disease pathogenesis

Kalmar, John R.

doi:10.1111/j.1600-0757.1994.tb00030.x

Cited by 35 publications

(34 citation statements)

References 137 publications

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“…It can occur simultaneously with bowel symptoms or it may precede CD diagnosis, and therefore an appropriate work‐up is needed to exclude bowel involvement. Usually, the bowel disease develops within a few months of the orofacial condition, but delays of up to 9 years have also been reported . Orofacial CD can affect all age groups, but it has been suggested to be more common in children than adults.…”

Section: Spectrum Of Oral Manifestations In Ibdmentioning

confidence: 99%

“…Colonic, rather than small intestinal, CD is more often associated with oral manifestations . An important differential diagnosis in young patients is Adamantiadis‐Behcet's disease . Adamantiadis‐Behcet's disease patients may have GI involvement identical or similar to that of IBD and co‐existence of both diseases in the same patient has been reported…”

Section: Spectrum Of Oral Manifestations In Ibdmentioning

confidence: 99%

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Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Κατσάνος

Torres

Roda

et al. 2015

Aliment Pharmacol Ther

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Summary Background Patients with inflammatory bowel diseases (IBD) may present with lesions in their oral cavity. Lesions may be associated with the disease itself representing an extraintestinal manifestation, with nutritional deficiencies or with complications from therapy. Aim To review and describe the spectrum of oral nonmalignant manifestations in patients with inflammatory bowel diseases [ulcerative colitis (UC), Crohn's disease (CD)] and to critically review all relevant data. Methods A literature search using the terms and variants of all nonmalignant oral manifestations of inflammatory bowel diseases (UC, CD) was performed in November 2014 within Pubmed, Embase and Scopus and restricted to human studies. Results Oral lesions in IBD can be divided into three categories: (i) lesions highly specific for IBD, (ii) lesions highly suspicious of IBD and (iii) nonspecific lesions. Oral lesions are more common in CD compared to UC, and more prevalent in children. In adult CD patients, the prevalence rate of oral lesions is higher in CD patients with proximal gastrointestinal tract and/or perianal involvement, and estimated to range between 20% and 50%. Oral lesions can also occur in UC, with aphthous ulcers being the most frequent type. Oral manifestations in paediatric UC may be present in up to one‐third of patients and are usually nonspecific. Conclusions Oral manifestations in IBD can be a diagnostic challenge. Treatment generally involves managing the underlying intestinal disease. In cases presenting with local disabling symptoms and impaired quality of life, local and systemic medical therapy must be considered and/or oral surgery may be required.

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Section: Spectrum Of Oral Manifestations In Ibdmentioning

confidence: 99%

Section: Spectrum Of Oral Manifestations In Ibdmentioning

confidence: 99%

Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Κατσάνος

Torres

Roda

et al. 2015

Aliment Pharmacol Ther

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“…There is occurrence of aphthous‐like lesions, small mucosal pustules, and cobblestone‐like mucosal overgrowth. Useful evaluations for differentiation of OFG and Crohn disease include ESR, complete blood count, serum folic acid, iron, vitamin B12, and gastrointestinal evaluation, including an endoscopy and biopsy 12 . In the present case, upon medical examination there were no abdominal symptoms, and both the ESR and C‐reactive protein levels were within normal limits.…”

Section: Discussionmentioning

confidence: 52%

Gingival Manifestations of Orofacial Granulomatosis: A Rare Finding

Chandna

Mahendra

Kaur

2017

Clin Adv Periodontics

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Introduction: Orofacial granulomatosis (OFG) is a rare idiopathic, non‐necrotizing granulomatous lesion of soft tissue in the orofacial region. It is clinically characterized by persistent swelling of lips (one or both), oral ulceration, and gingival enlargement. Case Presentation: A 21‐year‐old female patient presented with diffuse persistent anterior maxillary and mandibular gingival enlargement with upper lip swelling for the last 2 years. Clinical presentation, along with a histologic examination, confirmed a diagnosis of OFG. In this case report, OFG is presented with a detailed differential diagnosis. Conclusions: OFG is a disorder with inconstant clinical presentations and can be related to other granulomatous diseases. It has an uncertain cause, which may be associated with systemic diseases and can cause significant esthetic and functional problems. It has an unpredictable response to treatment, so to yield better clinical results, correct diagnosis and early treatment are essential.

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“…The patient with oral Crohn's disease involvement suffer from linear and apthous ulcers, the lip swelling and characteristically have a cobblestone oral mucosa. A linear ulceration in the buccal vestibule surrounded by hyperplastic mucous is highly suggestive of Crohn’s disease 1 10 11. Patients with OFG present with variable symptoms.…”

Section: Discussionmentioning

confidence: 99%

Orofacial granulomatosis as a presenting feature of Crohn's disease

2015

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An 11-year-old girl was referred to oral medicine with persistent facial swelling. She was diagnosed with orofacial granulomatosis (OFG) and was treated conservatively for 7 years, with no evidence of systemic illness. Aged 17 she re-presented with a flare up of her OFG, watery diarrhoea and fluctuating febrile episodes. Inflammatory markers were raised and an MR enterogram revealed terminal ileal Crohn's disease. This case highlights that OFG may precede the onset of intestinal Crohn's disease.

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Crohn's disease: orofacial considerations and disease pathogenesis

Cited by 35 publications

References 137 publications

Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Gingival Manifestations of Orofacial Granulomatosis: A Rare Finding

Orofacial granulomatosis as a presenting feature of Crohn's disease

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