Crohn's Disease (Regional Enteritis) of the Large Intestine and its Distinction from Ulcerative Colitis

Excisional surgery with ileostomy for Crohn's colitis with particular reference to factors affecting recurrence

“…Nugent, Veidenheimer, Meissner, and Haggitt (1973) from the Lahey Clinic found only one recurrence (3.6 %) after general surgery and ileostomy in 28 patients followed for 10 to 15 years. Such reports seem to confirm early concepts that Crohn's disease could remain confined to the large bowel and that therefore low recurrence ' rates should follow excision of the colon (Wells, 1952;Brooke, 1959;Lockhart-Mummery and Morson, 1960). In contrast, Korelitz, Present, Alpert, Marshak, and Janowitz (1972) have shown a 46% recurrence rate when Crohn's colitis was treated by excision with ileostomy.…”

An epidemiological study of ulcerative colitis and regional enteritis in the Oxford area.

“…Their evidence, however, was based on surgical resection specimens from an undefined population. In the series described by LockhartMummery and Morson (1960), primary Crohn's disease of the colon in patients over 50 was of the localized or segmental type, the oldest patient with diffuse lesions being 47. Exclusion of cases of segmental colitis, right-sided colitis, and other 'mixed forms' from our age-specific incidence rates (Fig.…”

“…Lockhart-Mummery and Morson (1960) found that cases of Crohn's disease of the colon typically present with diarrhoea, rectal bleeding being unusual except when the rectum is involved. Cornes and Stecher (1961) have suggested that the incidence of primary Crohn's disease of the colon is higher in old age than that of ulcerative colitis.…”

Clinical and pathological analysis of colonic Crohn's disease, including a subgroup with ulcerative colitis-like features

“…13 Although some cases show classic histological features, such as strictures, non-necrotizing granulomas, transmural lymphoid aggregates, segmental and patchy disease, fissures, sinus tracts and fistulas, and perianal disease, others do not. 5,[18][19][20][21] In fact, some patients with isolated colonic Crohn's disease show few, if any, classic gross and microscopic features of this disorder, as outlined above, and, thus, resemble ulcerative colitis clinically and histologically. [19][20][21] These cases have been termed 'superficial Crohn's disease' or 'ulcerative colitislike Crohn's disease'.…”