Crohn's disease successfully treated with the paleolithic ketogenic diet

Tóth, Csaba D.; Dabóczi, Andrea; Howard, Mark; Miller, Nicholas J.; Clemens, Zsófia

doi:10.5348/ijcri-2016102-cr-10690

Cited by 17 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is known that plant oils, grains and dairy, among their other possible negative effects, may promote inflammation [17]. On the contrary, the paleolithic ketogenic diet, which is based on animal fat, meat and offal, seems to have an anti-inflammatory effect, as also seen in our other patients on the same diet [18][19][20][21][22][23][24][25]. In addition, while the classical ketogenic diet is known to induce nutrient deficiencies [29], the paleolithic ketogenic diet seems to supply optimal amounts of micronutrients as shown by the absence of deficiency symptoms and the normalization of laboratory parameters including iron, magnesium and vitamin levels, and normal function of the liver, kidney and thyroid gland.…”

Section: Discussionmentioning

confidence: 54%

“…Second, we put forward that excluding food items humans are not evolutionary adapted to (including all kind of vegetable oils, milk, dairy products, grains, nightshades, legumes and food additives) promote the normalization of the intestinal barrier function. Such a normalization of the intestinal permeability was seen in our previous patient with Crohn's disease and was also paralleled with clinical improvement [24]. Importantly, increased intestinal permeability has been suggested to promote tumorigenesis in colon cancer specifically and in the rest of the body too [35,36].…”

Section: Discussionmentioning

confidence: 58%

“…As such it may have the largest potential for boosting regeneration while producing no side effects and nutritional deficiencies. However, deviations from diet, as also in the case of another patient with Crohn's disease [24] may hinder regeneration.…”

Section: Discussionmentioning

confidence: 99%

“…An increasing number of studies, as also reviewed by a recent metaanalysis [15], indicate metabolic benefits of the human evolutionary diet also known as the stone age diet [16] or paleolithic diet [17]. In recent years we have published a series of case studies where type 1 diabetes [18,19], type 2 diabetes [20], epilepsy [21,22], Gilbert's syndrome [23] and Crohn's disease [24] where was successfully treated by the paleolithic ketogenic diet, an animal fat-meat based diet. In our most recent case study we reported on halted progression of soft palate cancer for 20 months in a patient on the paleolithic ketogenic diet [25].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Treatment of Rectal Cancer with the Paleolithic Ketogenic Diet: A 24-months Follow-up

Tóth¹,

Clemens²

2017

AJMCR

Self Cite

View full text Add to dashboard Cite

Background: Ketogenic diets have repeatedly been suggested for the treatment of cancer. Yet, only a few case studies have been published that reported long term benefits associated with such diets. Case report: Here we present a case where rectal cancer was treated with an animal fat-meat based diet, which we refer to as the paleolithic ketogenic diet. Upon diet initiation, the patient discontinued three medicines he had been taking because of hypertension and hyperuricemia. The patient initially received 6 weeks of radiation therapy. Thereafter the patient used the diet as a stand-alone therapy for 22.5 months. The patient was not taking any medicines or dietary supplements while on the diet. During the first five month of the diet therapy the patient exhibited excellent adherence which was paralleled by improving laboratory parameters including decreasing tumor marker levels and decreasing tumor size. The patient was in a constant ketosis during the entire follow-up. From the seventh month on, however, his adherence level was fluctuating with periods of worse adherence paralleled with negative changes in laboratory parameters. Although MRI imaging showed that there was no increase in the size of the tumor, 22 months after diagnosis onset the patient reported an alteration in bowel habits and that the bloody stool had returned. Because of the emergence of these symptoms, 24 months after diagnosis onset, rectal surgery was performed. Conclusion: With using the paleolithic ketogenic diet the patient was able to postpone surgery for two years. During the first five months, when the patient was strictly adhering to the diet, the tumor regressed. Thereafter, with incomplete dietary adherence, disease seemed to be stable but symptoms suggested progression for the last few months of the follow-up. Deviations from diet rules, even those not affecting ketosis, resulted in the progression of the disease.

show abstract

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Treatment of Rectal Cancer with the Paleolithic Ketogenic Diet: A 24-months Follow-up

Tóth¹,

Clemens²

2017

AJMCR

Self Cite

View full text Add to dashboard Cite

show abstract

“…As we previously reported, recovery from Crohn's disease using the paleolithic ketogenic diet may be hindered by eating components of the popular paleolithic diet [22]. In another case study we reported that the popular paleolithic diet did not confer all the benefits that were provided by the paleolithic ketogenic diet in Gilbert's syndrome [23].…”

Section: Discussionmentioning

confidence: 72%

Complete Cessation of Recurrent Cervical Intraepithelial Neoplasia (CIN) by the Paleolithic Ketogenic Diet: A Case Report

Tóth¹,

Schimmer²

2018

JCRT

Self Cite

View full text Add to dashboard Cite

Background: Ketogenic diets have repeatedly been suggested for the treatment of cancer. To date, only a few case studies reporting long term benefits associated with such diets have been published. Case report: Here we present a case where recurrent cervical intraepithelial neoplasia (CIN), a premalignant condition of cervical cancer, was successfully treated with the paleolithic ketogenic diet. The patient had a history of high grade CIN in 2011, which was successfully treated with cervical conization and fractional curettage. In October 2015 she was found to have a recurrence of high grade CIN (HSIL: High Grade Squamous Intraepithelial Lesion). The patient was then commenced on the paleolithic ketogenic diet and her repeat Pap (Papanicolaou) smear three months later was found to have reverted to normal. The patient has remained on the paleolithic ketogenic diet for 26 months, her repeat smears have stayed normal, and she is free of symptoms and side effects. Conclusion: We conclude that the diet was effective and safe in this patient. As a major benefit the patient was able to avoid a hysterectomy, which is the standard treatment for recurrent high-grade CIN. We believe that the paleolithic ketogenic diet combines benefits of both paleolithic and classical ketogenic diets, while excluding their disadvantages.

show abstract