Cronkhite‑Canada syndrome: A case report

Wei, Yuan; Liu, Tian; Ai, Feiyan; Liu, Shaojun; Shen, Shourong; Wang, Xiaoyan; Liu, Fen

doi:10.3892/ol.2018.8409

Cited by 4 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A több páciensnél is kimutatott emelkedett szérum-ANA-szint, a polypok szövettani vizsgálata során észlelt IgG4-pozitivitás és a társbetegségként gyakran megjelenő szisztémás lupus erythematosus és rheumatoid arthritis miatt autoimmun eredetet valószínűsítenek [3,7,12]. Triggerfaktorként a stressz, az immunrendszer működési zavara és a H. pylori fertőzés szerepe is felmerült [12,13].…”

Section: Megbeszélésunclassified

“…Szövettanilag hamartomatosus, hyperplasticus és gyulladásos polypok is előfordulhatnak. Jellemző kórszövettani elváltozás a lobsejtes beszűrődés, a jelentős submucosus oedema döntően a lamina propria rétegében és a mucosában tágult mirigyek [11,13,16].…”

Section: Megbeszélésunclassified

“…55%-os 5 éves mortalitás adja. A leggyakrabban előforduló szövődmények a súlyos cachexia, a gastrointestinalis vérzés, a visszatérő fertőzések és a pangásos szívelégtelenség [13,15]. Gyomor-bél rendszeri daganatok az esetek 10-20%-ában alakulnak ki.…”

Section: Esetismertetésunclassified

See 2 more Smart Citations

Cronkhite–Canada-szindróma

Nagy

Tóth

Theisz

et al. 2021

View full text Add to dashboard Cite

Összefoglaló. A Cronkhite–Canada-szindróma egy extrém ritka, nem öröklődő, gyomor-bél rendszeri polyposissal, fehérjevesztő enteropathiával és ectodermalis elváltozásokkal járó megbetegedés. A világon eddig összesen körülbelül 500 esetet jegyeztek fel. Az etiológia pontosan nem tisztázott, hátterében elsősorban autoimmun folyamatot feltételeznek. A diagnózis a páciens kórtörténetén, a fizikális vizsgálaton, az endoszkópos képen és a szövettani leleten alapul. A jelen közleményben egy 71 éves férfi beteg esetét mutatjuk be. A klinikai kép és az elvégzett vizsgálatok alapján a tünetek hátterében Cronkhite–Canada-szindrómát igazoltunk, majd a szakirodalomban leggyakrabban alkalmazott kombinált protonpumpagátló, kortikoszteroid és meszalazin adását vezettük be, illetve táplálásterápiát alkalmaztunk. Tudomásunk szerint Cronkhite–Canada-szindrómás beteg esete Magyarországon elsőként kerül ismertetésre. Orv Hetil. 2021; 162(11): 432–438. Summary. Cronkhite–Canada syndrome is an extremely rare, noninherited disease, characterized by gastrointestinal polyposis, protein-losing enteropathy and ectodermal abnormalities. Approximately 500 cases have been reported worldwide. The aetiology is unknown, most probably autoimmune mechanisms may be involved. The diagnosis is based on patient history, physical examination, endoscopic findings and histology. Here we report the case of a 71-year-old male, diagnosed with Cronkhite–Canada syndrome. The treatment consisted of proton-pump inhibitor, corticosteroids, mesalazin and nutritional therapy. To the best of our knowledge, this is the first report of Cronkhite–Canada syndrome in Hungary. Orv Hetil. 2021; 162(11): 432–438.

show abstract

Section: Megbeszélésunclassified

See 1 more Smart Citation

Cronkhite–Canada-szindróma

Nagy

Tóth

Theisz

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Cronkhite-Canada syndrome (CCS) is one of the rarest nonhereditary diseases[ 1 ], and its exact aetiology is still unknown[ 2 ], with around 500 cases having been described in the literature[ 3 ]. Most of CCS cases were reported from Japan, and to our knowledge, our case is the first case reported from Egypt and North Africa.…”

Section: Introductionmentioning

confidence: 99%

Cronkhite-Canada syndrome: First case report from Egypt and North Africa

Alzamzamy¹,

Aboubakr²,

Okasha³

et al. 2022

World J Gastrointest Endosc

View full text Add to dashboard Cite

BACKGROUND Gastrointestinal (GI) polyposis is a rare condition in GI diseases. To date about 500 cases of Cronkhite-Canada syndrome (CCS) have been reported worldwide. CASE SUMMARY We report a 60-year-old female patient who presented with dyspepsia, abdominal pain, and weight loss of 1-year duration. Her physical examination showed alopecia and onychodystrophy. Upper endoscopy revealed diffuse markedly thickened gastric mucosa involving the whole stomach with thickened gastric rugae and numerous polypoidal lesions. Histopathological examination showed marked hyperplasia of the foveolar glands with inflammatory cell infiltration. Endoscopic ultrasound showed a significantly hypertrophic mucosa and muscularis mucosa, while the submucosa and the muscularis propria were spared, favouring its benign nature. Colonoscopy showed multiple sessile polyps scattered at different parts of the colon. Histopathological examination revealed tubular adenomatous polyps with low-grade dysplasia. Differential diagnoses included CCS, Menterier disease (MD), other polyposis syndromes, lymphoma, amyloidosis, and gastric malignancies. The presence of alopecia, nail dystrophy, GI polyposis, markedly thickened gastric mucosa and folds, abdominal pain, weight loss, and marked foveolar gland hyperplasia; all was in favour of CCS. Lymphoma was excluded due to sparing of the muscularis propria. The presence of colonic polyps and antral and duodenal infiltration, and the absence of hypoproteinaemia decreased the possibility for MD. CONCLUSION The patient was diagnosed as having CCS.

show abstract

Cronkhite–Canada syndrome: from clinical features to treatment

Sang

Chang

2020

Gastroenterology Report

View full text Add to dashboard Cite

Cronkhite–Canada syndrome (CCS) is a rare acquired polyposis with unknown etiology. To date, >500 cases have been reported worldwide. CCS is typically characterized by gastrointestinal symptoms, such as diarrhea and skin changes (e.g. alopecia, pigmentation, and nail atrophy). Endoscopic features include diffuse polyps throughout the entire gastrointestinal tract, except for the esophagus. Pathological types of polyps in CCS mainly include inflammatory, hyperplastic, hamartomatous, and adenomatous polyps. CCS can be complicated by many diseases and has a canceration tendency with a high mortality rate. Moreover, there is no uniform standard treatment for CCS. A review of the reported cases of CCS is presented herein, with the goal of improving our understanding of this disease.

show abstract

Cronkhite‑Canada syndrome: A case report

Cited by 4 publications

References 19 publications

Cronkhite–Canada-szindróma

Cronkhite–Canada-szindróma

Cronkhite-Canada syndrome: First case report from Egypt and North Africa

Cronkhite–Canada syndrome: from clinical features to treatment

Contact Info

Product

Resources

About