Cronkhite-Canada syndrome associated withmyelodysplastic syndrome

Suzuki, Rei; Irisawa, Atsushi; Hikichi, Takuto; Takahashi, Yuta; Kobayashi, Hiroko; Kumakawa, Hiromi; Ohira, Hiromasa

doi:10.3748/wjg.15.5871

Cited by 10 publications

(8 citation statements)

References 10 publications

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“…Some reports started corticosteroid therapy with prednisolone, 40 mg/d and then tapered the dosage and added mesalazine, 1500 mg/d. 13 However other reports considered that oral maintenance administration of prednisolone might be better and improved the disappearance of diffuse gastrointestinal polyposis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Recurrent Cronkhite-Canada Syndrome Containing Colon Cancer

Zhu

Shi

Zhou

et al. 2015

International Surgery

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Cronkhite-Canada syndrome (CCS) is a very rare disease which may cause malignant transformation. A combination regimen including corticosteroids are common therapy for CCS, however the decrease of medicine may lead to CCS relapse and also may contribute to malignant transformation of the polyps in gastrointestinal tract. We retrospectively analyze one case of recurrent CCS from the first time of treatment after resection of colon cancer and readjust the usage of corticoids, the patient recovered well. The nine months follow-up showed non gastrointestinal tumor occurred or relapsed. We believe close follow-up should be taken when CCS patients are making medicine dosage alteration and tumor marker such as CEA may be included in the surveillance examination. When improvement using conservative treatment can be neither obtained nor is expected, the use of surgery should be considered.

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Section: Discussionmentioning

confidence: 99%

A Case of Recurrent Cronkhite-Canada Syndrome Containing Colon Cancer

Zhu

Shi

Zhou

et al. 2015

International Surgery

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“…The latter have included giant cell tumour of bone,96 cholangiocarcinoma,97 lung carcinoma (with metachronous oesophageal carcinoma),91 multiple myeloma98 and myelodysplastic syndrome 99…”

Section: Risk For Gi and Other Neoplasmsmentioning

confidence: 99%

Cronkhite–Canada syndrome six decades on: the many faces of an enigmatic disease

Slavík¹,

Montgomery

2014

J Clin Pathol

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Cronkhite–Canada syndrome is a rare gastro-entero-colopathy of uncertain aetiology first described almost 60 years ago. It is characterised by diffuse gastrointestinal polyposis sparing only the oesophagus, ectodermal abnormalities and an unpredictable but often fatal clinical course. The disease may demonstrate extremely diverse clinical and endoscopic features, which often leads to a delay in diagnosis. A high index of suspicion and recognition of the characteristic histological findings frequently facilitate a correct diagnosis, but the distribution of the gastrointestinal pathology and its microscopic features may be atypical. The pathologist thus requires a thorough knowledge of both the typical and many atypical faces of this disease, for which various documented therapies often still prove ineffective. Close correlation with clinical findings, including any pertinent ectodermal abnormalities, and careful examination of biopsies derived from polypoid and endoscopically spared mucosa will ensure a timely and correct diagnosis in patients with this enigmatic syndrome.

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“…There are two reported cases of CCS that were first treated as UC, just like our patient. UC is characterized by recurrent episodes of diarrhea, which is often bloody, with abdominal pain, malaise and weight loss .…”

Section: Discussionmentioning

confidence: 60%