Cronkhite-Canada Syndrome: Review of the Literature

Kopáčová, Marcela; Urban, Ondřej; Cyrany, Jiří; Laco, Ján; Bureš, Jan; Rejchrt, Stanislav; Bártová, Jolana; Tachecí, Ilja

doi:10.1155/2013/856873

Cited by 55 publications

(72 citation statements)

References 34 publications

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“…CCS is a rare disease, and only 450 cases have been described in the literature thus far since Cronkhite and Canada first reported two cases in 1955 (1,2). Approximately two-thirds of patients are of Japanese descent (3).…”

Section: Introductionmentioning

confidence: 99%

Cronkhite-Canada Syndrome Complicated by Triple Primary Cancers

et al. 2016

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We herein report a case of Cronkhite-Canada syndrome (CCS) complicated with triple primary cancers. The patient was diagnosed with CCS at 65 years of age. At 76 years of age, one of his colon polyps was diagnosed as adenocarcinoma. At 81 years of age, gastric carcinoma was detected. Weight loss and fatigue appeared one month before he visited our hospital. An examination revealed dilatation of the intrahepatic bile duct. Cholangiocarcinoma was diagnosed as a result of bile duct cytology. Patients with CCS should be monitored carefully for carcinoma of systemic organs as well as the gastrointestinal tract.

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Section: Introductionmentioning

confidence: 99%

Cronkhite-Canada Syndrome Complicated by Triple Primary Cancers

et al. 2016

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“…Differential diagnosis of CCS includes Menetrier disease, familial adenomatous polyposis, juvenile polyposis, Cowden syndrome, Peutz-Jeghers syndrome, inflammatory bowel disease, Whipple disease and small intestinal lymphoma (22)(23)(24). In the present case, the patient was initially diagnosed with familial polyposis, but eventually was diagnosed with CCS due to the dermatological triad of hyperpigmentation in oral mucosa (Fig.…”

Section: Discussionmentioning

confidence: 72%

Cronkhite-Canada syndrome: A case report

Rubio

Björk

2018

Journal of the American Academy of Dermatology

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Abstract. Cronkhite-Canada syndrome (CCS) is a rare non-inherited condition characterized by gastrointestinal (GI) hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, weight loss and diarrhea. The etiology is most likely autoimmune and diagnosis is based on patient history, physical examination, endoscopic findings of GI polyposis and histology. The disease is very rare; thus far more than 500 cases of CCS have been reported globally. A 58-years-old male with CCS was reported in the present case study. The patient experienced a history of diarrhea and hematochezia for 4 months, with abdominal pain for 1 month and additional nail and toenail loss for half a month. The clinical, endoscopic and histological data confirmed the diagnosis.

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“…Although there is no standardized treatment, current reports favor combined therapy based on nutritional support and corticosteroids. 9 We used oral prednisolone (30 mg/day) alone in the present case. One month after the initiation of prednisolone therapy the patient's symptoms markedly improved.…”

Section: Discussionmentioning

confidence: 99%

Cronkhite‐Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy

Namikawa

Takemoto

Kamata

et al. 2015

J of Gen and Family Med

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The etiology of and optimal treatments for Cronkhite‐Canada syndrome (CCS) are still undetermined. Fewer than 5% of CCS patients experience complete remission and 15% of CCS patients develop malignancies. Here, we present a case of CCS involving autoimmune disorders, in which rapid diagnosis, rapid commencement of therapy, and complete remission were achieved after 4 months of prednisolone therapy and polypectomy, although biopsy specimens from all residual colonic polyps revealed adenocarcinoma in one polyp 4 months after prednisolone therapy. It is important to identify gastrointestinal or colonic polyps harboring malignant changes and to examine the involvement of autoimmune mechanisms for better outcomes in CCS patients.

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Cronkhite-Canada Syndrome: Review of the Literature

Cited by 55 publications

References 34 publications

Cronkhite-Canada Syndrome Complicated by Triple Primary Cancers

Cronkhite-Canada Syndrome Complicated by Triple Primary Cancers

Cronkhite-Canada syndrome: A case report

Cronkhite‐Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy

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