Cross-border comparison of the admission prevalence and clonal structure of meticillin-resistant Staphylococcus aureus

Köck, Robin; Brakensiek, L; Mellmann, Alexander; Kipp, Frank; Henderikx, M; Harmsen, Dag; Daniels-Haardt, I.; Eiff, Christof von; Becker, Karsten; Hendrix, Martin; Friedrich, Alex

doi:10.1016/j.jhin.2008.12.001

Cited by 74 publications

(70 citation statements)

References 31 publications

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“…In the spa sequence typing method, each identified repeat is associated to a code and a spa-type is deduced from the order of specific repeats. Although spa-typing has a lower discriminatory ability than PFGE [45,46], its cost-effectiveness, ease of use, speed, excellent reproducibility, appropriate in vivo and in vitro stability, standardised international nomenclature, high-throughput by using the StaphType software, and full portability of data via the Ridom database (http:// spaserver.ridom.de) makes this method the currently most useful instrument for characterising S. aureus isolates at the local, national and international levels [47][48][49][50][51][52]. Importantly, this approach ensures strict criteria for internal and external quality assurance of data submitted to the database that is curated by SeqNet.org [50,53].…”

Section: Staphylococcus Aureus Protein a Gene-typingmentioning

confidence: 99%

Overview of molecular typing methods for outbreak detection and epidemiological surveillance

et al. 2013

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Typing methods for discriminating different bacterial isolates of the same species are essential epidemiological tools in infection prevention and control. Traditional typing systems based on phenotypes, such as serotype, biotype, phage-type, or antibiogram, have been used for many years. However, more recent methods that examine the relatedness of isolates at a molecular level have revolutionised our ability to differentiate among bacterial types and subtypes. Importantly, the development of molecular methods has provided new tools for enhanced surveillance and outbreak detection. This has resulted in better implementation of rational infection control programmes and efficient allocation of resources across Europe. The emergence of benchtop sequencers using next generation sequencing technology makes bacterial whole genome sequencing (WGS) feasible even in small research and clinical laboratories. WGS has already been used for the characterisation of bacterial isolates in several large outbreaks in Europe and, in the near future, is likely to replace currently used typing methodologies due to its ultimate resolution. However, WGS is still too laborious and time-consuming to obtain useful data in routine surveillance. Also, a largely unresolved question is how genome sequences must be examined for epidemiological characterisation. In the coming years, the lessons learnt from currently used molecular methods will allow us to condense the WGS data into epidemiologically useful information. On this basis, we have reviewed current and new molecular typing methods for outbreak detection and epidemiological surveillance of bacterial pathogens in clinical practice, aiming to give an overview of their specific advantages and disadvantages.

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Section: Staphylococcus Aureus Protein a Gene-typingmentioning

confidence: 99%

Overview of molecular typing methods for outbreak detection and epidemiological surveillance

et al. 2013

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“…However, the prevalence of LA-MRSA CC398 in these countries is still very low (Stefani et al, 2012). But in countries like Denmark, Netherland and Belgium, the report of MRSA CC398 in livestock is high (Köck et al, 2009a;Köck et al, 2009b). Epidemiological studies in UK indicate the spread of LA-MRSA into hospitals particularly in individuals with frequent animal contact (Paterson et al, 2012).…”

Section: Livestock-associated Mrsa (La-mrsa)mentioning

confidence: 99%

Methicillin Resistant Staphylococcus aureus (MRSA): A Review

Grema¹,

Geidam²,

Gadzama³

et al. 2015

Adv. Anim. Vet. Sci.

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“…Dabei wurde z. T. auch eine Erregertypisierung durchgeführt wie im Falle des MRSA-Netzwerkes Süd-Brandenburg (die Prävalenz von MRSA betrug hier 0,77 %; neben HA-MRSA stellten LA-MRSA 10 % dieser Isolate [4]). In Regionen mit einer hohen Dichte an Schweinemastbetrieben ist dieser Anteil höher (EUREGIO-Netzwerk Twente-Münsterland: MRSA-Prävelenz 1,6 %; daran Anteil von LA-MRSA ~30 % [5]). …”

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Aktuelle Daten und Trends zu Methicillin-resistenten Staphylococcus aureus (MRSA)

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Cuny

Strommenger

et al. 2012

Bundesgesundheitsbl.

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Cross-border comparison of the admission prevalence and clonal structure of meticillin-resistant Staphylococcus aureus

Cited by 74 publications

References 31 publications

Overview of molecular typing methods for outbreak detection and epidemiological surveillance

Overview of molecular typing methods for outbreak detection and epidemiological surveillance

Methicillin Resistant Staphylococcus aureus (MRSA): A Review

Aktuelle Daten und Trends zu Methicillin-resistenten Staphylococcus aureus (MRSA)

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