Cross-Cultural Validation of the Italian Version of the Bt-DUX: A Subjective Measure of Health-Related Quality of Life in Patients Who Underwent Surgery for Lower Extremity Malignant Bone Tumour

Abstract

The purpose of this study was to translate the English bone tumour DUX (Bt-DUX-Eng) questionnaire for lower extremity bone tumour patients, a disease-specific quality of life (QoL) instrument, into Italian and then examine the validity of the Italian version of Bt-DUX (Bt-DUX-It). The adaptation and translation process included forward translation, back-translation, and a review of the back-translation by an expert committee. The Bt-DUX-It was validated in a sample of adolescents treated for lower extremity osteosarcoma in Italy. Assessments included the Bt-DUX, the Toronto Extremity Salvage Score (TESS), and the European Organization for Research and Treatment Core Quality of Life Questionnaire of Cancer Patients (EORTC QLQ-C30). Fifty-one patients with a median age of 20 years (range: 15–25) completed the questionnaires. The mean Bt-DUX score was 70 (range: 16.30–100). The internal consistency of the overall score and that of the Bt-DUX-It was good: Cronbach’s α was 0.95. Spearman’s correlation coefficient between the Bt-DUX (total and domain scores) and EORTC QLQ C30 and TESS were overall moderate to good, reaching a p-value <0.01 in all cases. The Bt-DUX-It version is a useful tool for measuring QoL in patients with bone tumour and has similar internal consistency, construct validity, and discrimination as those of the Dutch and English versions.

Evaluation of fatigue and quality of life in patients with cancer of the musculoskeletal system undergoing chemotherapy treatment. An observational study

“…The global quality of life at 6 months showed a decreasing trend compared to that of the start of treatment time with an average of 59.3 and 50.2 respectively. In a cohort of patients affected by musculoskeletal cancer, comparable to that of the present study, with a follow-up of more than 3 years there was a GH-QoL equal to 83.3 [23]. This data highlighted how in a more prolonged follow-up it is possible to expect a signi cant recovery in the quality of life, whereas in the initial phase this aspect is strongly reduced and presents a decreasing trend which must be considered carefully.…”

Psychometric Analysis of the questionnaires for the assessment of lower limbs available in Italian version: a systematic review

“…Internal consistency of the seven Italian questionnaires ranging from 0.754 (21) to 0.95 (24) and they were found to be consistent with the versions translated into other languages, except for WOMAC italian questionnaire (22) that the value (cronbach alpha 0.81-0.91) was slightly lower than that of the Portuguese internal consistency (cronbach alpha 0.92-0.98) (57) version.…”

“…The seven questionnaires identi ed for evaluating the lower limbs have reliability values ranging from 0.507 (20) to 0.99 (21) reported by GSQ and UCLA respectively. No reliability tests were performed for the Italian version of the CPG and DUX questionnaire (19,24). For other questionnaires, this psychometric variable of the Italian version is in line with versions available in other languages, observing only some small differences such as for example: The reliability of the GSQ Italian version (ICC = 0.507) is lower than the Spanish version (ICC=0.87) and the reliability of the TESS Italian version (ICC=0.99) it is higher than they looked at the Chinese (55) (ICC=0.893) and Korean (56) (ICC=0.874) versions.…”

Bone and Soft Tissue Tumors: New Treatment Approaches

“…The bone tumor DUX (Bt-DUX) questionnaire is a useful tool for measuring quality of life in patients with bone tumors, which is easy to use in clinical practice. Morri et al translated the English bone tumor DUX for patients with lower extremity bone tumors into Italian, and evaluated the validity of the Italian version of Bt-DUX [ 20 ]. In their study, the Italian version showed a similar usefulness to the Dutch and English versions.…”