Background Electronic resources (e-resources) have considerable potential to reach users around the world to promote awareness and knowledge about musculoskeletal conditions. The ‘PMM portfolio’ targets non-specialists in musculoskeletal medicine and comprises the Paediatric Musculoskeletal Matters (PMM) website, the paediatric Gait, Arms, Legs and Spine (pGALS) app and e-learning modules (ELM). Our aim was to evaluate the ‘PMM portfolio’ to gain insights about it’s impact on learning and clinical practice. Methods Mixed methods (e-resource analytics, online survey, interviews) with PMM and ELM registered users in addition to purposive sampling of users using UK and international contacts within paediatrics and paediatric rheumatology. Data was analysed using descriptive statistics and free-text comments using qualitative techniques. A Paired T-Test compared self-rated confidence before and after use of the e-resources. Results There has been wide international reach for all e-resources PMM website (662,827 hits, 262,476 users, 214 countries, data 31st July 2020), pGALS app (12,670 downloads, 70 countries, data 31st July 2020); ELM (150 users, 30 countries, data 30th May 2019). There were 164 responses to the survey from 25 countries from a range of students, trainees and health care professionals. Most deemed the ‘PMM portfolio’ to be ‘useful or very useful’ for their learning (or when used to teach others) and reported significantly increased self-rated confidence in their clinical examination and reasoning skills following access to the e-resources (PMM website, p=<0.01; pGALS app, p=<0.01; ELM, p=<0.01). Easy, open access, clinical images, videos and cases were deemed the most valued features of the e-resources. The most popular PMM website pages related to clinical assessment. There was high uptake of the pGALS app and pGALS’ ELM especially from trainees and allied health professionals. Conclusions The ‘PMM portfolio’ has wide reach amongst a spectrum of our target users to raise awareness and improve knowledge and skills. Ongoing engagement with users will facilitate further iterations of the ‘PMM portfolio’ to remain relevant for the global context. PMM as a model of e-learning has increasing applicability with the ongoing Covid-19 pandemic and is an important way to expand global paediatric rheumatology.