Cross-cultural validity of the thyroid-specific quality-of-life patient-reported outcome measure, ThyPRO

Watt, Torquil; Barbesino, Giuseppe; Bjørner, Jakob Bue; Bonnema, Steen Joop; Bukvić, Branka; Drummond, Russell; Grøenvold, Mogens; Hegedűs, László; Kantzer, Valeska; Lasch, Kathryn Eilene; Marcocci, Claudio; Mishra, Anjali; Netea‐Maier, Romana T.; Ekker, Merel S.; Paunović, Ivan; Quinn, Terence J.; Rasmussen, Åse Krogh; Russell, Audrey; Mayilvaganan, Sabaretnam; Smit, Johannes W. A.; Törring, Ove; Živaljević, Vladan; Feldt‐Rasmussen, Ulla

doi:10.1007/s11136-014-0798-1

Cited by 56 publications

(57 citation statements)

References 43 publications

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“…Of the 17 DIFs in the 85-item version, presented in Table 2, all but one have been found in previous studies of DIF [8,33]; unique to Greek patients was a tendency to report more appetite than Danish patients at similar levels of hyperthyroidism symptoms.…”

Section: Discussionmentioning

confidence: 90%

“…In general, both ThyPROgr and ThyPRO-39gr performed well in the cross-validation study and now represent new tools for assessing patient-reported health outcomes in Greekspeaking patients. ThyPROgr and ThyPRO-39gr can be used in clinical studies and trials, including international multicenter studies, as ThyPRO is now available in several languages, all of which have been cross-culturally validated [8]. Another important aspect of ThyPRO is that it can be used as a monitoring and communication instrument in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…An item in a multi-item scale is subject to DIF if patients from different countries but with the same level of the measured attribute score differently on that item [19][20][21][22][23][24]. ThyPRO has previously been found to have good cross-cultural validity using DIF analyses [8]. Cross-cultural validity of the Greek translation was evaluated for both versions of ThyPRO.…”

Section: Methodsmentioning

confidence: 99%

“…The questionnaire consists of 85 items grouped in 14 scales concerning goiter, hypothyroidism, hyperthyroidism and eye symptoms, tiredness, cognitive impairment, anxiety, depression, emotional susceptibility, cosmetic complaints and impaired social, and daily and sex life, as well as overall quality of life [6]. ThyPRO was developed in Danish and English [6] and has been translated and culturally validated in German, Dutch, Italian, Swedish, French, Portuguese, Arabic, Simplified Chinese, Traditional Chinese, Tamil, Romanian, Bulgarian, Spanish, Hindi, Serbian, and Polish [7,8]. ThyPRO has been widely used to assess thyroid-related quality of life in patients with thyroid diseases [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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ThyPROgr: the Greek edition of the ThyPRO questionnaires for patients with benign thyroid diseases

et al. 2018

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The thyroid-related patient-reported outcome measure ThyPRO is currently the most reliable and valid instrument for the measurement of thyroid-related quality of life. The objective of the current study was to translate the original (85 items) and short (39 items) versions of ThyPRO into the Greek language as well as to validate and culturally adapt ThyPRO among the Greek population. Translation of patient-reported outcomes was done according to standard methodology. Following the translation process, the Greek version of ThyPRO (ThyPROgr) was validated in consecutive patients with thyroid diseases who visited the outpatient clinics of the Department of Endocrinology, "Hippokration" General Hospital, Thessaloniki, Greece, between September and December 2016. To test cross-cultural validity, analysis of differential item functioning (DIF) between the original Danish and the new Greek version, using ordinal logistic regression, was applied. Cross-cultural validity of the Greek translation was evaluated for both versions of ThyPRO. The ThyPRO questionnaire was validated in 143 consecutive patients (131 women and 12 men) with thyroid diseases, with a mean age of 62 ± 6 (SD) years. In the 85-item ThyPRO, 17 instances of DIF were detected, most of which were minor, this accounting for the~5% of the variation in scale score. Two instances of DIF among positively worded items were larger, with 8-10% of variance explained. For ThyPRO-39, five minor instances of DIF were found. As judged by the linguistic validation as well as the DIF analyses, ThyPROgr has good cross-cultural validity when compared with the original Danish version. The two versions of ThyPROgr can now be used to assess thyroid-specific quality of life in the Greek population.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ThyPROgr: the Greek edition of the ThyPRO questionnaires for patients with benign thyroid diseases

et al. 2018

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“…The questionnaire has been extensively validated for use in multiple languages, including Danish [29-31]. Individual scales of the questionnaire can be selected for measuring specific areas of interest [32].…”

Section: Methodsmentioning

confidence: 99%

Thyroidectomy Improves Tracheal Anatomy and Airflow in Patients with Nodular Goiter: A Prospective Cohort Study

Sørensen¹,

Lauridsen²,

Døssing³

et al. 2017

Eur Thyroid J

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Objective: A large goiter may cause compression of the trachea. The aim of this study was to investigate the impact of thyroidectomy on tracheal anatomy and airflow and to correlate this with changes in health-related quality of life (HRQoL) in patients with benign nodular goiter. Methods: Magnetic resonance images of the neck and respiratory flow-volume curves, including both inspiration and expiration, were performed prior to and 6 months following surgery. HRQoL was measured by selected scales from the thyroid-specific patient-reported outcome (ThyPRO). Cohen’s effect size (ES) was calculated as mean change divided by standard deviation at baseline. ES of 0.2–0.5 were defined as small, 0.5–0.8 as moderate, and values >0.8 as large. Results: Sixty-five patients completed all examinations. Median goiter volume was 58 mL (range, 14–642 mL) before surgery with surgical removal of a median of 43 g (range, 8–607 g). Six months after surgery, tracheal narrowing and deviation were diminished by a median of 26% (ES = 0.67, p < 0.001) and 33% (ES = 0.61, p < 0.001), respectively. Correspondingly, each 10% decrease in goiter volume resulted in 1.0% less tracheal narrowing (p < 0.001). Concomitantly, a small improvement was seen in forced inspiratory flow at 50% of forced vital capacity (ES = 0.32, p < 0.001). A reduction in tracheal narrowing was associated with improvements in the Impaired Daily Life scale (0.33 points per 1% decrease in tracheal narrowing, p = 0.03) of the ThyPRO questionnaire. Conclusions: In patients with symptomatic benign nodular goiter, thyroidectomy resulted in substantial improvements in tracheal anatomy and improvements in inspiratory flow, which were followed by gains in HRQoL. This information is pertinent when counseling patients before choice of treatment.

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Quality of life is not affected by thyroid surgery in nontoxic benign goitre in long‐term surveillance—A prospective observational study

Tabriz

Uslar

Tabriz

et al. 2020

Endocrino Diabet & Metabol

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Objective: Quality of life (QoL) has so far seldom been taken into account by default in decision-making for surgical indication in thyroid surgery. Therefore, we compared pre-and postoperative QoL of patients using the EuroQoL-5D (EQ-5D) questionnaire. The influence of certain socio-economic factors on QoL as a second end-point was considered.Design: Prospective cohort study.Patients: About 153 patients with euthyroid symptomatic benign goitre after hemiand total thyroidectomy (follow-up 83.6%) have been included. Measurements:The EQ-5D questionnaire was used prior to and 1 year after surgery.In addition, a questionnaire for assessment of socio-economic status was collected. Results: For n = 90 (n = 67 female, n = 23 male), total thyroidectomy (TT) and, for n = 63 (n = 45 female, n = 18 male), hemithyroidectomy (HT) were performed. None permanent dysfunction of the vocal cord was recorded. Transient symptomatic hypocalcaemia was detected in 9% of the thyroidectomy group (8/90 patients). At follow-up, 86% of patients showed either no change or improved QoL. About 14% of patients complained of deteriorated QoL, regardless of the extent of surgery. Socioeconomic factors did not influence postoperative QoL. Conclusions:Results indicate that in pre-operative consultation of patients with benign goitre, the improvement of QoL should be taken into account for decision-making in cases of ambiguous surgical indication. Contrary to current discussions that too much thyroid surgery is performed in Germany, we can recommend presenting surgery as an equivalent option to watchful waiting as QoL is at least preserved or improved. The extension of the resection should, however, be decided individually. K E Y W O R D SEQ-5D, health-related quality of life, hemithyroidectomy, patient-reported outcome, PRO, QoL, total thyroidectomy

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Cross-cultural validity of the thyroid-specific quality-of-life patient-reported outcome measure, ThyPRO

Abstract: The ThyPRO has good cross-cultural validity with only minor cross-cultural invariance and is recommended for use in international multicenter studies.

Cited by 56 publications

References 43 publications

ThyPROgr: the Greek edition of the ThyPRO questionnaires for patients with benign thyroid diseases

ThyPROgr: the Greek edition of the ThyPRO questionnaires for patients with benign thyroid diseases

Thyroidectomy Improves Tracheal Anatomy and Airflow in Patients with Nodular Goiter: A Prospective Cohort Study

Quality of life is not affected by thyroid surgery in nontoxic benign goitre in long‐term surveillance—A prospective observational study

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