Cross-examination of liquid–liquid extraction (LLE) and solid-phase microextraction (SPME) methods for impurity profiling of methamphetamine

Lee, Jaesin; Park, Yonghoon; Yang, Wenjun; Chung, Heesun; Choi, Won Jun; Inoue, Hiroyuki; Kuwayama, Kenji; Park, Jeong-Hill

doi:10.1016/j.forsciint.2011.01.042

Cited by 18 publications

(6 citation statements)

References 10 publications

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“…Amphetamines and related compounds have usually been extracted from urine samples by liquid-liquid extraction (LLE) [17][18][19], supercritical fluid extraction (SFE) [20], solid-phase extraction (SPE) [21,22], and solid-phase microextraction (SPME) [23][24][25]. However, there are several disadvantages of conventional extraction procedures such as LLE and SPE.…”

Section: Introductionmentioning

confidence: 99%

Solid-phase extraction followed by dispersive liquid-liquid microextraction for the sensitive determination of ecstasy compounds and amphetamines in biological samples

Mashayekhi¹,

Rezaee²,

Khalilian³

2014

Bull. Chem. Soc. Eth.

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ABSTRACT. A novel approach for the determination of ecstasy and amphetamines (3,4-methylenedioxymethylamphetamine (MDMA, Ecstasy), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxyethylamphetamine (MDEA) and 3,4-methylenedioxypropylamphetamine (MDPA)) in biological samples is presented. The analytes were extracted from the matrix and transferred to a small volume of a high density, water insoluble solvent using solid-phase extraction (SPE) followed by dispersive liquid-liquid microextraction (DLLME). This combination not only resulted in a high enrichment factor, but also it could be used in complex matrices (biological samples). Some important extraction parameters, such as sample solution flow rate, sample pH, type and volume of extraction and disperser solvents as well as the salt addition, were studied and optimized. Under the optimized conditions, the calibration graphs were linear in the range of 0.5-500 µg L -1 and 1.0-500 µg L -1 with detection limits in the range of 0.1-0.3 µg L -1 and 0.2-0.7 µg L -1 in urine and plasma samples, respectively. The results showed that SPE-DLLME is a suitable method for the determination of ecstasy components and amphetamines in biological and water samples.

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Section: Introductionmentioning

confidence: 99%

Solid-phase extraction followed by dispersive liquid-liquid microextraction for the sensitive determination of ecstasy compounds and amphetamines in biological samples

Mashayekhi¹,

Rezaee²,

Khalilian³

2014

Bull. Chem. Soc. Eth.

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“…Volatile IMPs could be identified only by SPME and non-volatile IMPs were identified by LLE. The study demonstrated that both SPME and LLE could be applied to the characterization of all IMPs [78]. It was a challenge to develop analytical methods for topiramate formulations because the compounds of interest did not have chromophores active above 190 nm and because of interference from excipients.…”

Section: The Conventional Approach To Structural Characterizationmentioning

confidence: 99%

A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products

Singh

Handa

Narayanam

et al. 2012

Journal of Pharmaceutical and Biomedical Analysis

188

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“…Sample preparation is oen required before instrumental analysis. Solid phase extraction (SPE), 12,18 solid phase microextraction (SPME), 19,20 and liquid-liquid extraction (LLE) 20,21 are traditional technologies and are currently widely used as pretreatment techniques. Two of these techniques are currently used for analyzing amphetamines but all the three technologies have certain limitations.…”

Section: Introductionmentioning

confidence: 99%

A simplified fabric phase sorptive extraction method for the determination of amphetamine drugs in water samples using liquid chromatography-mass spectrometry

Ruan

Li-mei

et al. 2020

RSC Adv.

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Cross-examination of liquid–liquid extraction (LLE) and solid-phase microextraction (SPME) methods for impurity profiling of methamphetamine

Cited by 18 publications

References 10 publications

Solid-phase extraction followed by dispersive liquid-liquid microextraction for the sensitive determination of ecstasy compounds and amphetamines in biological samples

Solid-phase extraction followed by dispersive liquid-liquid microextraction for the sensitive determination of ecstasy compounds and amphetamines in biological samples

A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products

A simplified fabric phase sorptive extraction method for the determination of amphetamine drugs in water samples using liquid chromatography-mass spectrometry

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