Cross-interactions between two members of the Dlx family of homeobox-containing genes during zebrafish development

Zerucha, Ted; Müller, Jürg; Chartrand, Nathalie; Ekker, Marc

doi:10.1139/o97-076

Cited by 15 publications

(1 citation statement)

References 35 publications

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“…Thus it is unlikely that dlx3b is involved in epithelialmesenchymal signaling required in many instances of bone formation (Hall, 2005). Of interest, Zerucha et al (1997) report that overexpression of truncated forms of dlx3b were found to result in perturbations in dlx5a expression in zebrafish and that cotransfection experiments indicate the ability of dlx3b to activate transcription of dlx5a. This might suggest that dlx5a is one of the target genes of dlx3b in embryos.…”

Section: Epithelial Expression Of Dlx3bmentioning

confidence: 99%

Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): Differential involvement in the visceral skeleton and braincase

Verreijdt

Debiais-Thibaud

Borday-Birraux

et al. 2006

Developmental Dynamics

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We have used dlx genes to test the hypothesis of a separate developmental program for dermal and cartilage bones within the neuro-and splanchnocranium by comparing expression patterns of all eight dlx genes during cranial bone formation in zebrafish from 1 day postfertilization (dPF) to 15 dPF. dlx genes are expressed in the visceral skeleton but not during the formation of dermal or cartilage bones of the braincase. The spatiotemporal expression pattern of all the members of the dlx gene family, support the view that dlx genes impart cellular identity to the different arches, required to make arch-specific dermal bones. Expression patterns seemingly associated with cartilage (perichondral) bones of the arches, in contrast, are probably related to ongoing differentiation of the underlying cartilage rather than with differentiation of perichondral bones themselves. Whether dlx genes originally functioned in the visceral skeleton only, and whether their involvement in the formation of neurocranial bones (as in mammals) is secondary, awaits clarification. Developmental Dynamics 235:1371-1389, 2006.

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Section: Epithelial Expression Of Dlx3bmentioning

confidence: 99%

Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): Differential involvement in the visceral skeleton and braincase

Verreijdt

Debiais-Thibaud

Borday-Birraux

et al. 2006

Developmental Dynamics

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DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation

et al. 1999

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The homeobox genes in the Dlx family are required for differentiation of basal forebrain neurons and craniofacial morphogenesis. Herein, we studied the expression of Dlx‐1, Dlx‐2, and Dlx‐5 RNA and protein in the mouse forebrain from embryonic day 10.5 (E10.5) to E12.5. We provide evidence that Dlx‐2 is expressed before Dlx‐1, which is expressed before Dlx‐5. We also demonstrate that these genes are expressed in the same cells, which may explain why single mutants of the Dlx genes have mild phenotypes. The DLX proteins are localized primarily to the nucleus, although DLX‐5 also can be found in the cytoplasm. During development, the fraction of Dlx‐positive cells increases in the ventricular zone. Analysis of the distribution of DLX‐1 and DLX‐2 in M‐phase cells suggests that these proteins are distributed symmetrically to daughter cells during mitosis. We propose that DLX‐negative cells in the ventricular zone are specified progressively to become DLX‐2‐expressing cells during neurogenesis; as these cells differentiate, they go on to express DLX‐1, DLX‐5, and DLX‐6. This process appears to be largely the same in all regions of the forebrain that express the Dlx genes. In the basal telencephalon, these DLX‐positive cells differentiate into projection neurons of the striatum and pallidum as well as interneurons, some of which migrate to the cerebral cortex and the olfactory bulb. J. Comp. Neurol. 414:217–237, 1999. © 1999 Wiley‐Liss, Inc.

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Perspectives on the evolutionary origin of tetrapod limbs

Capdevila

Belmonte

2000

J. Exp. Zool.

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The study of the origin and evolution of the tetrapod limb has benefited enormously from the confluence of molecular and paleontological data. In the last two decades, our knowledge of the basic molecular mechanisms that control limb development has grown exponentially, and developmental biologists now have the possibility of combining molecular data with many available descriptions of the fossil record of vertebrate fins and limbs. This synthesis of developmental and evolutionary biology has the potential to unveil the sequence of molecular changes that culminated in the adoption of the basic tetrapod limb plan. J. Exp. Zool. (Mol. Dev. Evol.) 288:287–303, 2000. © 2000 Wiley‐Liss, Inc.

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Cross-interactions between two members of the Dlx family of homeobox-containing genes during zebrafish development

Cited by 15 publications

References 35 publications

Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): Differential involvement in the visceral skeleton and braincase

Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): Differential involvement in the visceral skeleton and braincase

DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation

Perspectives on the evolutionary origin of tetrapod limbs

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