Abstract-The revolutionary trend of the up-to-date medicine can be formulated as wide introduction into basic medicine fields of electronic (e-health) and mobile (m-health) healthcare services and information applications. Unfortunately, all list of qualified m/e-healthcare services can be provided cost-effectively only in urban areas very good covered by broadband 4G/5G wireless communications. Unacceptably high investments are required into deployment of the optic core infrastructure for ubiquitous wide covering of sparsely populated rural, remote, and difficult for access (RRD) areas using the recent (4G) and forthcoming (5G) broadband radio access (RAN) centralized techniques, characterized by short cells ranges, because their profitability boundary exceeds several hundred residents per square km. Furthermore, the unprecedented requirements and new features of the forthcoming Internet of Things (IoT), machine-to-machine (M2M), and many other machine type IT-systems lead to a breakthrough in designing extremely green, flexible, and costeffective technologies for future 5G wireless systems which will be able to reach in real time the performance extremums, tradeoff optimums and fundamental limits. This paper examines the 5G PHY-MAC fundamentals and extremely approaches to creation of the profitable ubiquitous remote e/m-health services and telemedicine as the main innovation technology of popular healthcare and other social e-Applications for RRD territories. Proposed approaches lean on summarizing and develop the results of our previous works on RRD-adapted profitable ubiquitous green 4G/5G wireless multifunctional technologies.