2018
DOI: 10.1242/dev.164210
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Cross-limb communication during Xenopus hind-limb regenerative response: non-local bioelectric injury signals

Abstract: Regeneration of damaged body parts requires coordination of size, shape, location and orientation of tissue with the rest of the body. It is not currently known to what extent injury sites communicate with the remaining soma during repair, or what information may emanate from the injury site and reach other regions. We examined the bioelectric properties (resting potential gradients in the epidermis) of froglets undergoing hindlimb amputation and observed that the contralateral (undamaged) limb exhibits appare… Show more

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Cited by 36 publications
(35 citation statements)
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“…influences may be sought in other cases, for example in the propagation of bioelectric states during limb injury (Busse et al, 2018) or cancer (Chernet and Levin, 2014;Chernet et al, 2015). Moreover, it provides the minimal necessary condition to recapitulate such tissue propagation signals in synthetic bioengineering contexts (McNamara et al, 2016(McNamara et al, , 2018.…”
Section: Discussionmentioning
confidence: 99%
“…influences may be sought in other cases, for example in the propagation of bioelectric states during limb injury (Busse et al, 2018) or cancer (Chernet and Levin, 2014;Chernet et al, 2015). Moreover, it provides the minimal necessary condition to recapitulate such tissue propagation signals in synthetic bioengineering contexts (McNamara et al, 2016(McNamara et al, , 2018.…”
Section: Discussionmentioning
confidence: 99%
“…One of the remarkable aspects of Burr's prescient work on the bioelectrics of cancer was that he was able to measure the presence of tumors at a considerable distance. 170 Recent molecular work has begun to corroborate this finding with modern tools: bioelectric signals in non-neural tissues propagate long range within the body, carrying information about injury, 171 proliferation/apoptosis, 172 and regulating the ability of oncogene expression to convert cells into tumors. 173,174 This is consistent with a view of cancer as a reversion of cells to an ancient unicellular state, in which the cell views the rest of the body as just an external environment, 175,176 and the increasingly apparent role of bioelectric signals in mediating the long-range communication that normally harnesses individual cells into a larger whole-the metazoan organism and its target morphology.…”
Section: Long-range Propagation Of Oncogenic Signalsmentioning
confidence: 99%
“…Discovery science in the field of appendage regeneration has merged classic experimental methods like tissue grafting and genetic screens with modern technologies that deconstruct regeneration to context-dependent behaviors of individual cells, gene products and DNA regulatory sequences. Holistic ideas are also revealing insights into how communication between distant tissues can influence regeneration (Busse et al, 2018;Kang et al, 2013;Rodgers et al, 2014). The new mechanistic vantage points reached by contemporary studies, coupled with the evolution of delivery methods with better-than-surgical precision, will provide beacons for the journey ahead.…”
Section: Discussionmentioning
confidence: 99%