Cross-linkable, thermo-responsive Pluronic® building blocks for biomedical applications: Synthesis and physico-chemical evaluation

Vandenhaute, Mieke; Schelfhout, Jorg; Vlierberghe, Sandra Van; Mendes, Eduardo; Dubruel, Peter

doi:10.1016/j.eurpolymj.2014.01.016

Cited by 23 publications

(17 citation statements)

References 48 publications

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“…Dynamic light scattering (DLS) confirms that the surfactants remain water soluble and form micelles of similar diameter (see Table ) after acquiring an acrylate group. Fourier‐transform infrared (FTIR) spectra (shown in the Supporting Information) replicate prior work and demonstrate the loss of the IR band (3500 cm −1 ) from hydroxyl groups initially present and the evolution of bands (1640 and 1720 cm −1 ) corresponding to acrylate functional groups after the reaction with acryloyl chloride.…”

Section: Resultssupporting

confidence: 68%

“…Integrating micelle templated hydrophobic domains into hydrogel matrices requires that the surfactants are capable of being chemically bonded to the matrix. A variety of functional groups can be used, but here we add an acrylate group to the hydrophilic end of the surfactant, as done previously, for its compatibility with PEGDA‐based hydrogels. One exception is surfactant B25, which was purchased in the acrylated form.…”

Section: Resultsmentioning

confidence: 99%

“…The core of surfactant micelles has been used previously to create hydrophobic nanodomains . Several studies have modified poloxamer surfactants with acrylate groups to cross‐link micelles into hydrogels, which can encapsulate and release hydrophobic APIs . However, these initial designs of micelle‐laden hydrogels never incorporated crystalline API and suffered from restrictively low drug loading and slow release kinetics that limit their utility as OSDs.…”

Section: Introductionmentioning

confidence: 99%

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Photopolymerized Micelle‐Laden Hydrogels Can Simultaneously Form and Encapsulate Nanocrystals to Improve Drug Substance Solubility and Expedite Drug Product Design

Godfrin

Lee

et al. 2019

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converting an API to a salt, but many APIs are not compatible with this type of chemical transformation. [13] Therefore, formulation nanotechnologies are a more general and powerful approach to improve the solubility and absorption, distribution, meta bolism, and excretion properties of hydrophobic APIs toward improving clinical performance. In contrast, current nanomedicines have primarily focused on targeted delivery (e.g., cellular uptake) of oncology drugs, [14] albeit with slow and expensive development. [15] Solubility enhancement requires a sensitive balance of API solid state stability and the solubility in aqueous solution. Approaches such as lipid-based systems (such as self-emulsifying drug delivery systems), [16,17] cyclodextrin complexation, [18] and nanovehicles (micelles, liposomes, or dendrimers) [19] improve solubility by introducing a more hydrophobic interface onto which the API partitions in equilibrium with the aqueous solution. However, these co-solutes can hinder API-target binding if partitioning is too effective and also yield low API loading and toxicity concerns due to significant excipient content. [20] Methods such as nanocrystal formation, [4,[21][22][23] amorphous polymer nanoparticles, [24] and porous nanoparticles [5,25] improve the solubility and dissolution rate by stabilizing the API in a state with high surface energy (that depends on API particle size, crystallinity, and polymorph). [26,27] Of the available formulation nanotechnologies, nanocrystal formation has been the most successful for hydrophobic APIs and is used in several food and drug administrationapproved products. [4,21,22] By retaining the crystalline structure, nanocrystals are more stable than amorphous API and are relatively stable to polymorph transformations. [28] Nanocrystals can be synthesized with sizes as small as 100 nm with minimal stabilizer material to limit toxicity and increase drug loading. [4,22,[29][30][31] The large curvature and surface area of nanocrystals provide a driving force for higher solubility (Ostwald-Freundlich equation) and correspondingly faster dissolution (Noyes-Whitney equation) relative to particles on the micrometer scale or larger. [32] In the case of orally delivered nanocrystals, absorption and thus bioavailability are directly correlated with solubility and dissolution rate. [4] An improved dissolution rate also contributes Formulation technologies are critical for increasing the efficacy of drug products containing poorly soluble hydrophobic drugs, which compose roughly 70% of small molecules in commercial pipelines. Nanomedicines, such as nanocrystal formulations and amorphous solid suspensions, are effective approaches to increasing solubility. However, existing techniques require additional processing into a final dosage form, which strongly influences drug delivery and clinical performance. To enhance hydrophobic drug product efficacy and clinical throughput, a hydrogel material is developed as a sacrificial template to simultaneously form and encapsulate nanocrystal...

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Section: Resultssupporting

confidence: 68%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Photopolymerized Micelle‐Laden Hydrogels Can Simultaneously Form and Encapsulate Nanocrystals to Improve Drug Substance Solubility and Expedite Drug Product Design

Godfrin

Lee

et al. 2019

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“…3b, f, S3b and S4b, ESI †). 34,35 The new peak was not observable in spectrums of the dust particles or liquid polymers alone. Therefore, we speculated that the peak was the resultant of molecular interactions between mineral particles and PEO-PPO-PEO polymers, specically caused by the PPO block.…”

Section: Resultsmentioning

confidence: 87%

Liquid amphiphilic polymer for effective airborne dust suppression

et al. 2019

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“…These hydrophilic matrices absorb water when placed in an aqueous medium and, due to chain polymer relaxation, release the drug loaded through the spaces or channels within the hydrogel network [136,137]. Owing to their good biocompatibility and biodegradability, which are similar to natural tissues, hydrogels own several applications in biomedical and pharmaceutical fields [138,139]. Buccal infections such as periodontal [140], fungal [141,142] and inflammatory [143] diseases have often been treated by using mucoadhesive hydrogels as drug carriers.…”

Section: Semisolid Dosage Forms: Hydrogelsmentioning

confidence: 99%