Cross-linked amylose as matrix for drug controlled release. X-ray and FT-IR structural analysis

Dumoulin, Yves; Alex, Serge; Szabo, Pompilia Ispas; Cartilier, L.; Mateescu, Mircea Alexandru

doi:10.1016/s0144-8617(98)00058-7

Cited by 89 publications

(41 citation statements)

References 18 publications

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“…The sustained release properties of crosslinked and substituted high amylose corn starch matrices and their swelling behavior in media with various pH and ionic strengths has been reported by Mulhbacher et al [232]. The matrix characteristics of cross-linked high amylose starches have been studied by Dumoulin et al [233] and Le Bail et al [229]. The reasons for starch acting as a sustained release agent is due to its gel-forming ability, biodegradability, and biocompatibility [234].The molecular structure of the gel layer and the mechanical and physicochemical characteristics of the matrix such as gel strength and porosity contribute to the sustained release properties of the matrix.…”

Section: Starch or Starch Based Derivativesmentioning

confidence: 93%

Water Soluble Polymers for Pharmaceutical Applications

2011

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Advances in polymer science have led to the development of novel drug delivery systems. Some polymers are obtained from natural resources and then chemically modified for various applications, while others are chemically synthesized and used. A large number of natural and synthetic polymers are available. In the present paper, only water soluble polymers are described. They have been explained in two categories (1) synthetic and (2) natural. Drug polymer conjugates, block copolymers, hydrogels and other water soluble drug polymer complexes have also been explained. The general properties and applications of different water soluble polymers in the formulation of different dosage forms, novel delivery systems and biomedical applications will be discussed.

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Section: Starch or Starch Based Derivativesmentioning

confidence: 93%

Water Soluble Polymers for Pharmaceutical Applications

2011

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“…Amylose with a dysregulatory concentration of more than 10 results in cross-linked amylose showing a decrease in drug release time. The three-dimensional structure of amylose hydrogel with high STMP concentrations resulted in a more split structure when compared to amylose with low-tomoderate STMP concentrations [15]. The structure causes water to penetrate more easily so the tablet expands faster.…”

Section: Drug Release (Dissolution) Testmentioning

confidence: 98%

“…Administrated amylose with low-to-moderate STMP concentrations will result in a closer chain linkage by strengthening hydrogen bonds with strong covalent bonds. At high concentrations of STMP, many glycemic bridges are found in chains, hydrogen bonds are blocked, and chain links are more loosely coupled with intermediate chain regulation, so the larger the index expands [15].…”

Section: Index Expands Tablet Formulamentioning

confidence: 99%

Enzymatic Degradation of Cross-Linked Excipient Matrix of Co-Processed Xanthan Gum-Amylose and Dissolution Profile of Diclofenac Sodium Tablet

2017

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Objectives: This study aims to determine the amount of excipient that is degraded by alpha-amylase and the influence of alpha-amylase to the dissolution profile of sustained-release tablets that use matrix CL-Co-A-XG.Methods: Excipient is cross-linked with two concentrations of sodium trimetaphospate, which are 6% (CL6-Co-A-XG) and 12% (CL12-Co-A-XG). Each excipient is made with the ratios 1:1, 1:2, and 2:1 amylose-xanthan gum. Enzymatic degradation tests are performed on excipient powders for 60 minutes. Sustained-release tablet with CL-Co-A-XG excipient as a matrix is formulated through direct compression method. Then, drug dissolution tests are performed in a phosphate buffer with a pH of 7.4 both using and without using alpha-amylase as a medium for 8 hrs. Results:The results of this study show that CL6-Co-A-XG and CL12-Co-A-XG degraded 20% at 10 and 30 minutes, respectively. In addition, the release profile of F1-F6 tablets show the sustained-release profile that follows zero-order and Korsmeyer-Peppas kinetics and is unaffected by the presence of alpha-amylase. Conclusions:From this study, it can be concluded that the CL-Ko-A-XG excipients are more resistant to enzymatic degradation than amylose. Therefore, this excipient shows potential as a single matrix sustained-release tablet.

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“…Cross-linked high amylose starch (CLHAS) was introduced in the early 1990s as a tablet excipient for drug controlled release with the brand name Contramid Õ (Lenaerts et al, 1991(Lenaerts et al, , 1998Dumoulin et al, 1998). CLHAS is generally derived from the cross-linking of high amylose starch (70% amylose, 30% amylopectin) with epichlorohydrin or phosphate (Rahmouni et al, 2001).…”

Section: Cross-linked Starchmentioning

confidence: 99%

Recent advances of starch-based excipients used in extended-release tablets: a review

Yan

Liu

2014

Drug Delivery

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In recent years, polysaccharides, including starch and its derivatives, have been widely used in the pharmaceutical industry, including as diluents, fillers, binders, disintegrants and glidants. The use of native starch as excipient in extended-release tablets is limited due to its low compactibility and enzymatic degradability, leading to the formation of weakly structured tablets. To overcome these limitations and expand the application of starch as an excipient, researchers have modified starch by physical and chemical methods, as well as by enzymatic hydrolysis. Some starch derivatives, including retrograded starch, pregelatinized starch, carboxymethyl starch, starch acetate, cross-linked starch and grafted starch have recently been introduced as excipients in oral tablets to control drug release. In this review, applications of starch and its derivatives as extended release excipients are reviewed and future frontiers are described.

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Cross-linked amylose as matrix for drug controlled release. X-ray and FT-IR structural analysis

Cited by 89 publications

References 18 publications

Water Soluble Polymers for Pharmaceutical Applications

Water Soluble Polymers for Pharmaceutical Applications

Enzymatic Degradation of Cross-Linked Excipient Matrix of Co-Processed Xanthan Gum-Amylose and Dissolution Profile of Diclofenac Sodium Tablet

Recent advances of starch-based excipients used in extended-release tablets: a review

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