Cross-linked amylose tablets containing α-amylase: an enzymatically-controlled drug release system

Preparation and characteristics of high-amylose corn starch/pectin blend microparticles: A technical note

“…14 A cross-linking method has been applied to HACS and extensively studied for the controlled drug release applications. [15][16][17] Preparation of cross-linked HACS microparticles by the methods other than spray drying involves a tedious process and is unsuitable for large-scale production in the pharmaceutical industry. The process involving simple preparative procedures is preferred for the preparation of sustained-release carriers in the pharmaceutical industries.…”

High-amylose carboxymethyl starch matrices for oral sustained drug-release: In vitro and in vivo evaluation

“…Indeed, native starches are not suitable for SR drug delivery systems because of their poor flow and compressibility and, especially, their fast release properties, which are a result of substantial swelling in aqueous media along with rapid enzymatic degradation by α-amylase in physiological fluids Dumoulin, Cartilier et al 1999). …”

“…The agent usually used is epichlorohydrin (Lenaerts, Dumoulin et al 1991;Moussa and Cartilier 1997;Dumoulin, Alex et al 1998;Lenaerts, Moussa et al 1998;Dumoulin, Cartilier et al 1999), though trisodium trimetaphosphate, adipic-acetic anhydride and phosphorus oxychloride have also been mentioned (Dumoulin, Carriere et al 1998). …”

Properties of Tableted High-Amylose Corn Starch–Pectin Blend Microparticles Intended for Controlled Delivery of Diclofenac Sodium

“…To overcome the problems of pectin dissolution, pectin is usually combined with ethyl cellulose, Eudragit Õ , sodium alginate, and chitosan [1,2]. Controlled release formulations of cross-linked HACS are thoroughly investigated [14][15][16]. In this study, an effort is made to prepare noncross-linked HACS controlled release tableted formulation by blending gelatinized HACS with pectin.…”