Cross‐linked and non‐cross‐linked collagen barrier membranes disintegrate following surgical exposure to the oral environment: a histological study in the cat

Tal, Haim; Artzi, Zvi; Nemcovsky, Carlos E.; Moses, Ofer

doi:10.1111/j.1600-0501.2008.01546.x

Cited by 85 publications

(100 citation statements)

References 42 publications

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“…In an experimental study in cats, collagen matrices were either placed into a pocket for submerged healing or were exposed to the oral environment (Tal et al, 2008). Both modalities healed uneventfully, but the degradation process was faster in open healing sites.…”

Section: Discussionmentioning

confidence: 99%

Palatal wound healing using a xenogeneic collagen matrix – histological outcomes of a randomized controlled clinical trial

Thoma

Hilbe

Bienz

et al. 2016

J Clinic Periodontology

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AIM The aim of this study was to test whether or not a collagen matrix can improve early wound healing compared to spontaneous healing based on histological and immunohistologic analyses. METHODS In 20 volunteers, 6 mm punch biopsies were harvested at the palate. A xenogeneic collagen matrix (XCM) was sutured in one site; the other one was left untreated (control). Biopsies with a diameter of 8 mm were subsequently obtained at 4, 8, 15 and 29 days and histological and immunohistologic analyses were performed. RESULTS At day 4, wound bed keratinization amounted to 12.4 ± 7.5% (control) and 18.0 ± 10.2% (XCM). This increased up to day 8 (19.7 ± 25.5% control; 29.1 ± 8.0% XCM) and reached complete keratinization at day 15 in both groups. The quantitative analyses of the superficial compartment measured an increase in the amount of granulation tissue (32-88% control; 14-41% XCM) from day 4 to day 8. Angiogenesis was first detected at 8 days. At day 29, the amount of connective tissue in all compartments reached values similar to the native tissue at baseline. CONCLUSIONS The application of a XCM as a wound dressing on palatal wounds might be beneficial in the early stages of wound healing. Further research with a larger sample size is needed to confirm these results. CLINICAL RELEVANCEScientific rationale for the study: Collagen matrices (CM) were developed to increase the width of keratinized tissue around teeth and implants. This study presents the histologic analysis of the early healing of a xenogeneic collagen matrix (XCM) compared to a spontaneously healing experimental wound.Principal findings: At 4 and 8 days, the extent of the epithelial coverage was slightly greater for XCM sites than for control sites. Furthermore, at 4 days and at 8 days after surgery there was a lower amount of granulation tissue found at XCM sites. At 15 days, all experimental wounds presented a fully keratinized epithelium. Practical implications:The use of a xenogeneic collagen matrix as a palatal wound dressing may offer an accelerated wound healing at the early stages. 4ABSTRACT Aim: To test whether or not a collagen matrix can improve early wound healing compared to spontaneous healing based on histologic and immunohistologic analyses. Methods:In 20 volunteers, 6 mm punch biopsies were harvested at the palate. A xenogeneic collagen matrix (XCM) was sutured in one site; the other one was left untreated (control). Biopsies with a diameter of 8 mm were subsequently obtained at 4, 8, 15 and 29 days and histologic and immunohistologic analyses were performed.

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Section: Discussionmentioning

confidence: 99%

Palatal wound healing using a xenogeneic collagen matrix – histological outcomes of a randomized controlled clinical trial

Thoma

Hilbe

Bienz

et al. 2016

J Clinic Periodontology

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“…GBR technology refers to using the membrane as a physical barrier, allowing potential osteoblasts migrating and growth priority, preventing the connective tissue cells and epithelial cells invading into the defect, which created favorable space for the growth of osteoblasts, promoting regenerating and repairing of bone tissue in defects and increasing bone mass [9][10][11] . Collagen membrane has very good biocompatibility and GBR function, also could produce the optimal effects for guided bone regeneration around the dental implant [12] . The absorbable collagen membrane used in this study can be completely degraded in the host and there is no needing for removing the absorbable collagen membrane.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Bone Formation with Bio-Oss Guided by Collagen Membrane

Wang

Deng

Zhao

et al. 2013

J. Hard Tissue Biology.

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To observe the effect of bone formation with Bio-Oss guided by bioresorbable collagen membrane fixing. Four dogs were used in the study. Three 1cm 1cm areas were formed on bilateral mandibles randomly. The experiment include three groups: group A (Bio-OssR); group B (Bio-OssR + collagen membrane + titanium screws fixing); and group C (Bio-OssR + collagen membrane without fixing). The macroscopic, histological and scanning electron microscope observations were performed at 12 weeks postoperation. The percentage of newly-formed bone area was obtained by computer image analysis (Image-Pro Plus Computer Graphic Analysis System). The three groups all formed new bones. Group B: mature osteocytes and Haversian lamellar could be seen, and plenty of bone trabeculae were arranged in an orderly way. Group A: massive osteoblasts and bone trabeculae formation were found. Group C: there were many osteoblasts and bone lacuna, and osteocytes maturity was higher than that of group A. The average area percentage of new bone in group A was less than in groups B and C, and the average area percentage of new bone in group B was the highest (compared with groups A and C, P<0.05). These data suggest that the bone formation effectiveness of Bio-OssR combined with collagen membrane fixing was better than that of Bio-OssR only and collagen membrane without fixing.

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“…In the last two decades, numerous experimental and clinical studies have described and examined a large number of barrier membranes, their properties, and roles in guided bone regeneration [11][12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin

et al. 2014

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The properties of membranes for guided bone regeneration have been described by a number of authors. These involve biocompatibility, appropriate barrier features (mechanical prevention of soft tissue proliferation), tissue integration, immunologic neutrality, preservation of the space for new alveolar bone, and simplicity of application. Such membrane must hold out against the masticatory forces and tissue tension of the fl ap, and prevent the collapse of soft tissues and wound space reduction. The property of integration into the tissue guarantees wound stabilization and inhibits epithelial migration.The aim of this study was to compare and evaluate the infl uence of human resorbable demineralized membrane (RHDM) and bovine resorbable demineralized membrane (RBDM) on bone regeneration.The experiment, approved by the Ethical Committee, was performed on six dogs and conducted into three phases. Bone defects were created in all six dogs on the left side of the mandible, 8 weeks after extraction of the second, third and fourth premolar. One defect was covered with 200 μm thick RHDM, one with 200 μm thick RBDM, and the third defect was left empty (control defect). The pathohistological analysis was done two, four and six months after the surgery. In the third phase samples of bone tissue were taken and subjected to patohistological analysis.In all six dogs the defects treated with RHDM 200μm thick showed a higher level of bone regeneration in comparison with the defect treated with RBDM 200 μm thick and especially with the control defect.Our results demonstrated that the human membrane showed the least soft tissue ingrowth and promoted better bone formation at 6 months compared with a bovine one.

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Cross‐linked and non‐cross‐linked collagen barrier membranes disintegrate following surgical exposure to the oral environment: a histological study in the cat

Abstract: Both cross-linked and non-cross-linked membranes were resistant to tissue degradation and maintained continuity throughout the study. However, none of the membranes was resistant to degradation when exposed to the oral environment

Cited by 85 publications

References 42 publications

Palatal wound healing using a xenogeneic collagen matrix – histological outcomes of a randomized controlled clinical trial

Palatal wound healing using a xenogeneic collagen matrix – histological outcomes of a randomized controlled clinical trial

The Effect of Bone Formation with Bio-Oss Guided by Collagen Membrane

Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin

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