Cross-Linked Poly(trimethylene carbonate-<i>co</i>-<scp>l</scp>-lactide) as a Biodegradable, Elastomeric Scaffold for Vascular Engineering Applications

Dargaville, Bronwin; Vaquette, Cédryck; Peng, Hui; Rasoul, Firas; Chau, Yu Qian; Cooper-White, Justin J.; Campbell, Julie H.; Whittaker, Andrew K.

doi:10.1021/bm201291e

Cited by 63 publications

(59 citation statements)

References 61 publications

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“…Other types of biodegradable elastomers include poly(urethane urea) [6], poly(trimethylene carbonate) [7] and their associated co-polymers and derivatives [8]. These polymers are rapidly gaining acceptance as valuable bulk materials in a variety of biomedical applications including surgical meshes [9], controlled release matrices [10, 11], synthetic vascular grafts [12, 13], and scaffolds for peripheral nerve regeneration [14, 15]. The utility of this class of materials in biomedical applications is derived from the combination of mechanical compliance, total macroscopic biodegradation, and subsequent metabolism of non-toxic monomers.…”

Section: Introductionmentioning

confidence: 99%

Photocrosslinkable biodegradable elastomers based on cinnamate-functionalized polyesters

2013

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Synthetic biodegradable elastomers are an emerging class of materials that play a critical role in supporting innovations in bioabsorbable medical implants. This work describes the synthesis and characterization of poly (glycerol-co-sebacate)-cinnamate (PGS-CinA), a biodegradable elastomer based on hyperbranched polyesters derivatized with pendant cinnamate groups. PGS-CinA can be prepared via photodimerization in the absence of photoinitiator using monomers that are found in common foods. The resulting network exhibits a Young’s modulus of 50.5 to 152.1 kPa and a projected in vitro degradation half-life time between 90 and 140 days. PGS-CinA elastomers are intrinsically cell adherent and support rapid proliferation of fibroblasts. Spreading and proliferation of fibroblasts are loosely governed by the substrate stiffness within the range of Young’s moduli in PGS-CinA networks that were prepared. The thermo-mechanical properties, biodegradability, and intrinsic support of cell attachment and proliferation suggest that PGS-CinA networks abroadly applicable for use in next generation bioabsorable materials including temporary medical devices and scaffolds for soft tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Photocrosslinkable biodegradable elastomers based on cinnamate-functionalized polyesters

2013

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“…They degrade at different rates and are used in different biomedical applications. With uses in creating scaffolds for tissue engineering, PCL is a non-immunogenic semi-crystalline polymer with slow biodegradability and good drug permeability [16]. On the other hand, PTMC is an amorphous biopolymer with good mechanical resistance and high thermal and chemical stability.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a Delaying Biodegradable Magnesium Alloy-Based Esophageal Stent via Coating Elastic Polymer

Yuan

Cao

et al. 2016

Materials

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Esophageal stent implantation can relieve esophageal stenosis and obstructions in benign esophageal strictures, and magnesium alloy stents are a good candidate because of biodegradation and biological safety. However, biodegradable esophageal stents show a poor corrosion resistance and a quick loss of mechanical support in vivo. In this study, we chose the elastic and biodegradable mixed polymer of Poly(ε-caprolactone) (PCL) and poly(trimethylene carbonate) (PTMC) as the coated membrane on magnesium alloy stents for fabricating a fully biodegradable esophageal stent, which showed an ability to delay the degradation time and maintain mechanical performance in the long term. After 48 repeated compressions, the mechanical testing demonstrated that the PCL-PTMC-coated magnesium stents possess good flexibility and elasticity, and could provide enough support against lesion compression when used in vivo. According to the in vitro degradation evaluation, the PCL-PTMC membrane coated on magnesium was a good material combination for biodegradable stents. During the in vivo evaluation, the proliferation of the smooth muscle cells showed no signs of cell toxicity. Histological examination revealed the inflammation scores at four weeks in the magnesium-(PCL-PTMC) stent group were similar to those in the control group (p > 0.05). The α-smooth muscle actin layer in the media was thinner in the magnesium-(PCL-PTMC) stent group than in the control group (p < 0.05). Both the epithelial and smooth muscle cell layers were significantly thinner in the magnesium-(PCL-PTMC) stent group than in the control group. The stent insertion was feasible and provided reliable support for at least four weeks, without causing severe injury or collagen deposition. Thus, this stent provides a new stent for the treatment of benign esophageal stricture and a novel research path in the development of temporary stents in other cases of benign stricture.

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“…Photo‐crosslinked PTMC networks and co‐polymers have been previously studied with bone marrow mesenchymal stem cells (BMSCs) for vascular tissue engineering . However, the interaction between PTMC with other types of mesenchymal stem cells such as adipose stem cells (ASCs) has not been previously studied.…”

Section: Introductionmentioning

confidence: 99%

Proliferation and Differentiation of Adipose Stem Cells Towards Smooth Muscle Cells on Poly(trimethylene carbonate) Membranes

German

Behbahani

Miettinen³

et al. 2013

Macromolecular Symposia

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Summary Multipotent human adipose stem cells (hASCs) are an abundant and potential source of cells for vascular tissue engineering when combined with a suitable biomaterial scaffold. Poly(trimethylene carbonate) (PTMC) has been shown to be a useful biodegradable material for tissue engineered vascular grafts due to its flexibility, excellent biocompatibility and enzymatic degradation by surface erosion in vivo. The purpose of the current study was to evaluate the proliferation and differentiation of hASCs towards smooth muscle cells (SMCs) on gamma‐crosslinked and photo‐crosslinked PTMC membranes. PTMC macromers were functionalized with methacrylate end groups and crosslinked by UV initiated radical polymerization. High molecular weight linear PTMC was crosslinked by gamma irradiation. Cell viability, cell numbers and SMC differentiation of hASCs were evaluated on the differently crosslinked PTMC films at 7 and 14 days (d). On the photo‐crosslinked membranes, homogenous monolayers of hASC were detected by live/dead assay. Consistently, cells on the photo‐crosslinked membranes had significantly higher cell numbers compared to cells on the gamma‐crosslinked membranes after 14 d of culture. SMC specific genes were expressed on both membranes at 14 d. Photo‐crosslinked membranes showed higher expression of SMC specific proteins at 14 d compared to gamma‐crosslinked membranes. These results suggest that especially the photo‐crosslinked PTMC membranes are suitable for vascular tissue engineering applications when combined with hASCs.

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Cross-Linked Poly(trimethylene carbonate-co-l-lactide) as a Biodegradable, Elastomeric Scaffold for Vascular Engineering Applications

Cited by 63 publications

References 61 publications

Photocrosslinkable biodegradable elastomers based on cinnamate-functionalized polyesters

Photocrosslinkable biodegradable elastomers based on cinnamate-functionalized polyesters

Fabrication of a Delaying Biodegradable Magnesium Alloy-Based Esophageal Stent via Coating Elastic Polymer

Proliferation and Differentiation of Adipose Stem Cells Towards Smooth Muscle Cells on Poly(trimethylene carbonate) Membranes

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