Cross-Linking with Ultraviolet-A and Riboflavin Reduces Corneal Permeability

Stewart, Jay M.; Lee, On-Tat; Wong, Fergus F.; Schultz, David S.; Lamy, Ricardo

doi:10.1167/iovs.11-8155

Cited by 27 publications

(41 citation statements)

References 27 publications

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“…We also determined the apparent permeability coefficient (P app , cm/min) and steady-state flux (J SS , μg/mL), where ΔQ/Δt is the slope of the straight-line portion of the Q n-t plot and A is the effective area of permeation (0.5024 cm 2 ). 31 …”

Section: In Vitro Evaluation Of Corneal Penetrationmentioning

confidence: 99%

Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

Ban¹,

Zhang²,

Huang³

et al. 2017

IJN

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Drug delivery carriers can maintain effective therapeutic concentrations in the eye. To this end, we developed lipid nanoparticles (L/NPs) in which the surface was modified with positively charged chitosan, which engaged in hydrogen bonding with the phospholipid membrane. We evaluated in vitro corneal permeability and release characteristics, ocular irritation, and drug dynamics of modified and unmodified L/NPs in aqueous humor. The size of L/NPs was uniform and showed a narrow distribution. Corneal permeation was altered by the presence of chitosan and was dependent on particle size; the apparent permeability coefficient of dexamethasone increased by 2.7 and 1.8 times for chitosan-modified and unmodified L/NPs, respectively. In conclusion, a chitosan-modified system could be a promising method for increasing the ocular bioavailability of unmodified L/NPs by enhancing their retention time and permeation into the cornea. These findings provide a theoretical basis for the development of effective drug delivery systems in the treatment of ocular disease.

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Section: In Vitro Evaluation Of Corneal Penetrationmentioning

confidence: 99%

Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

Ban¹,

Zhang²,

Huang³

et al. 2017

IJN

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“…Corneal permeability has been shown to decrease in rabbit eyes following CXL both ex vivo as a reduction in mean permeability coefficient and in vivo as a reduction in pupillary response following instillation of pilocarpine drops [209]. A reduction in aqueous concentrations of ofloxacin and voriconazole following topical instillation was seen in CXL-treated eyes when compared with nonirradiated controls.…”

Section: Safetymentioning

confidence: 99%

Corneal Collagen Crosslinking: A Systematic Review

Sorkin

Varssano²

2014

Ophthalmologica

166

122

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Keratoconus (KCN) is an ectatic disorder with progressive corneal thinning and a clinical picture of corneal protrusion, progressive irregular astigmatism, corneal fibrosis and visual deterioration. Other ectatic corneal disorders include: post-LASIK ectasia (PLE) and pellucid marginal degeneration (PMD). Corneal crosslinking (CXL) is a procedure whereby riboflavin sensitization with ultraviolet A radiation induces stromal crosslinks. This alters corneal biomechanics, causing an increase in corneal stiffness. In recent years, CXL has been an established treatment for the arrest of KCN, PLE and PMD progression. CXL has also been shown to be effective in the treatment of corneal infections, chemical burns, bullous keratopathy and other forms of corneal edema. This is a current review of CXL - its biomechanical principles, the evolution of CXL protocols in the past, present and future, indications for treatment, treatment efficacy and safety.

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“…In an in vivo assay in rabbits, the same authors indirectly demonstrated reduced corneal permeability based on a significantly lower decrease in the pupillary diameter 30 minutes after pilocarpine administration compared with the non-CXL control group. 13 Also, Tschopp et al had investigated the impact of CXL on drug penetration in an ex vivo porcine eye model. CXL significantly reduced the corneal permeability of ofloxacin and voriconazole into the anterior chamber compared with the non-CXL control group.…”

mentioning

confidence: 99%