Cross-Metathesis of Vinyl-Substituted Organosilicon Derivatives With Olefins and Dienes in the Presence of Grubbs Catalysts

Pietraszuk, Cezary; Fischer, Helmut; Marciniec, Bogdan

doi:10.1007/978-1-4020-6091-5_16

Cited by 2 publications

(1 citation statement)

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“…Olefin metathesis is a highly valuable tool in the hands of a synthetic chemist and has been a subject of numerous studies in very divergent fields of chemistry . Most common classes of metathesis reaction include ring-opening metathesis polymerization (ROMP), ring-closing metathesis (RCM), ring-opening metathesis (ROM), acyclic diene metathesis (ADMET), and cross-metathesis (CM) . Metathesis assumes additional significance when directed toward bicyclic systems as substrates because they offer opportunities for incorporating additional structural complexity in the desired product.…”

Section: Applications Of Vince Lactammentioning

confidence: 99%

2-Azabicyclo[2.2.1]hept-5-en-3-one: Chemical Profile of a Versatile Synthetic Building Block and its Impact on the Development of Therapeutics

2012

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| Chem. Rev. 2012, 112, 4642−4686 4.4.3. Enantioselective Synthesis of Various Heterocyclic Compounds via ROM-RCM Domino Metathesis of Ring-Opened Vince Lactam Derivatives 4669 4.5. Use of Vince Lactam as a Standard in Chemical Analysis of Compounds and Optical Activity of Stereoisomers 4669 5. Conclusions 4669 Author Information 4669 Corresponding Author 4669 Notes 4669 Biographies 4670 Acknowledgments 4670 Abbreviations 4670 References 4671V). The well-known preference of the hydrolase enzymes to attack a substrate from si face rather than re face was studied in the system via molecular modeling of the two tetrahedral intermediates. These studies revealed that the complexes modeled on re face for both the isomers of the racemate were highly unfavorable. Furthermore, the unpropitious steric Scheme 12. Biocatalytic Resolution of Vince Lactam Followed by Various Chemical Transformations to Obtain the Desired Stereoisomers of Synthetic Intermediates Scheme 13. Proposed Mechanistic Pathway for the Biocatalytic Hydrolysis of Vince Lactam Chemical Reviews Review dx.

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