Cross‐modal restoration of ocular dominance plasticity in adult mice

Teichert, Manuel; Isstas, Marcel; Zhang, Yitong; Bolz, Jürgen

doi:10.1111/ejn.13944

Cited by 12 publications

(25 citation statements)

References 35 publications

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“…WD for subsequent HPLC analysis was performed as described previously (Teichert et al, 2018b;Teichert et al, 2018a) (see below). Micropunches of V1 were taken from 1 mm brain slices at −3.28 from Bregma from control (n=5) and WD mice (n=6, after 7 days) and…”

Section: High Performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

“…Intrinsic signal imaging experiments were performed in a total of 26 animals. In order to measure visually evoked activity of V1 we used Fourier based periodic intrinsic signal imaging (Kalatsky and Stryker, 2003;Isstas et al, 2017;Teichert et al, 2018a). Animals were initially anesthetized with 4% isoflurane in a mixture of 1:1 O 2 /N 2 O and placed on a heating blanket for maintaining body temperature (37.5°C).…”

Section: Mouse Preparation For Optical Imagingmentioning

confidence: 99%

“…Repeated intrinsic imaging in the same mice was performed as previously described (Kaneko et al, 2008;Teichert et al, 2018a). Briefly, after the first imaging (0 days) session the skin was re-sutured and animals were returned to their standard cages.…”

Section: Mouse Preparation For Repeated Imaging Experimentsmentioning

confidence: 99%

“…WD (n=11) and AD (n=9) for imaging experiments were always performed before the first imaging session (Figure 1) . WD was performed as described previously (He et al, 2012;Teichert et al, 2018a). Briefly, animals were deeply anesthetized with 2% isoflurane in a mixture of 1:1 O 2 /N 2 O applied through a plastic mask.…”

Section: Whisker Deprivation (Wd) and Auditory Deprivation (Ad)mentioning

confidence: 99%

“…To investigate the effects the effects of pure diazepam treatment in MD mice, animals received a daily injection of a diazepam solution (in saline, 1mg/kg, i.p., 0.12 ml, n=3). Furthermore, to block the Nmethyl-D-aspartate (NMDA)-receptor in monocularly deprived WD mice which also received diazepam, we daily injected a mixture containing diazepam (1mg/kg) and (R,S)-3-(2carbooxypiperazin-4-yl)propyl-1-phosphonic (CPP, Abcam, 12-15 mg/kg, n=3) Teichert et al, 2018a) in a volume of 0.12 ml (in saline, i.p.).…”

Section: Saline Diazepam and Cpp Injectionsmentioning

confidence: 99%

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Cross-modal restoration of juvenile-like ocular dominance plasticity after increasing GABAergic inhibition

Teichert¹,

Isstas²,

Wieske

et al. 2018

Preprint

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In juvenile and "young adult" mice monocular deprivation (MD) shifts the ocular dominance (OD) of binocular neurons in the primary visual cortex (V1) away from the deprived eye.However, OD plasticity is completely absent in mice older than 110 days, but can be reactivated by treatments which decrease GABA levels in V1. Typically, these OD shifts can be prevented by increasing GABAergic transmission with diazepam. We could recently demonstrate that both bilateral whisker and auditory deprivation (WD, AD), can also restore OD plasticity in mice older than 110 days, since MD for 7 days in WD mice caused a potentiation of V1 input through the ipsilateral (open) eye, the characteristic feature of OD plasticity of "young adult" mice. Here we examined whether WD for 7 days also decreases GABA levels. For this, we performed post mortem HPLC analysis of V1 tissue. Indeed, we found that WD significantly decreased GABA levels in V1. Surprisingly, enhancing GABAergic inhibition by diazepam did not abolish OD shifts in WD mice, as revealed by repeated intrinsic signal imaging. On the contrary, this treatment led to a depression of V1 input through the previously closed contralateral eye, the characteristic signature of OD plasticity in juvenile mice during the critical period. Interestingly, the same result was obtained after AD. Taken together, these results suggest that cross-modally restored OD plasticity does not only depend on reduction of GABA levels in V1, but also requires other, so far unknown mechanisms.

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Section: High Performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

Section: Mouse Preparation For Optical Imagingmentioning

confidence: 99%

Section: Mouse Preparation For Repeated Imaging Experimentsmentioning

confidence: 99%

Section: Whisker Deprivation (Wd) and Auditory Deprivation (Ad)mentioning

confidence: 99%

Section: Saline Diazepam and Cpp Injectionsmentioning

confidence: 99%

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Cross-modal restoration of juvenile-like ocular dominance plasticity after increasing GABAergic inhibition

Teichert¹,

Isstas²,

Wieske

et al. 2018

Preprint

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Ocular dominance plasticity: Molecular mechanisms revisited

Kasamatsu

Imamura

2020

J of Comparative Neurology

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Ocular dominance plasticity (ODP) is a type of cortical plasticity operating in visual cortex of mammals that are endowed with binocular vision based on the competition-driven disparity. Earlier, a molecular mechanism was proposed that catecholamines play an important role in the maintenance of ODP in kittens. Having survived the initial test, the hypothesis was further advanced to identify noradrenaline (NA) as a key factor that regulates ODP in the immature cortex. Later, the ODPpromoting effect of NA is extended to the adult with age-related limitations. Following the enhanced NA availability, the chain events downstream lead to the β-adrenoreceptor-induced cAMP accumulation, which in turn activates the protein kinase A. Eventually, the protein kinase translocates to the cell nucleus to activate cAMP responsive element binding protein (CREB). CREB is a cellular transcription factor that controls the transcription of various genes, underpinning neuronal plasticity and long-term memory. In the advent of molecular genetics in that various types of new tools have become available with relative ease, ODP research has lightly adopted in the rodent model the original concepts and methodologies. Here, after briefly tracing the strategic maturation of our quest, the review moves to the later development of the field, with the emphasis placed around the following issues: (a) Are we testing ODP per se? (b) What does monocular deprivation deprive of the immature cortex? (c) The critical importance of binocular competition, (d) What is the adult plasticity? (e) Excitation-Inhibition balance in local circuits, and (f) Species differences in the animal models.

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fNIRS Changes in the Middle Temporal and Occipital Cortices After a Cochlear Implant

Huang,

Sun

et al. 2024

The Laryngoscope

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ObjectivesThe relationship between the middle temporal (MTG) and occipital cortices in post‐lingually deaf (PLD) individuals is unclear. This study aimed to investigate changes in the MTG and occipital cortices excitability and their effects on the occipital cortex in individuals with PLD after receiving a cochlear implant (CI).MethodsTwenty‐six individuals with severe‐to‐profound binaural sensorineural PLD were assessed clinically. Nine individuals had received a unilateral cochlear implant over 6 months, while 17 had not. Brodmann area 19 (BA19, extra‐striate occipital cortex) and MTG (auditory‐related area of cortex) were selected as regions of interest. The excitability of the ROI was observed and compared in the surgery and no‐surgery groups by functional near‐infrared spectroscopy (fNIRS) in the resting state, and correlations between connectivity of the MTG and occipital cortex, and as well as the duration of time that had elapsed following CI surgery, were investigated.ResultsfNIRS revealed enhanced global cortical connectivity in the BA19 and MTG on the operative side (p < 0.05) and the connectivity between BA19 and the MTG also increased (p < 0.05). The connectivity between the MTG and BA19 was positively correlated with the duration of cochlear implantation, as was the case for BA18.ConclusionThere was evidence for remodeling of the cerebral cortex: increased excitability was observed in the MTG and BA19, and their connectivity was enhanced, indicating a synergistic effect. Moreover, the MTG may further stimulate the visual cortex by strengthening their connectivity after CI.Level of Evidence3 Laryngoscope, 2024

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Cross‐modal restoration of ocular dominance plasticity in adult mice

Cited by 12 publications

References 35 publications

Cross-modal restoration of juvenile-like ocular dominance plasticity after increasing GABAergic inhibition

Cross-modal restoration of juvenile-like ocular dominance plasticity after increasing GABAergic inhibition

Ocular dominance plasticity: Molecular mechanisms revisited

fNIRS Changes in the Middle Temporal and Occipital Cortices After a Cochlear Implant

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