Cross-over clinical trial for evaluating the safety of camel's milk intake in patients who are allergic to cow's milk protein

Navarrete-Rodríguez, Elsy Maureen; Ríos-Villalobos, L.A.; Alcocer-Arreguín, C.R.; Del-Río-Navarro, Blanca E.; Río-Chivardí, Jaime Mariano del; Saucedo-Ramírez, Omar Josué; Sienra-Monge, Juan-Jose; Frías, Rodrigo Vázquez

doi:10.1016/j.aller.2017.06.005

Cited by 34 publications

(16 citation statements)

References 17 publications

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“…The present study demonstrates that camel milk may be a suitable alternative to hypoallergenic infant formulas for CMA infant, as the low cross-reactivity should confer the camel milk low risk of inducing reactions. This is consistent with human studies showing that the introduction of camel milk to children with confirmed CMA, who did not respond to the conventional management, had a positive, rapid and long-lasting effect on their health [20,38]. Other studies have shown that neither camel milk caseins nor whey proteins could inhibit or bind to sera antibodies from patients with confirmed CMA [8,39].…”

Section: Discussionsupporting

confidence: 85%

“…Rastani et al [13] showed that CMA patients did not recognise camel milk by immunoblotting and concluded that camel milk is a promising alternative to cow’s milk for infant formula manufacture. Further, based on double-blind, placebo-controlled food challenges, Navarre-Rodriguez et al [20] concluded that camel milk is a safe and tolerable alternative for CMA patients above the age of one year. Camel milk is already commercially available in the Middle East, Australia, United Kingdom and the Netherlands [21,22,23,24].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Allergenicity and Immunogenicity of Camel and Cow’s Milk—A Study in Brown Norway Rats

et al. 2018

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Background: When breastfeeding is impossible or insufficient, the use of cow’s milk-based hypoallergenic infant formulas is an option for infants suffering from or at risk of developing cow’s milk allergy. As the Camelidae family has a large evolutionary distance to the Bovidae family and as camel milk differs from cow’s milk protein composition, there is a growing interest in investigating the suitability of camel milk as an alternative to cow’s milk-based hypoallergenic infant formulas. Methods: The aim of the study was to compare the allergenicity and immunogenicity of camel and cow’s milk as well as investigating their cross-reactivity using a Brown Norway rat model. Rats were immunised intraperitoneally with one of four products: camel milk, cow’s milk, cow’s milk casein or cow’s milk whey fraction. Immunogenicity, sensitising capacity, antibody avidity and cross-reactivity were evaluated by means of different ELISAs. The eliciting capacity was evaluated by an ear swelling test. Results: Camel and cow’s milk showed similarity in their inherent immunogenicity, sensitising and eliciting capacity. Results show that there was a lower cross-reactivity between caseins than between whey proteins from camel and cow’s milk. Conclusions: The study showed that camel and cow’s milk have a low cross-reactivity, indicating a low protein similarity. Results demonstrate that camel milk could be a promising alternative to cow’s milk-based hypoallergenic infant formulas.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Comparison of the Allergenicity and Immunogenicity of Camel and Cow’s Milk—A Study in Brown Norway Rats

et al. 2018

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“…However, the DRACMA guidelines of the World Allergy Organisation from 2010 recommend milk of other mammalians for individual patients when diagnostic indicates that they are tolerated [11]. Moreover, recent research has found camel's milk to be safe and well tolerated in patients with CMA over one year of age [30]. Both may explain the difference in opinion.…”

Section: Discussionmentioning

confidence: 99%

Development of a practice guideline for dietary counselling of children with IgE-mediated food allergy

Eisenblaetter¹,

Bürklin²,

Gschwend³

et al. 2020

Allergo J

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The incidence of food allergy is increasing globally and whilst there is consensus that dietitians should be involved in its management, the roles that dietitians should fulfil differ between different guidelines and the description of tasks remains unclear. Currently, no Swiss guideline exists to assist dietitians in counselling children with food allergies. There is a need for recommendations that will guide dietitians through the counselling process. The aim of this project was to create a practice guideline for dietary counselling of children with food allergy. MethodsPractice guidelines were developed following the Academy of Nutrition and Dietetics stepwise approach. The process consisted of six steps: 1. Determine the scope of the guideline. 2. Conduct a systematic review. 3. Draft the guideline recommendations using the Nutrition Care Process as a framework. 4. Finalise the guideline during a face-to face meeting. 5. Conduct internal and external review and revise accordingly. 6. Publish guideline. ResultsThe process resulted in 25 recommendations for dietary counselling. Most recommendations are based on expert opinion only, due to the lack of studies in this field and showed similar levels of consensus between the expert group and external review by allergists. However, there were nine recommendations where the consensus differed. ConclusionThis guideline provides a comprehensive guide to dietary counselling for food allergy by dietitians in Switzerland.It will inform best practice and improve patient-centred care and encourage a consistent approach, but it will need to be reviewed and updated as more robust evidence is produced.

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“…2018; Navarrete‐Rodríguez et al . 2018). Milk has antimicrobial activities against Gram‐positive and Gram‐negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the antibacterial properties of milk from different domestic animals

Ebrahimi

Moosavy

Khatibi

et al. 2021

Int J of Dairy Tech

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This study aimed to compare the antimicrobial properties of milk from donkey, horse, goat, sheep, cow and camel. The antibacterial properties of samples were analysed against foodborne pathogenic bacteria held at 5, 10 and 20°C during 96 h of storage. The highest antimicrobial activity was obtained with donkey and horse milk at 20°C after 96 h. This study has highlighted the variations in the antibacterial properties of the milk from various animal species. The extent of antibacterial activity of milk was shown to depend upon the animal species, the storage temperature and the bacterial strain studied.

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Cross-over clinical trial for evaluating the safety of camel's milk intake in patients who are allergic to cow's milk protein

Abstract: Camel's milk is safe and tolerable in patients above one year of age with CMPA and can be considered as a good alternative given the benefit of its taste compared to other formulas.

Cited by 34 publications

References 17 publications

Comparison of the Allergenicity and Immunogenicity of Camel and Cow’s Milk—A Study in Brown Norway Rats

Comparison of the Allergenicity and Immunogenicity of Camel and Cow’s Milk—A Study in Brown Norway Rats

Development of a practice guideline for dietary counselling of children with IgE-mediated food allergy

A comparative study of the antibacterial properties of milk from different domestic animals

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