Cross‐phyletic bioactivity of arthropod neurohormones and molluscan ganglion extracts: Evidence of an extended peptide family

Greenberg, Michael J.; Rao, K. Ranga; Lehman, Herman K.; Price, David A.; Doble, K. E.

doi:10.1002/jez.1402330302

Cited by 19 publications

(3 citation statements)

References 16 publications

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“…The adipokinetic hormones are known to increase lipid mobilization in insect muscle during flight (Stone, Mordue, Batley & Morris, 1976), enhance hyperglycaemic activity and effect cardioacceleration in insects (Baumann & Gersch, 1982;Scarborough et al 1984) and increase myoactivity in insect skeletal muscle (O'Shea, Witten & Schaffer, 1984). An RPCH/AKH-like peptide with cardioexcitatory activity has also been isolated from the clam Mercenaria mercenaria (Greenberg et al 1985).…”

Section: Introductionmentioning

confidence: 99%

A Neuronal Role for A Crustacean Red Pigment Concentrating Hormone-Like Peptide: Neuromodulation of the Pyloric Rhythm in the Crab, Cancer Borealis

Nusbaum

Marder

1988

Journal of Experimental Biology

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The distribution of red pigment concentrating hormone (RPCH)-like immunoreactivity (RPLI) in the stomatogastric nervous system of the crab, Cancer borealis, was studied using whole-mount immunocytochemistry. RPLI was seen in neuropilar processes in the stomatogastric ganglion (STG), and in somata in the oesophageal ganglion and commissural ganglia. Staining was blocked by preincubating the antiserum with RPCH, as well as with a number of adipokinetic hormones (AKHs) and related peptides. Synthetic RPCH had strong actions on the pyloric rhythm of the isolated STG. Bath applications of RPCH (10−9-10−6moll−1) increased the cycle frequency in preparations displaying slow pyloric rhythms, and initiated rhythmic pyloric activity in silent preparations. In the presence of tetrodotoxin (TTX), RPCH evoked rhythmic non-impulse-mediated alternations in membrane potential in the lateral pyloric and pyloric dilator motor neurones. The effects of RPCH were compared to those of a series of AKHs which resemble RPCH structurally. The immunocytochemical and physiological data together suggest that RPCH or a similar molecule is a neurally released modulator of the STG.

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Section: Introductionmentioning

confidence: 99%

A Neuronal Role for A Crustacean Red Pigment Concentrating Hormone-Like Peptide: Neuromodulation of the Pyloric Rhythm in the Crab, Cancer Borealis

Nusbaum

Marder

1988

Journal of Experimental Biology

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“…Also, FMRFamide was found to stimulate release of red, but not black, pigment-concentrating hormone from isolated eyestalk tissues of Uca pugilator (Butler and Fingerman, 1985). Greenberg et al (1985) reported that FMRFamide, when injected into eyestalkless Uca pugilator, had no effect on the red pigment of this crab.…”

Section: Introductionmentioning

confidence: 92%

Distal Retinal Pigment of the Fiddler Crab, Uca pugilator: Release of the Dark‐Adapting Hormone by Methionine Enkephalin and FMRFamide

Kulkarni

Fingerman

1987

Pigment Cell Research

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The neuropeptides methionine enkephalin and FMRFamide, when injected into intact fiddler crabs, Uca pugilator, produce dark adaptation of the distal retinal pigment. Furthermore, both neuropeptides stimulate release of distal retinal pigment dark-adapting hormone activity from the isolated eyestalk neuroendocrine complex. It is hypothesized that both neuropeptides, when injected into intact fiddler crabs, act only indirectly on the distal retinal pigment, by stimulating release of this dark-adapting hormone.

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“…The AKH/RPCH and PDH/PDF peptides are clearly members of peptide families common to crustaceans and insects, serving different functions in each group. Substances related to these peptide families may also occur in mollusks (Greenberg et al, 1985;Elekes and Nässel, 1999), and PDH-ir cells have also been found in the pituitary of dogfish (Vallarino et al, 1991). In addition to the available probes (e.g., antibodies to characterized peptides), knowledge of the receptors for AKH/RPCH and PDH/PDF peptides would facilitate further studies on the distribution, evolution, and functions of these molecules.…”

Section: Perspectivesmentioning

confidence: 99%

Crustacean Pigmentary-Effector Hormones: Chemistry and Functions of RPCH, PDH, and Related Peptides1

Rao

2001

American Zoologist

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SYNOPSIS. Integumental color changes and eye pigment movements in crustaceans are regulated by pigmentary-effector hormones. The identified hormones include: an octapeptide RPCH (red pigment-concentrating hormone) and several forms of octadecapeptide PDH (pigment-dispersing hormone: ␣-PDH, ␤-PDH). RPCH-related peptides (AKHs, adipokinetic hormones) and PDH-related peptides (PDFs, pigment-dispersing factors) occur in insects, and are recognized as members of AKH/RPCH and PDH/PDF peptide families. The domain for mature peptide is located between the signal peptide and precursor-related peptide in AKH/ RPCH precursors, and at the C-terminal end in the PDH/PDF precursors. The precursor-related (associated) peptides in RPCH and PDH precursors in Crustacea show little or no similarity to corresponding domains of AKH and PDF precursors in insects. Although the functions of precursor-related peptides are unknown, the mature peptides are shown to serve diverse functions. RPCH's actions in crustaceans include: pigment concentration in one or more types of chromatophores, dark-adaptational screening pigment movement in distal eye pigment cells, increase of retinal sensitivity, and neuromodulation. The related AKHs largely influence metabolism in insects, although they serve additional functions. PDHs trigger pigment dispersion in chromatophores and induce light-adaptational screening pigment movements in extraretinular eye pigment cells. The related PDFs appear to serve as a transmitter of circadian signals in the regulation of biological rhythms in insects. Evolutionary relationships among the PDH/PDF peptides and directions for future research are discussed.

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Cross‐phyletic bioactivity of arthropod neurohormones and molluscan ganglion extracts: Evidence of an extended peptide family

Cited by 19 publications

References 16 publications

A Neuronal Role for A Crustacean Red Pigment Concentrating Hormone-Like Peptide: Neuromodulation of the Pyloric Rhythm in the Crab, Cancer Borealis

A Neuronal Role for A Crustacean Red Pigment Concentrating Hormone-Like Peptide: Neuromodulation of the Pyloric Rhythm in the Crab, Cancer Borealis

Distal Retinal Pigment of the Fiddler Crab, Uca pugilator: Release of the Dark‐Adapting Hormone by Methionine Enkephalin and FMRFamide

Crustacean Pigmentary-Effector Hormones: Chemistry and Functions of RPCH, PDH, and Related Peptides1

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