Cross‐reactions in topical corticosteroid contact dermatitis

Airborne allergic contact dermatitis due to budesonide from professional exposure

“…It is reported that cross‐reactions between budesonide and other steroids occur in 90% of cases (8). Budesonide cross‐reacts with other steroids of the B and D groups of the Coopman classification and, sometimes, with steroids of the A group (1). The cross‐reaction between budesonide and molecules of the B group, and even of the A and D groups, has been explained by its molecular structure, which has similarities to other molecules.…”

“…Budesonide is a non‐halogenated, synthetic, moderately potent, topical corticosteroid; it is a group B corticosteroid in the Coopman classification (1); it is a frequent sensitizer (2).…”

Delayed Generalized Allergic Reactions to Corticosteroids

“…Most patients develop contact allergy to one or several members from corticosteroid group A (hydrocortisone type), B (triamcinolone acetonide type), C (betamethasone type) or D (hydrocortisone-17-butyrate type) [8, 9]. Cross-reactivity may be present within these groups which is supported by the similarity of the electronic shapes of the respective molecules [10], and positive patch test reactions to corticosteroids to which the patient has never been exposed [11, 12].…”

Patch testing for allergic contact dermatitis in the allergist office

“…Coopman et al [22,23] reported a seven-fold increase in frequency of positive PT to structurally related corticosteroids. Therefore, selecting a preparation of corticosteroid that belongs to another structural class might help in the management of corticosteroid allergy (Table 4).…”