Cross-reactive antibodies induced by a monovalent influenza B virus vaccine

Levandowski, Roland A.; Groß, Peter; Weksler, M E; Staton, Eldridge; Williams, Michael S.; Bonelli, J

doi:10.1128/jcm.29.7.1530-1532.1991

Cited by 40 publications

(23 citation statements)

References 8 publications

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“…Ferrets infected with an IBV from one lineage has antibodies with HAI activity against both the infecting virus, but also strains from the opposite lineage, as well as the pre-split, B/ Lee/40 IBV. [16][17][18][19][20] Therefore, younger subjects born decades after the lineage split in 1987 may have cross-reactive antibodies to these older IBV strains. This phenomenon was observed in this study during the 2014-2015 season.…”

Section: Discussionmentioning

confidence: 99%

“…However, immunological priming is often needed for this cross-reactive binding. [19][20][21] Previous exposures to IBV via infection or vaccination is most effective in the elicitation of cross-protective antibodies. This is especially the case with the Victoria lineage where studies have shown that children without detectable antibodies against Victoria-lineage strains prior to vaccination failed to exhibit a rise in these antibodies following vaccination with TIV vaccines containing only a Yamagata strain.…”

Section: Discussionmentioning

confidence: 99%

“…This is especially the case with the Victoria lineage where studies have shown that children without detectable antibodies against Victoria-lineage strains prior to vaccination failed to exhibit a rise in these antibodies following vaccination with TIV vaccines containing only a Yamagata strain. 19,20 Annual, repeated vaccination may have negative effects on the vaccine-elicited immune responses by accelerating antibody re-focusing towards prior or historical epitopes instead of newly evolved epitopes. 22 This phenomenon may select for cross-reactive, non-neutralizing antibodies, instead of crossreactive, neutralizing antibodies.…”

Section: Discussionmentioning

confidence: 99%

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Impact of age and pre-existing immunity on the induction of human antibody responses against influenza B viruses

Carlock

Ingram

Clutter

et al. 2019

Human Vaccines & Immunotherapeutics

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Pre-existing immunity to influenza is dependent on a number of factors and can vary greatly within and across influenza subtypes. In this study, volunteers (aged 18–85 years) were vaccinated with split, inactivated FluzoneTM in four consecutive influenza seasons from 2013 to 2016. The impact of repeat vaccination on breadth and durability of functional antibodies was assessed for total IgG and IgA anti-hemagglutinin (HA) binding antibodies and hemagglutination-inhibition (HAI) activity against both influenza B lineages. Many subjects were able to maintain high seroprotective titers to the vaccine strains in subsequent years, which resulted in low vaccine-induced seroconversion rates. This was especially evident in younger subjects who typically had higher titers and maintained these titers into the following season. In contrast, the HAI titers in elderly subjects were generally lower and more likely to decline prior to the start of the next influenza season. Immunological recall or ‘back-boosting’ to antigenically related viruses was associated with seroconversion. Overall, influenza vaccination in both younger and older people elicited broadly reactive immune responses within a lineage, as well as cross-reactive immune responses between lineages. This study exemplified the impact that age and influenza exposure history have on determining an individual’s ability to respond to future influenza infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impact of age and pre-existing immunity on the induction of human antibody responses against influenza B viruses

Carlock

Ingram

Clutter

et al. 2019

Human Vaccines & Immunotherapeutics

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“…Similarly to FluA, the vast majority of antibody responses against Although the two lineages are considered antigenically distinct, HA-directed antibody cross-reactivity between the two lineages has been observed in various contexts [111][112][113][114][115] potentially due to original antigenic sin [116].…”

Section: Antibody Responsesmentioning

confidence: 99%

Knowns and Unknowns of Influenza B Viruses

et al. 2015

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Influenza B viruses (IBVs) circulate annually along with influenza A (IAV) strains during seasonal epidemics. IBV can dominate influenza seasons and cause severe disease, particularly in children and adolescents. Research has revealed interesting aspects of IBV and highlighted the importance of these viruses in clinical settings. Yet, many important questions remain unanswered. In this review, the clinical relevance of IBV is emphasized, unique features in epidemiology, host range and virology are highlighted and gaps in knowledge pinpointed. Multiple aspects of IBV epidemiology, evolution, virology and immunology are discussed. Future research into IBV is needed to understand how we can prevent severe disease in high-risk groups, especially children and elderly.

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“…En todas las cohortes se observó seroconversión heteróloga frente al linaje de gripe B no incluido en la vacuna en dicha temporada, en porcentajes que fueron desde el 4% al 11% frente al linaje B/Yamagata cuando era el B/Victoria el que estaba incluido en la vacuna, y del 9% frente al linaje B/Victoria en la cohorte vacunada con el linaje B/Yamagata. Estos valores demuestran una cierta respuesta humoral heterotípica entre ambos linajes de gripe B que ya ha sido descrita en otros trabajos científicos (122,(231)(232)(233). Pese a que esta respuesta heteróloga no parece ser muy común y existe limitada información científica sobre el tema, sí que existen trabajos donde se ha demostrado protección cruzada en vacunados con linaje B/Yamagata frente a infecciones por linajes B/Victoria, hecho que no parece suceder en el sentido opuesto (233).…”

Section: Estudio De La Respuesta Inmune Humoral a La Vacuna Trivalentunclassified

Respuesta humoral específica y heteróloga frente a virus de la gripe en vacunados

Sanz-Muñoz¹

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Siempre me habían dicho que los agradecimientos es la parte más difícil de escribir de una tesis. Sin embargo, al final comprendes que te falta papel, y que como en los resultados de un trabajo de este tipo es imposible contarlo todo y agradecer a todo el mundo que alguna vez te ha ayudado. Gracias Raúl por ser mi Director, Maestro, Mentor, y Amigo. Con tu confianza y fuerza has logrado completar mi mente científica sedienta de conocimiento, has logrado hacer de la perfección una bandera para mi e inculcarme que lo mejor es enemigo de lo bueno. Gracias a ti he aprendido que la ciencia es rigor y capacidad de síntesis, es trasmisión y pasión. Y una de las cosas más importantes, el sentimiento de honor por un trabajo bien hecho. Gracias eternamente por abrirme la puerta de este apasionante mundo. Gracias Silvia por ser mi Directora, ha sido todo un honor recibir toda la sabiduría y la ayuda que me has dado durante estos años. Gracias por toda la paciencia y las ganas de trabajo que has destilado siempre, eres incombustible. Gracias también por ser tan gran amiga, me has formado como científico pero también como persona en todo este tiempo. Ante todo recuerda una cosa…. "si no fuera por estos ratos"…. Gracias Eva, mi eterna compañera de viaje, por todo tu apoyo, cariño y espíritu. Cada línea escrita en esta tesis es por y para ti, y jamás podría haber sido escrita sin tu ayuda. Gracias por creer en mí y dar todo lo que está en tu mano y un poco más para cumplir un solo sueño, volar. Te prometo y firmo aquí que viviré por siempre. Gracias Sonia por tu gran apoyo en que esto siga adelante. Me has dado ideas geniales y has apoyado otras muchas mías que aunque sonaran inverosímiles hemos logrado sacar adelante. Gracias por formar parte de nuestro día a día.

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Cross-reactive antibodies induced by a monovalent influenza B virus vaccine

Cited by 40 publications

References 8 publications

Impact of age and pre-existing immunity on the induction of human antibody responses against influenza B viruses

Impact of age and pre-existing immunity on the induction of human antibody responses against influenza B viruses

Knowns and Unknowns of Influenza B Viruses

Respuesta humoral específica y heteróloga frente a virus de la gripe en vacunados

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