Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November 2010

Skowronski, Danuta M.; Serres, Gaston De; Janjua, Naveed Z.; Gardy, Jennifer L.; Gîlca, Vladimir; Dionne, Marc; Hamelin, Marie‐Ève; Rhéaume, Chantal; Boivin, Guy

doi:10.2807/ese.17.04.20066-en

Cited by 29 publications

(27 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data are consistent with human serologic studies demonstrating that immunization with the 2010-2011 TIV has no impact on the level of cross-reactive A(H3N2)v antibodies in immunologically naive children (age, Ͻ3 years) and failed to substantially improve the level of cross-reactive antibodies in adults (17,18). Because the majority of the population lacks specific immunity against this new virus variant, an A(H3N2)v-specific vaccine is needed for optimal protection for all ages.…”

supporting

confidence: 79%

Seasonal Trivalent Inactivated Influenza Vaccine Does Not Protect against Newly Emerging Variants of Influenza A (H3N2v) Virus in Ferrets

Houser

Katz

Tumpey

2013

J Virol

View full text Add to dashboard Cite

supporting

confidence: 79%

Seasonal Trivalent Inactivated Influenza Vaccine Does Not Protect against Newly Emerging Variants of Influenza A (H3N2v) Virus in Ferrets

Houser

Katz

Tumpey

2013

J Virol

View full text Add to dashboard Cite

“…Along with the unique genotype and HA cluster, the N2 gene is derived from a human seasonal virus from 2002 instead of the N2‐1998 lineage associated with the original swine H3N2‐TRIG virus . Data show that current trivalent human influenza vaccine generates minimal HI cross‐reactivity and would likely provide no protection for this virus . Similar data evaluating swine vaccines or population immunity in swine herds against contemporary H3N2 have not been reported previously.…”

Section: Introductionsupporting

confidence: 58%

Swine influenza virus vaccine serologic cross‐reactivity to contemporary US swine H3N2 and efficacy in pigs infected with an H3N2 similar to 2011–2012 H3N2v

Kitikoon

Gauger

Anderson

et al. 2013

Influenza Resp Viruses

View full text Add to dashboard Cite

BackgroundSwine influenza A virus (IAV) reassortment with 2009 H1N1 pandemic (H1N1pdm09) virus has been documented, and new genotypes and subclusters of H3N2 have since expanded in the US swine population. An H3N2 variant (H3N2v) virus with the H1N1pdm09 matrix gene and the remaining genes of swine triple reassortant H3N2 caused outbreaks at agricultural fairs in 2011–2012.MethodsTo assess commercial swine IAV vaccines' efficacy against H3N2 viruses, including those similar to H3N2v, antisera to three vaccines were tested by hemagglutinin inhibition (HI) assay against contemporary H3N2. Vaccine 1, with high HI cross‐reactivity, was further investigated for efficacy against H3N2 virus infection in pigs with or without maternally derived antibodies (MDA). In addition, efficacy of a vaccine derived from whole inactivated virus (WIV) was compared with live attenuated influenza virus (LAIV) against H3N2.ResultsHemagglutinin inhibition cross‐reactivity demonstrated that contemporary swine H3N2 viruses have drifted from viruses in current swine IAV vaccines. The vaccine with the highest level of HI cross‐reactivity significantly protected pigs without MDA. However, the presence of MDA at vaccination blocked vaccine efficacy. The performance of WIV and LAIV was comparable in the absence of MDA.ConclusionsSwine IAV in the United States is complex and dynamic. Vaccination to minimize virus shedding can help limit transmission of virus among pigs and people. However, vaccines must be updated. A critical review of the use of WIV in sows is required in the context of the current IAV ecology and vaccine application in pigs with MDA.

show abstract

“…Given their importance in viral replication and virulence, it is probable that these segments played significant roles in the observed RD transmission. More importantly, our serologic results and of others clearly showed that our reassortant H3 isolates are antigenically divergent from recent human seasonal H3N2 strains. Therefore, previous exposure to or immunization with trivalent influenza vaccines may not elicit protective immunity against infection from these novel H3 viruses.…”

Section: Discussionsupporting

confidence: 71%

Emergence of H3N2pM‐like and novel reassortant H3N1 swine viruses possessing segments derived from the A (H1N1)pdm09 influenza virus, Korea

Pascua

Lim

Kwon

et al. 2013

Influenza Resp Viruses

View full text Add to dashboard Cite

BackgroundHuman‐to‐swine transmission of the pandemic H1N1 2009 [A(H1N1)pdm09] virus in pig populations resulted in reassortment events with endemic swine influenza viruses worldwide.ObjectiveWe investigated whether A(H1N1)pdm09‐derived reassortant viruses are present in South Korea and sought to determine the pathogenic potential of the novel swine viruses.MethodsPig lung tissues were collected from commercially slaughtered pigs. Isolated swine influenza viruses were genetically analyzed and characterized in vitro and in vivo.ResultsWe identified reassortant H3N2 (H3N2pM‐like) and H3N1 swine viruses containing A(H1N1)pdm09‐like segments in Korean pigs that are genetically closely related to strains recently detected in pigs and humans in North America. Although the H3N2pM‐like and novel H3N1 reassortants demonstrated efficient replication in mice and ferrets, all the H3N1 strains exhibited growth advantage over the representative H3N2pM‐like virus in human airway cells. Interestingly, A/swine/Korea/CY02‐07/2012(H3N1) and A/swine/Korea/CY03‐13/2012(H3N1) reassortants were more readily transmitted to respiratory‐droplet‐contact ferrets compared with the H3N2pM‐like (A/swine/Korea/CY02‐10/2012) isolate. Furthermore, serologic evaluation showed poor antigenicity to contemporary reference human seasonal H3N2 vaccine strains.ConclusionsWe report here for the first time the isolation of H3N2pM‐like viruses outside North America and of novel reassortant swine H3N1 viruses with A(H1N1)pdm09‐derived genes. Apart from further complicating the genetic diversity of influenza A viruses circulating in domestic pigs, our data also indicate that these strains could potentially pose threat to public health asserting the need for continuous virus monitoring in these ecologically important hosts.

show abstract

Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November 2010

Abstract: Binary file ES_Abstracts_Final_ECDC.txt matches

Cited by 29 publications

References 17 publications

Seasonal Trivalent Inactivated Influenza Vaccine Does Not Protect against Newly Emerging Variants of Influenza A (H3N2v) Virus in Ferrets

Seasonal Trivalent Inactivated Influenza Vaccine Does Not Protect against Newly Emerging Variants of Influenza A (H3N2v) Virus in Ferrets

Swine influenza virus vaccine serologic cross‐reactivity to contemporary US swine H3N2 and efficacy in pigs infected with an H3N2 similar to 2011–2012 H3N2v

Emergence of H3N2pM‐like and novel reassortant H3N1 swine viruses possessing segments derived from the A (H1N1)pdm09 influenza virus, Korea

Contact Info

Product

Resources

About