2023
DOI: 10.1080/21645515.2023.2210961
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Cross-reactive humoral immunity of clade 2 Oka and MAV/06 strain-based varicella vaccines against different clades of varicella–zoster virus

Abstract: The currently used Japanese Oka and Korean MAV/06-attenuated varicella vaccine strains belong to clade 2 genotype varicella–zoster viruses (VZV). More than seven clades of VZV exist worldwide. In this study, we investigated the cross-reactivity of antibodies induced by clade 2 genotype vaccines against VZV strains belonging to clades 1, 2, 3, and 5 using a fluorescent antibody to membrane antigen (FAMA) test. Among 59 donors, 29 were vaccinated with the MAV/06 strain MG1111 (GC Biopharma, South Korea) and the … Show more

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“…Both Oka and MAV/06 strain-based varicella vaccines can induce cross-reactive humoral immunity against other clades of VZV [ 8 ]. However, no data exist on the safety and tolerability of interchanging the OKA and MAV/06 strain-based vaccines.…”
Section: Discussionmentioning
confidence: 99%
“…Both Oka and MAV/06 strain-based varicella vaccines can induce cross-reactive humoral immunity against other clades of VZV [ 8 ]. However, no data exist on the safety and tolerability of interchanging the OKA and MAV/06 strain-based vaccines.…”
Section: Discussionmentioning
confidence: 99%