Cross‐reactivity among birch pollen, vegetables and fruits as detected by IgE antibodies is due to at least three distinct cross‐reactive structures

Calkhoven, P. G.; Aalbers, M.; Koshte, V. L.; Pos, Odette; Oei, H.D.; Aalberse, R. C.

doi:10.1111/j.1398-9995.1987.tb02225.x

Cited by 159 publications

(82 citation statements)

References 17 publications

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“…However, Kivity et al have reported that when sensitization to food allergens occurs after the age of 10 y, fruits and vegetables appear to be the main causative agents (Kivity et al, 1994). Although immunological cross-reactivity of plant aeroallergens with fruits are well-documented (Calkhoven et al, 1987;Eriksson et al, 1982), the clinical relevance of this remains unclear (Bock, 1991).…”

Section: Discussionmentioning

confidence: 99%

International prevalences of reported food allergies and intolerances. Comparisons arising from the European Community Respiratory Health Survey (ECRHS) 1991–1994

et al. 2001

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Objective: The aim of this study was to report the prevalence, type and reported symptoms associated with food intolerance. Design: A cross-sectional epidemiological study involving 15 countries using standardized methodology. Participants answered a detailed interviewer-administered questionnaire and took part in blood, lung function and skin prick tests to common aeroallergens. Setting: Randomly selected adults who took part in the second phase of the European Community Respiratory Health Survey (ECRHS). Subjects: The subjects were 17 280 adults aged 20 ± 44 y. Results: Twelve percent of respondents reported food allergyaintolerance (range 4.6% in Spain to 19.1% in Australia). Atopic females who had wheezed in the past 12 months, ever had asthma or were currently taking oral asthma medications were signi®cantly more likely to report food allergyaintolerance. Participants from Scandinavia or Germany were signi®cantly more likely than those from Spain to report food allergyaintolerance. Respondents who reported breathlessness as a food-related symptom were more likely to have wheezed in the past 12 months, to have asthma, use oral asthma medications, be atopic, have bronchial hyperreactivity, be older and reside in Scandinavia. Conclusion: Self-reported food allergyaintolerance differed signi®cantly across multiple countries. The reasons for these differences were not explored in this study, but are likely to be largely due to cultural differences.

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Section: Discussionmentioning

confidence: 99%

International prevalences of reported food allergies and intolerances. Comparisons arising from the European Community Respiratory Health Survey (ECRHS) 1991–1994

et al. 2001

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“…Profilin and Bet v I allergens have been demonstrated to be responsible for cross-reactions among pollens, vegetables and fruits [35,361. Oligosaccharides contained in glycoallergens have been reported to have common structures that could contribute to cross-reactivity processes [35,371. However, certain cross-reactions have not been explained.…”

Section: Discussionmentioning

confidence: 99%

Ole e 3, An Olive‐Tree Allergen, Belongs to a Widespread Family of Pollen Proteins

Batanero

Villalba

Ledesma

et al. 1996

European Journal of Biochemistry

115

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An allergen has been isolated from a saline extract of olive tree (Olea europaea) pollen. The protein consists of a single polypeptide chain of 9.2-kDa, as determined by mass spectrometry. It contains neither tryptophan nor tyrosine residues, and displays an acidic isoelectric point. The secondary structure of the protein, estimated from the analysis of the circular-dichroism spectrum in the peptide-bond region, is composed of 52% a-helix, 10% a-strand, 29% Sturn and 9% non-regular conformation. The N-terminal end of the protein is blocked. Amino-acid-sequence data have been obtained from peptides produced by CNBr treatment of the native allergen. A partial sequence of 36 amino acids has thus been elucidated. The protein exhibits sequence similarity with pollen allergens from Brassica species and contains a Caz'-binding motif. The isolated protein displays IgE-binding activity against sera of patients allergic to olivetree pollen. It has been named Ole e 3, according to the recommendations of the IUIS Nomenclature Committee. IgG ELISA inhibition assays with polyclonal antibodies specific for Ole e 3 reveal the presence of proteins similar to Ole e 3 in the pollen from non-related plant species, which may explain allergic cross-reactivity processes.Keywords: allergen ; olive pollen ; Olea europaea ; Ole e 3 ; protein characterization.Type-I allergy is a clinical disorder that affects more than 15 % of the human population in developed countries. Olive pollinosis is one of the most important causes of type-I allergy in Mediterranean countries, where the olive tree is widely cultivated [l]. Ole e 1 has been shown to be a major allergen from olive pollen, since the IgE of more than 70% of olive-allergic patients recognize this protein [2-41. In addition to Ole e 1, other allergenic proteins have been detected in saline extracts of the olive pollen 15-71, some of which exhibit low molecular masses. Preliminary studies on these molecules were performed with pools of sera from patients hypersensitive to olive pollen. Lauzurica et al. 121 showed the existence of an IgE-reacting protein of 8 kDa upon SDS/PAGE of the pollen extract. Proteins of 7, 9, 14, 15 and 16 kDa, present in olive pollen, have been immunostained with individual sera from olive allergic patients [8]. However, isolation or molecular characterization was not performed for these allergens.Allergic cross-reactivities have been described among Oleaceae members. such as olive, ash and privet [9-131 as well as between olive-pollen and grass-pollen proteins [8]. In addition to profilin, which is an important and well defined panallergen involved in cross-reactions [ 141, other proteins contained in pollen from different species that have conserved sequences could be responsible for allergic processes in individuals not previously sensitized to a given biological source.In spite of the knowledge of a high number of allergenic structures, little is known about their B-cell and T-cell epitopes and the mechanism of induction of allergy. The protein allergens fre...

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“…involving allergy to fresh fruits / vegetables and sensitization to inhalant pollen allergens are commonly encountered in allergy clinics, sometimes extending over a range of botanically unrelated plant species (9)(10)(11). Typically, these patients experience itchy mouth, tongue (oropharyngeal pruritus), and glottic edema, commonly recognized as pollen-food allergy syndrome or oral allergy syndrome (OAS) (12); it has been shown that ~2-4% of European adults experience this syndrome.…”

Section: Allergic Subjects and Case Historymentioning

confidence: 99%

“…Well-known examples of such cross-allergenicity are: (i) birch pollen (apple, hazelnut, carrot, potato, celery, kiwi fruit, etc), (ii) mugwort pollen (celery, carrot, spices), (iii) grass pollen (melon, tomato, peanut, watermelon, orange), and (iv) ragweed pollen (melon, watermelon, banana, zucchini, cucumber). Approximately 35% of patients with such types of pollinosis show hypersensitivity to antigenically-related fruits and vegetables (9)(10)(11)(12). Profilins (12-15 kDa) are a family of highly conserved plant pan-allergens (13)(14)(15).…”

Section: Allergic Subjects and Case Historymentioning

confidence: 99%

Skin prick test analysis reveals cross-sensitization to tomato profilin and grass pollen in nasobronchialallergic patients with history of tomato food allergy

Hegde

Modesti²,

Venkatesh

2018

Eur Ann Allergy Clin Immunol

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SummaryThe association between grass pollen sensitization and food allergy to tomato is of great interest. We report here, the first such study in Indian population. We investigated 246 allergic rhinitis / asthma patients by diagnostic case history and skin prick test (SPT); grass pollen mix, tomato extract and purified tomato profilin were used for SPT. Tomato profilin was purified by affinity chromatography, and analyzed by HPLC (95% purity) and SDS-PAGE (14 kDa).We observed that 38% of the patients had sensitization to both grass pollen and tomato fruit, of which 92% were sensitized to tomato profilin. Among patients with a history of food allergy to tomato fruit, the association was more pronounced (66%). Tomato profilin appears to be an important cross-sensitizing panallergen in respiratory allergic patients in the Indian subcontinent.

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Cross‐reactivity among birch pollen, vegetables and fruits as detected by IgE antibodies is due to at least three distinct cross‐reactive structures

Cited by 159 publications

References 17 publications

International prevalences of reported food allergies and intolerances. Comparisons arising from the European Community Respiratory Health Survey (ECRHS) 1991–1994

International prevalences of reported food allergies and intolerances. Comparisons arising from the European Community Respiratory Health Survey (ECRHS) 1991–1994

Ole e 3, An Olive‐Tree Allergen, Belongs to a Widespread Family of Pollen Proteins

Skin prick test analysis reveals cross-sensitization to tomato profilin and grass pollen in nasobronchialallergic patients with history of tomato food allergy

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