Cross-Reactivity between &lt;b&gt;&lt;i&gt;Anisakis&lt;/i&gt;&lt;/b&gt; spp. and Wasp Venom Allergens

Rodríguez-Pérez, Rosa; Monsalve, Rafaél I.; Galán, Agustín; Pérez-Piñar, Teresa; Umpiérrez, Ana; Lluch-Bernal, M; Polo, Francisco Javier Ferrer; Caballero, María Luisa

doi:10.1159/000358060

Cited by 17 publications

(8 citation statements)

References 19 publications

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“…Unfortunately, this has no effect on the nematode but may contribute to host tissue damage [ 114 ]. Curiously, Anisakis toxins are also endowed with a potential cross-reactivity with wasp venom allergens [ 115 ]. Hypersensitivity reactions due to Anisakis exposure (including life-threatening anaphylaxis [ 116 ]) are thus not infrequent and may coexist with the complications of acute infection.…”

Section: Eosinophils In Infectious Diseasesmentioning

confidence: 99%

Eosinophils from Physiology to Disease: A Comprehensive Review

Ramirez

Yacoub

Ripa

et al. 2018

BioMed Research International

224

198

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Despite being the second least represented granulocyte subpopulation in the circulating blood, eosinophils are receiving a growing interest from the scientific community, due to their complex pathophysiological role in a broad range of local and systemic inflammatory diseases as well as in cancer and thrombosis. Eosinophils are crucial for the control of parasitic infections, but increasing evidence suggests that they are also involved in vital defensive tasks against bacterial and viral pathogens including HIV. On the other side of the coin, eosinophil potential to provide a strong defensive response against invading microbes through the release of a large array of compounds can prove toxic to the host tissues and dysregulate haemostasis. Increasing knowledge of eosinophil biological behaviour is leading to major changes in established paradigms for the classification and diagnosis of several allergic and autoimmune diseases and has paved the way to a “golden age” of eosinophil-targeted agents. In this review, we provide a comprehensive update on the pathophysiological role of eosinophils in host defence, inflammation, and cancer and discuss potential clinical implications in light of recent therapeutic advances.

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Section: Eosinophils In Infectious Diseasesmentioning

confidence: 99%

Eosinophils from Physiology to Disease: A Comprehensive Review

Ramirez

Yacoub

Ripa

et al. 2018

BioMed Research International

224

198

View full text Add to dashboard Cite

show abstract

“…Although the sample was drawn from healthy women, ELISA revealed a sensitization rate of approximately 25%. Although total antigens are used more often and are easier to obtain, they may cross-react with some antigens ( Lorenzo et al, 2001 , Rodriguez-Perez et al, 2014 , Weiler, 2007 ). Furthermore, during antenatal care in Brazil, women usually receive anthelmintic treatment.…”

Section: Discussionmentioning

confidence: 99%

Principal component analysis of factors for sensitization to Anisakis spp. in postpartum women

Figueiredo¹,

Vericimo²,

Clemente³

et al. 2016

Parasite Epidemiology and Control

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IntroductionImmunoreactivity to Anisakis spp. is believed to be associated with frequency of fish intake. The objective of this study was to evaluate, using principal component analysis, the main factors potentially involved in reactivity to these nematodes in postpartum women.MethodsRetrospective study conducted on a database of 309 postpartum women. All completed a structured questionnaire and had blood samples collected for ELISA analysis of specific immunoglobulins against total Anisakis spp. antigens and assessment of reactivity. Parametric and nonparametric tests were used to assess factors for sensitization in the reactive and nonreactive groups, and a principal component analysis was performed. A Pearson correlation matrix with varimax rotation was used to assess the variables of interest (place of residence, age, number of prenatal visits, type of birth facility, fish intake and frequency, raw fish intake, fish handling, history of allergies).ResultsAfter exclusions, samples from 203 women were assessed. Of these, 52 (25.6%) were reactive for anti-Anisakis IgG. Most women claimed not to handle fish (n = 121) and eat fish only sporadically (n = 71). Significant differences in age were seen between the reactive and nonreactive groups (p = 0.001). The first two components explained 32.55% and 38.94% of variances in the nonreactive and reactive groups respectively. The adjusted matrix assigned greater probabilistic weight to weekly intake frequency (0.804), followed by raw fish intake (0.759), with differences in relation to the nonreactive group.ConclusionCorrelation matrices revealed a direct relationship between seroreactivity to Anisakis spp. and frequency of fish intake in a sample of postpartum women.

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“…[116][117][118][119][120][121][122][123][124][125][126][127][128] We have demonstrated that helminth infection can be associated with increased IgE responses to many different allergens, especially those structurally related to parasite antigens. 116 Individuals infected with filarial parasites were shown to have higher levels of IgE against HDM and cockroach extracts (that have several major allergens with homologues in filarial parasites) but not against timothy grass extract, an allergen extract with just a few minor allergen homologues in helminths.…”

Section: -89mentioning

confidence: 99%

Human Helminths and Allergic Disease: The Hygiene Hypothesis and Beyond

Santiago

Nutman

2016

The American Society of Tropical Medicine and Hygiene

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Abstract. There is much debate about the interaction between helminths and allergic disease. The "Hygiene Hypothesis," a very popular concept among scientists and the lay public, states that infections, especially during childhood, can protect against allergic diseases. Indeed, helminth infections are known to induce regulatory responses in the host that can help the control of inflammation (including allergic inflammation). However, these infections also induce type-2-associated immune responses including helminth-specific IgE that can cross-react against environmental allergens and mediate IgE-driven effector responses. Thus, it is the delicate balance between the parasites' anti-and pro-allergenic effects that define the helminth/allergy interface.The immune system has evolved, in large part, through its interaction with microbes and parasites, an interaction that drives specific or specialized immune responses to deal with the widely varying groups of microorganisms. For example, parasite-derived induction of interleukin (IL)-4, IL-5, and IL-13 coordinate the prototypical responses to metazoan helminth pathogens, 1 whereas viral-and bacterial-specific induction of Type 1 and Type 2 interferons are required for control of these types of infections.

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Cross-Reactivity between <b><i>Anisakis</i></b> spp. and Wasp Venom Allergens

Cited by 17 publications

References 19 publications

Eosinophils from Physiology to Disease: A Comprehensive Review

Eosinophils from Physiology to Disease: A Comprehensive Review

Principal component analysis of factors for sensitization to Anisakis spp. in postpartum women

Human Helminths and Allergic Disease: The Hygiene Hypothesis and Beyond

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