2011
DOI: 10.1128/cvi.05017-11
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Cross-Reactivity in the Histoplasma Antigen Enzyme Immunoassay Caused by Sporotrichosis

Abstract: Several endemic mycoses cause cross-reactions in theHistoplasmaantigen enzyme immunoassay. Herein, a positiveHistoplasmaantigen result has been recognized in a patient with sporotrichosis.

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Cited by 39 publications
(28 citation statements)
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“…The sensitivity for detection of antigenemia is similar to that for antigenuria (100% vs. 97%) in disseminated infection . The specificity of antigen detection is 99%, however, cross‐reactive antigen is detected in 90% of patients with blastomycosis, and has also been reported in the setting of other endemic fungal infections such as sporotrichosis . The degree of antigenuria correlates with the severity of disseminated infection: concentrations of ≥19 ng/mL occurs in 73% of severe cases, 39% of moderately severe cases and 17% of mild cases .…”
Section: Histoplasmosismentioning
confidence: 74%
“…The sensitivity for detection of antigenemia is similar to that for antigenuria (100% vs. 97%) in disseminated infection . The specificity of antigen detection is 99%, however, cross‐reactive antigen is detected in 90% of patients with blastomycosis, and has also been reported in the setting of other endemic fungal infections such as sporotrichosis . The degree of antigenuria correlates with the severity of disseminated infection: concentrations of ≥19 ng/mL occurs in 73% of severe cases, 39% of moderately severe cases and 17% of mild cases .…”
Section: Histoplasmosismentioning
confidence: 74%
“…Results from one study suggest that this urine antigen test is highly sensitive and specific for histoplasmosis in cats . However, that study did not include cats with fungal infections other than histoplasmosis, and other fungal species could cause false‐positive results in humans . As such, we cannot confirm the fungal species in the majority of the cats from this series.…”
Section: Discussionmentioning
confidence: 86%
“…The Histoplasma antigen assay is susceptible to cross-reactivity with other organisms and, thus, is not sufficient to diagnose histoplasmosis in the absence of additional supporting diagnostics. This has been described with Blastomyces, Coccidioides, Paracoccidioides, Sporothrix, Aspergillus, and Talaromyces marneffei [27,29,[32][33][34]. Similarly, a false-positive Aspergillus antigen test may be seen in patients with histoplasmosis, especially those with high titers.…”
Section: Diagnosismentioning
confidence: 90%