Cross-Reactivity of Selected Benzofurans with Commercial Amphetamine and Ecstasy Immunoassays in Urine

Gomila, Isabel; Moranta, Concepción; Quesada, Loreto; Pastor, Yolanda; Dastis, Macarena; Torrents, Albert; Elorza, Miguel Ángel; Busardò, Francesco Paolo; Barceló, Bernardino

doi:10.4155/bio-2017-0191

Cited by 10 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Benzofurans have been successfully detected in both biological and non‐biological matrices, with either simple or elaborate analytical methodologies (Table ). A number of benzofuran compounds displayed cross‐reactivity in immunoassay urine screenings for MDMA and other amphetamines (Gomila et al, ; McIntyre et al, ). Quantitative and qualitative analysis of urine and blood or serum using either liquid or gas chromatography techniques coupled with mass spectrometry (LC‐MS and GC‐MS, respectively) were performed in the few clinical case reports publicly available.…”

Section: Chemistry and Chemical Analysismentioning

confidence: 99%

Benzo fury: A new trend in the drug misuse scene

Bravo

Carmo

Carvalho

et al. 2019

J of Applied Toxicology

View full text Add to dashboard Cite

Benzofurans, also known by users as benzo fury or benzofury, are synthetic phenethylamines and constitute the third most prominent group of new psychoactive substances (NPS). As the use of these substances has been spread as an alternative to the classic illicit psychostimulants, such as amphetamines, their legal status was reviewed, resulting in an utter prohibition of these NPS in many countries worldwide.Herein, the prevalence of abuse, chemistry, biological effects, metabolism, and the potential harms and risky behaviors associated with the abuse of benzofurans are reviewed. The congeners of this group are mainly consumed recreationally at electronic dance music parties, in polydrug abuse settings. Benzofurans preferentially act by disturbing the functioning of serotonergic circuits, which induces their entactogenic and stimulant effects and is the reason behind the considerable number of recent benzo fury-related deaths. The slight interaction of these drugs with the dopaminergic system justifies the rewarding effects of these drugs. To date, published evidence on the mechanisms of toxicity of benzo fury is very limited but a body of research is now beginning to emerge revealing an alarming public health threat regarding the abuse of these NPS.

show abstract

Section: Chemistry and Chemical Analysismentioning

confidence: 99%