Cross-Recognition of<i>N</i>-Formylmethionine Peptides Is a General Characteristic of H2-M3-Restricted CD8<sup>+</sup>T Cells

Ploß, Alexander; Tran, An Hue Vy; Menet, Ewa; Leiner, Ingrid; Pamer, Eric G.

doi:10.1128/iai.73.7.4423-4426.2005

Cited by 6 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that some H2-M3-restricted LMspecifi c CTLs are cross-reactive with antigens derived from a variety of Gram-positive and Gram-negative bacteria (29). In addition, deletion of H2-M3-restricted epitopes from LM does not prevent the priming of H2-M3-restricted T cells with specifi city for the deleted epitope, suggesting that promiscuous antigen recognition may be a feature common to many H2-M3-restricted T cells (30)(31)(32). The promiscuous recognition and cross-reactivity to common environmental bacteria may lead to the priming and expansion of LM-reactive H2-M3-restricted T cells in "naive" animals, resulting in increased precursor frequency as well as a "primed" state.…”

Section: Discussionmentioning

confidence: 99%

Impaired response to Listeria in H2-M3–deficient mice reveals a nonredundant role of MHC class Ib–specific T cells in host defense

Chun

Choi

et al. 2006

The Journal of Experimental Medicine

View full text Add to dashboard Cite

The major histocompatibility complex (MHC) class Ib molecule H2-M3 primes the rapid expansion of CD8+ T cells by presenting N-formylated bacterial peptides. However, the significance of H2-M3–restricted T cells in host defense against bacteria is unclear. We generated H2-M3–deficient mice to investigate the role of H2-M3 in immunity against Listeria monocytogenes (LM), a model intracellular bacterial pathogen. H2-M3–deficient mice are impaired in early bacterial clearance during primary infection, with diminished LM-specific CD8+ T cell responses and compromised innate immune functions. Although H2-M3–restricted CD8+ T cells constitute a significant proportion of the anti-listerial CD8+ T cell repertoire, the kinetics and magnitude of MHC class Ia–restricted T cell responses are not altered in H2-M3–deficient mice. The fact that MHC class Ia–restricted responses cannot compensate for the H2-M3–mediated immunity suggests a nonredundant role of H2-M3 in the protective immunity against LM. Thus, the early H2-M3–restricted response temporally bridges the gap between innate and adaptive immune responses, subsequently affecting the function of both branches of the immune system.

show abstract

Section: Discussionmentioning

confidence: 99%

Impaired response to Listeria in H2-M3–deficient mice reveals a nonredundant role of MHC class Ib–specific T cells in host defense

Chun

Choi

et al. 2006

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…Despite the limited polymorphism of H2-M3 molecules, several distinct Lm -derived peptides containing N-formyl-methionine have been shown to induce CD8 + T cell responses [ 153 , 154 , 155 ], with fMIGWII being the major immunodominant epitope during Lm infection [ 156 ]. H2-M3-restricted CD8 + T cells express promiscuous antigen receptors which enable them to broadly recognize N-formylated peptides produced by Lm [ 157 , 158 , 159 ].…”

Section: Non-classical H2-m3-restricited Cd8 T Cell Responsementioning

confidence: 99%

Listeria Monocytogenes: A Model Pathogen Continues to Refine Our Knowledge of the CD8 T Cell Response

2018

View full text Add to dashboard Cite

Listeria monocytogenes (Lm) infection induces robust CD8 T cell responses, which play a critical role in resolving Lm during primary infection and provide protective immunity to re-infections. Comprehensive studies have been conducted to delineate the CD8 T cell response after Lm infection. In this review, the generation of the CD8 T cell response to Lm infection will be discussed. The role of dendritic cell subsets in acquiring and presenting Lm antigens to CD8 T cells and the events that occur during T cell priming and activation will be addressed. CD8 T cell expansion, differentiation and contraction as well as the signals that regulate these processes during Lm infection will be explored. Finally, the formation of memory CD8 T cell subsets in the circulation and in the intestine will be analyzed. Recently, the study of CD8 T cell responses to Lm infection has begun to shift focus from the intravenous infection model to a natural oral infection model as the humanized mouse and murinized Lm have become readily available. Recent findings in the generation of CD8 T cell responses to oral infection using murinized Lm will be explored throughout the review. Finally, CD8 T cell-mediated protective immunity against Lm infection and the use of Lm as a vaccine vector for cancer immunotherapy will be highlighted. Overall, this review will provide detailed knowledge on the biology of CD8 T cell responses after Lm infection that may shed light on improving rational vaccine design.

show abstract

Predict prokaryotic proteins through detecting N-formylmethionine residues in protein sequences using support vector machine

Yang

2009

Biosystems

View full text Add to dashboard Cite

Cross-Recognition ofN-Formylmethionine Peptides Is a General Characteristic of H2-M3-Restricted CD8⁺T Cells

Cited by 6 publications

References 17 publications

Impaired response to Listeria in H2-M3–deficient mice reveals a nonredundant role of MHC class Ib–specific T cells in host defense

Impaired response to Listeria in H2-M3–deficient mice reveals a nonredundant role of MHC class Ib–specific T cells in host defense

Listeria Monocytogenes: A Model Pathogen Continues to Refine Our Knowledge of the CD8 T Cell Response

Predict prokaryotic proteins through detecting N-formylmethionine residues in protein sequences using support vector machine

Contact Info

Product

Resources

About

Cross-Recognition ofN-Formylmethionine Peptides Is a General Characteristic of H2-M3-Restricted CD8+T Cells

Cited by 6 publications

References 17 publications

Impaired response to Listeria in H2-M3–deficient mice reveals a nonredundant role of MHC class Ib–specific T cells in host defense

Impaired response to Listeria in H2-M3–deficient mice reveals a nonredundant role of MHC class Ib–specific T cells in host defense

Listeria Monocytogenes: A Model Pathogen Continues to Refine Our Knowledge of the CD8 T Cell Response

Predict prokaryotic proteins through detecting N-formylmethionine residues in protein sequences using support vector machine

Contact Info

Product

Resources

About

Cross-Recognition ofN-Formylmethionine Peptides Is a General Characteristic of H2-M3-Restricted CD8⁺T Cells