2017
DOI: 10.3390/v9030057
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Cross-Regulation between Transposable Elements and Host DNA Replication

Abstract: Transposable elements subvert host cellular functions to ensure their survival. Their interaction with the host DNA replication machinery indicates that selective pressures lead them to develop ancestral and convergent evolutionary adaptations aimed at conserved features of this fundamental process. These interactions can shape the co-evolution of the transposons and their hosts.

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Cited by 13 publications
(9 citation statements)
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“…Also for Arabidopsis , we and others have seen that RBR1 is involved in DNA repair at the site of the lesion [34,35], partially co-localizing with RAD51, a major player in HR [34]. It is known that TEs use and modify the cellular machinery of the host at several levels to promote their own survival [104,105]. Thus, RBR1 might provide a link to the recombination/repair machinery required for stable MITE transposition in the host genome.…”
Section: Discussionmentioning
confidence: 99%
“…Also for Arabidopsis , we and others have seen that RBR1 is involved in DNA repair at the site of the lesion [34,35], partially co-localizing with RAD51, a major player in HR [34]. It is known that TEs use and modify the cellular machinery of the host at several levels to promote their own survival [104,105]. Thus, RBR1 might provide a link to the recombination/repair machinery required for stable MITE transposition in the host genome.…”
Section: Discussionmentioning
confidence: 99%
“…For example, tRF production could be a consequence of low H3K9me3 levels and tRNA metabolism [65]. Of course it is ideal for transposons to replicate in highly proliferating cells: high levels of tRNAs for translation of viral proteins and RT priming, abundant replication forks, and breakdown of the nuclear membrane for genome integration all play in favor of transposition [59, 66, 67]. Transposition rates can be limited by host tRNA expression [68] and oncogenic LTR-retroviruses like RSV and MuLV are known to induce expression of their primer tRNA [69].…”
Section: Trf Biogenesis - the Who? What? When? Where? Why?mentioning
confidence: 99%
“…DNA transposons are mobilized during DNA replication, and LTR retrotransposons are preferentially inserted at sites of replication fork arrest (67). In that regard, fork arrest and slower S-phase completion caused by replication stress and checkpoint activation is likely to favor TE mobilization.…”
Section: Discussionmentioning
confidence: 99%