Cross‐sectional analysis of healthy individuals across decades: Aging signatures across multiple physiological compartments

Abstract

The study of age‐related biomarkers from different biofluids and tissues within the same individual might provide a more comprehensive understanding of age‐related changes within and between compartments as these changes are likely highly interconnected. Understanding age‐related differences by compartments may shed light on the mechanism of their reciprocal interactions, which may contribute to the phenotypic manifestations of aging. To study such possible interactions, we carried out a targeted metabolomic analysis of plasma, skeletal muscle, and urine collected from healthy participants, age 22–92 years, and identified 92, 34, and 35 age‐associated metabolites, respectively. The metabolic pathways that were identified across compartments included inflammation and cellular senescence, microbial metabolism, mitochondrial health, sphingolipid metabolism, lysosomal membrane permeabilization, vascular aging, and kidney function.

New insights into healthy ageing, inflammageing and frailty using metabolomics

“…However, there have been studies in which aspartate is also increased within frailty ( Adachi et al, 2018 ; Calvani et al, 2021 ). High levels of 3-methyl-histidine have been reported as an indicator for physical frailty, as it is involved in muscle catabolism ( Moaddel et al, 2024 ).…”

Healthy aging: Linking causal mechanisms with holistic outcomes

“…Understanding organ crosstalk is vital for developing holistic and integrative approaches to enhance healthspan and to potentially extend lifespan. Moaddel and colleagues ( 2023 ) conducted a cross‐sectional analysis of healthy individuals aged 22–92 years old to provide a comprehensive assessment of age‐related biomarkers across different biofluids and tissues within the same individuals, revealing interconnected age‐associated metabolic pathways to facilitate the discovery of mechanisms underlying phenotypic aging.…”